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Öğe Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats(Taylor & Francis Ltd, 2012) Beytur, Ali; Kose, Evren; Sarihan, Mehmet Ediz; Sapmaz, Hilal Irmak; Dogan, Zumrut; Cetin, Asli; Vardi, NigarObjective: In this study, the therapeutic and protective effects of montelukast against cisplatin (CP)-induced acute renal damage were investigated. Materials and Methods: Thirty-five female rats were divided into five groups as follows: (1) control, (2) montelukast (10 mg/kg daily for 10 days per-oral (p.o.), (3) CP (single dose 7 mg/kg intraperitoneally (i.p.)), (4) CP + montelukast (10 mg/kg daily for 10 days p.o., after 3 days of the injection of CP), (5) montelukast (10 mg/kg daily for 10 days p.o.) + CP (single dose 7 mg/kg i.p., after the last dose of montelukast). At the end of the experiment, malondialdehyde (MDA), a lipid peroxidation product, myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined in the renal tissue. Also, blood urea nitrogen (BUN) and creatinine (Cr) levels were assayed from the trunk blood samples. Results: CP treatment caused a significant elevation of MDA, MPO, BUN, and Cr levels when compared with the control group. Also, GSH levels were found to be reduced due to the CP treatment. Montelukast administration after CP injection ameliorated all of these parameters. Our histopathological findings (marked swelling of epithelial cells, tubular dilatation, tubular desquamation, and loss of brush border in the kidney) were consistent with the biochemical results. Conclusion: Montelukast treatment after CP injection exerted therapeutic effects against CP-induced acute kidney damage.Öğe Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study(Hindawi Ltd, 2012) Kose, Evren; Sapmaz, Hilal Irmak; Sarihan, Ediz; Vardi, Nigar; Turkoz, Yusuf; Ekinci, NihatThe effects of montelukast against methotrexate-induced liver damage were investigated. 35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx). At the end of the experiment, the liver tissues of rats were removed. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues. In addition, the liver tissues were examined histologically. MDA and MPO levels of Mtx group were significantly increased when compared to control group. In Mtx + ML group, these parameters were decreased as compared to Mtx group. Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes. The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls. ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present. It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.Öğe Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment(2023) Tanbek, Kevser; Kose, EvrenAim: Pemetrexed (PMTX) is a multi-targeted anticancer agent that exerts its antifolate effect by disrupting the folate dependent metabolic processes underlying cell proliferation. Kidney toxicity is a common side effect of anticancer agents. Chrysin (Chr) is a powerful antioxidant compound abundant in plant extracts, honey, and bee propolis. The aim of this study is to investigate the effect of the combined use of chrysin, a natural flavonoid, against the possible harmful effects of PMTX on kidney tissue. Materials and Methods: 50 Wistar albino male rats were divided; Control, Sham, PMTX, Chr, PMTX+Chr groups. Sham (1ml corn oil/day), Chr (50mg/kg/day) by oral gavage, PMTX (1mg/kg/week) by i.p., PMTX+Chr (PMTX;1mg/kg/week, Chr;50mg/kg/day) were given at the same time every day. At the end of 4 weeks of the study, kidney tissues and blood were collected. Creatinine (Cr) and blood-urea-nitrogen (BUN) analyzed in serum by ELISA. The malondialdehyde (MDA), superoxide dismutase (SOD) activities and total antioxidant status (TAS), total oxidant status (TOS), OSI also were measured in kidney tissue. Results: Indicators of oxidative stress, MDA was elevated and antioxidant activity was reduced in the PMTX groups compared to Control and Sham groups (p<0.05). In the PMTX+Chr group, MDA, BUN, Cr and TOS were decreased, SOD and TAS was increased compared to PMTX group (p <0.05). Conclusion: Chr exhibited ameliorative effects on PMTX induced nephrotoxicity increasing antioxidant activity and reducing oxidative damage.Öğe COMPARISON OF CONVENTIONAL PHYSICAL THERAPY AND MULLIGAN MOBILIZATION TECHNIQUE IN THE TREATMENT OF CERVICOGENIC HEADACHE(Turkey Assoc Physiotherapists, 2022) Argali Deniz, Mine; Kose, Evren; Ercan, Meryem; Yagar, Derya; Oner, Serkan; Ozbag, DavutPurpose: The aim of this investigate the effectiveness of the conventional physical therapy and Mulligan mobilization technique in the treatment of Cervicogenic Headache (CH) and to compare the effectiveness of these two methods. Methods: A total of 40 patients with CH were randomized into conventional physical therapy group (Group 1, n=20) and Mulligan mobilization group (Group 2, n=20). Neck lordosis, range of motion (ROM), Cervical Performance Tests, Visual Analogue Scale (VAS), Neck Disability Index, Beck Depression Scale measurements were recorded at baseline and at two weeks after the treatment. Results: VAS, Neck Disability Index and Beck Depression Scale decreased and ROM, cervical performance and lordosis angle increased significantly in both groups (p=0.010). Conclusions: Both treatments were found to have positive effects on radiological and clinical findings of CH, but Mulligan mobilization technique was found to be more effective in all evaluations except neck extension and right lateral flexion ROM measurements.Öğe Detailed Anatomical Analysis of the Sphenoid Sinus and Sphenoid Sinus Ostium by Cone-Beam Computed Tomography(Lippincott Williams & Wilkins, 2016) Yilmaz, Nesibe; Kose, Evren; Dedeoglu, Numan; Colak, Cemil; Ozbag, Davut; Durak, Mehmet AkifThe aim of this study is the evaluation of the anatomical structures of sphenoid sinus ostium used as a reference point for transsphenoidal surgery by cone beam computed tomography. The authors' study was performed using the cone-beam computed tomography images of 16 to 82-year old 200 (112 female, 88 male) patients (Newton 5G, Verona, Italy). Septum deviation of sphenoid sinus and the distance between 2 ostia were evaluated by coronal and axial sections, respectively. Pneumatization degree of sphenoid sinus, diameter of sphenoid sinus ostium, and distance lower edge of superior turbinate to sphenoid sinus ostium were measured by using sagittal sections. The sellar type was the most common pneumatization type of sphenoid sinus in authors' study. While the C-type septum deviation was observed as the most common, T-type deviation was the least type. Sphenoid sinus ostium was bilaterally in 71.5% of individuals, and it was not found in 10% of individuals included in the study. A significant decrease was determined in diameter of the left sphenoid sinus ostium with aging. The distances between 2 sphenoid sinus ostia were 7.30 +/- 2.77mm for women and 6.09 +/- 2.58mm for men, respectively. No statistical differences were found in women and men in terms of distances between the lower edge of the right and left superior turbinate and sphenoid sinus ostium on their sides. Consequently, making detailed preoperative radiological evaluation of anatomic variations of sphenoid sinus and sphenoid sinus ostium is important in terms of guiding the surgeon in the process of a successful transsphenoidal surgery.Öğe Effects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats(Taylor & Francis Ltd, 2023) Cigremis, Yilmaz; Ozen, Hasan; Durhan, Merve; Tunc, Selahattin; Kose, EvrenEffects of Caffeic acid phenethyl ester (CAPE) and/or PD98059 (PD) on the gene expression of Caveolin-1 (CAV1) and reduced glutathione (GSH), malondialdehyde (MDA), copper-zinc superoxide dismutase (CuZn-SOD), and catalase (CAT) enzyme activities were investigated in an experimental chronic renal failure model in rats. Eighty Wistar rats were divided into eight groups for a 28-day study: Control, CsA (Cyclosporine A), CsA-V (CsA solvent), CsA + PD (CsA + PD98059), CsA + PD + CAPE, CsA + CAPE, CAPE-V (CAPE solvent), and PD-V (PD98059 solvent). Serum blood urea nitrogen and creatinine levels, as well as histopathological findings indicated the development of renal failure in the CsA group. Kidney GSH levels decreased while MDA levels, CuZn-SOD, and CAT activities increased significantly in the CsA group compared to control indicating oxidative stress. CAV1 gene expression significantly decreased in the CsA group compared to the control. PD98059 and CAPE applications made positive improvements in the levels of the parameters investigated. PD98059 and CAPE applications in CsA given animals increased GSH and CAV1 gene expressions and decreased CuZn-SOD and CAT levels compared to the CsA group. In conclusion, it was shown that PD98059 and CAPE could attenuate the effects of chronic renal failure, and CAV1 is suggested as a therapeutic target and the inhibition of the p44/42 MAPK pathway may be a new approach for the treatment of renal degenerations.Öğe Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: An experimental study(Sage Publications Inc, 2016) Sapmaz, Hilal Irmak; Sarsilmaz, Mustafa; Godekmerdan, Ahmet; Ogeturk, Murat; Tas, Ufuk; Kose, EvrenAim: This study was carried out to determine the effects of formaldehyde (FA) inhalation on the humoral immunity of rats and the protective effect of Nigella sativa (NS) oil. Materials and Methods: The rats (n = 33) were divided into five groups, with five animals in the control group (FA-free air) and seven in the other four groups. Group FA I was exposed to FA (5 ppm), group FA NS I was treated with NS and exposed to FA (5 ppm), group FA2 was exposed to FA (10 ppm), and group FA + NS2 was treated with NS and exposed to FA (10 ppm). At the end of a 4-week study period, blood samples were collected. Enzyme-linked immunosorbent assay was used to determine the levels of serum total immunoglobulin A (IgA), total immunoglobulin M (IgM), total immunoglobulin G (IgG), and complement 3 (C3). Results: FA inhalation significantly increased serum IgA, IgM, and C3 levels and decreased serum IgG levels compared with the control group. NS administration decreased serum IgA, IgM, and C3 levels, which were induced by FA inhalation. Conclusion: FA inhalation significantly increased acute antibody responses and C3 levels in a dose-dependent manner compared with the control group. FA inhalation decreased the secondary immune response compared with the control group. Levels of acute antibody responses and complement following exposure to FA inhalation returned to normal following treatment with NS (immunoregulatory effect). However, NS did not affect the secondary immune response.Öğe Effects of lemon essential oil aroma on the learning behaviors of rats(Riyadh Armed Forces Hospital, 2010) Ogeturk, Murat; Kose, Evren; Sarsilmaz, Mustafa; Akpinar, Burhan; Kus, Ilter; Meydan, Sedat[Abstract Not Available]Öğe Evaluation of major coronary artery Bifurcation angles with digital angiography: A detailed study of prevalence in the Upper Euphrates Basin(Professional Medical Publications, 2022) Deniz, Gulnihal; Kavakli, Ahmet; Kucukukur, Murat; Kose, Evren; Karaca, IlginObjectives: To investigate the diversity and average values of bifurcation angles in a large population to help develop new methods. Methods: One thousand five individuals (504 females, 501 male) who visited the Cardiology Polyclinic of Firat University Hospital with the complaint of chest pain between 2010 and 2015 were evaluated retrospectively. Bifurcation angle measurements between LMCA-CX, CX-LAD, LMCA-LAD, CX-OM1, CX-OM2, LAD-D1, LAD-D2, RCA-RMD, RCA-RVD and PDA-PL were evaluated in all cases. Results: Bifurcation angles between LMCA-LAD, LMCA-Cx and LAD-Cx branches with > 90 wide angle bifurcations, and Cx-OM1, Cx-OM2, LAD-D1, LAD-D2, RCA-RMD and PDA-PL with <70 Y type bifurcation angle were found to be high in male and female individuals. The RCA-RVD in female individuals was <70 Y-type bifurcation in 14 (2.8%) people, > 70-90 T-type bifurcation in 209 (41.5%) people, and > 90 wide angle bifurcation in 281 (55.8%) people. Results for male subjects were compatible with this. The correlations of all angles were examined. Robust positive correlations (p <= 0.001) were found for the angular measurements between the main branches and the side branches (Cx-OM1, Cx-OM2, LAD-D1, LAD-D2 and RCA-RMD, PDA-PL). Conclusion: With the help of developing technology, we believe that all this coronary angiography data will guide bifurcation stent techniques, which are essential alternatives to bypass.Öğe The evaluation of the effect of vaginal delivery and aging on anal sphincter anatomy and function(Elsevier Masson, Corporation Office, 2018) Cay, Mahmut; Cetin, Aymelek; Ates, Mustafa; Koleli, Isil; Senol, Deniz; Kose, Evren; Ozgor, DincerObjective. - This study was conducted to evaluate the effect of vaginal delivery and aging on anal sphincter anatomy and function. Method. - Asymptomatic thirty women were included in this prospective study. Group 1 included 10 women (age range: 18-50) who had never been pregnant. Group 2 included 10 women (age range: 18-50) who had vaginal delivery. Group 3 included 10 women over 50 who had vaginal delivery. Results. - There was no statistically significant difference between the three groups in terms of resting and squeeze pressures. It was found that sphincter thickness showed statistically significant difference between the group 1 and group 3, and also group 2 and group 3. There was not statistically significant difference between the group 1 and group 2 in terms of sphincter thickness. There was a positive correlation between the age and sphincter thickness in all groups. In terms of sphincter thickness and pressure findings there was a positive correlation between the squeeze pressure and external anal sphincter thickness only in group 3. Conclusion. - The vaginal delivery did not have a negative influence on the structure and function of the anal sphincter in asymptomatic women. However, it was found that anal sphincter thickness changed strongly in a positive manner with aging. (C) 2018 Elsevier Masson SAS. All rights reserved.Öğe The evaluation of the effect of vaginal delivery and aging on anal sphincter anatomy and function (vol 47, pg 309, 2018)(Elsevier Masson, Corp Off, 2020) Cay, Mahmut; Cetin, Aymelek; Ates, Mustafa; Koleli, Isil; Senol, Deniz; Kose, Evren; Ozgor, Dincer[Abstract Not Available]Öğe The evaluation of the effect of vaginal delivery and aging on anal sphincteranatomy and function(Elsevıer masson, corporatıon offıce, 65 camılle desmoulıns cs50083 ıssy-les-moulıneaux, 92442 parıs, france, 2018) Cay, Mahmut; Cetin, Aymelek; Ates, Mustafa; Koleli, Isil; Senol, Deniz; Kose, Evren; Ozgor, Dincer; Simsek, Arife; Ozbag, DavutObjective. - This study was conducted to evaluate the effect of vaginal delivery and aging on anal sphincter anatomy and function. Method. - Asymptomatic thirty women were included in this prospective study. Group 1 included 10 women (age range: 18-50) who had never been pregnant. Group 2 included 10 women (age range: 18-50) who had vaginal delivery. Group 3 included 10 women over 50 who had vaginal delivery. Results. - There was no statistically significant difference between the three groups in terms of resting and squeeze pressures. It was found that sphincter thickness showed statistically significant difference between the group 1 and group 3, and also group 2 and group 3. There was not statistically significant difference between the group 1 and group 2 in terms of sphincter thickness. There was a positive correlation between the age and sphincter thickness in all groups. In terms of sphincter thickness and pressure findings there was a positive correlation between the squeeze pressure and external anal sphincter thickness only in group 3. Conclusion. - The vaginal delivery did not have a negative influence on the structure and function of the anal sphincter in asymptomatic women. However, it was found that anal sphincter thickness changed strongly in a positive manner with aging. (C) 2018 Elsevier Masson SAS. All rights reserved.Öğe The Evaluation of Vertebrobasilar Artery System in Neuro-Behcet and Behcet Disease using Magnetic Resonance Angiography(Wiley, 2014) Kose, Evren; Kamisli, Suat; Dogan, Metin; Tasolar, Sevgi; Kahraman, Aysegul; Oztanir, Mustafa Namik; Sener, SerpilThe aim of this study is the evaluation of the vertebrobasilar artery system in patients with Behcet's and Neuro-Behcet's disease. For this aim; 20 adults with clinically diagnosed Behcet's disease, 20 adults with Neuro-Behcet's disease, and 19 age-and gender-matched controls were examined by magnetic resonance angiography (MRA). During MRA, diameters of left vertebral artery (LVA), right vertebral artery (RVA), basilar artery (BA), and proximal segment (P1) of posterior cerebral artery between origin and junction with the posterior communicating artery were measured. In all groups, LVA was dominant than RVA (P < 0.05). The diameters of BA and right P1 of Neuro-Behcet's disease were larger than the other groups (P < 0.05). In addition, the diameters of left P1 of Neuro-Behcet's disease were larger but not statistically significant. There is no difference between the groups in terms of gender. Behcet's disease can affect vascular structures; therefore vertebrobasilar artery system should be examined in patients with Behcet's and Neuro-Behcet's disease. (C) 2014 Wiley Periodicals, Inc.Öğe Hepatotoxic activity of toluene inhalation and protective role of melatonin(Sage Publications Inc, 2011) Tas, Ufuk; Ogeturk, Murat; Meydan, Sedat; Kus, Ilter; Kuloglu, Tuncay; Ilhan, Necip; Kose, EvrenThis study was designed to investigate the harmful effects of toluene inhalation in the liver of rats and possible protective effects of melatonin on these detrimental effects. For this purpose, 21 adult male Wistar-albino rats were randomly divided into three equal groups. Animals in group I were used as control. The rats in group II were exposed to toluene (3000 ppm/1 hour/day) for 4 weeks, while the rats in group III were treated with melatonin (10 mg/kg/day, intraperitoneally [ip]) plus toluene inhalation. At the end of the experimental period, liver and blood samples were taken from the decapitated animals. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin levels were determined. Liver tissue sections were stained with routine histological methods and examined under the light microscope. In addition, the sections were immunohistochemically stained using avidin-biotin-peroxidase method for determination of apoptosis. The liver tissue activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and malondialdehyde (MDA) levels were also measured. Toluene inhalation significantly increased serum ALT, AST and tissue MDA, and decreased serum albumin, but did not affect serum ALP, total bilirubin levels and tissue SOD, GSH-Px and CAT activity when compared with controls. The increases in tissue MDA and serum ALT and AST levels induced by toluene inhalation were significantly inhibited by melatonin treatment. In light microscopic observations of tissues from toluene-inhaled rats, massive hepatocyte degeneration, ballooning degeneration and mild pericentral fibrosis were observed. Bax immune reactivity was also increased significantly. Melatonin treatment decreased the balloon degeneration, fibrosis and Bax immune reactivity in the liver of toluene-inhaled rats. In view of the present findings, it is suggested that melatonin has hepatoprotective effects against toluene toxicity via primarily antioxidative properties.Öğe Investigation of the Effect of Astaxanthin on Oxidative Stress in Renal Ischemia-Reperfusion Modeled Rats(Wiley, 2022) Kisaoglu, Aysegul; Kose, Evren; Yilmaz, Nesibe; Tanbek, Kevser; Yilmaz, Umit; Ozbag, Davut[Abstract Not Available]Öğe Investigation of the Effects of Isorhamnetin on Motor Function, Sedation and Analgesia in the Diabetic Rats(Karger, 2018) Kurukafa, Digdem; Kose, Evren; Parlakpinar, Hakan; Ozhan, Onural; Yasar, Seyma[Abstract Not Available]Öğe Measurement of Frontal Sinus Volume by Using Computed Tomography: A Stereological Study(Derman Medical Publ, 2015) Sapmaz, Hilal Irmak; Tugtag, Berin; Sapmaz, Emrah; Kose, Evren; Ozbag, Davut; Uysal, MuratAim: Paranasal sinuses are the anatomic regions that are frequently affected by allergic diseases and infections, thus it is substantial to comprehend the morphological structure of these regions for surgery. The aim of our study is to obtain stereological evaluation of frontal sinus volumes of female and male individuals by using computerized tomography (CT). Material and Method: This study assessed the CT images of 140 cases (70 male, 70 female) were at the age of 20 to 60 years and didn't have a disease of frontal sinus. Frontal sinus volumes were calculated stereologically on coronal plane sections by using planimetric method via Cavalieri principle. Results: When the data of male and female individuals were compared statistically; it was observed that frontal sinus volumes of men were larger. Average frontal sinus volume of women was 4,04 +/- 1,84 cm(3) and it was 7,02 +/- 2,78 cm(3) for men. Discussion: Significant advancement was obtained for paranasal sinus imaging by the use of CT, magnetic resonance imaging and three dimensional imaging techniques. In our study, frontal sinus volumes of adult individuals were measured by using planimetry method and it was detected significantly larger in men. Since frontal sinus is one of the paranasal sinuses that reveal asymmetrical development, it is clinically important to seek out its volume. In conclusion; we think that determination of the frontal sinus volume will make a major contribution to physicians for inflammatory sinus diseases, frontal sinus traumas and endoscopic sinus surgery.Öğe Protective effect of astaxanthin on testis torsion/detorsion injury through modulation of autophagy(Mre Press, 2024) Yilmaz, Nesibe; Yildiz, Azibe; Tanbek, Kevser; Kisaoglu, Aysegul; Yilmaz, Umit; Kose, EvrenA significant clinical condition known as testicular torsion leads to permanent ischemic damage to the testicular tissue and consequent loss of function in the testicles. In this study, it was aimed to evaluate the protective effects of Astaxanthin (ASTX) on testicular damage in rats with testicular torsion/detorsion in the light of biochemical and histopathological data. Spraque Dawley rats of 21 were randomly divided into three groups; sham, testicular torsion/detorsion (TTD) and astaxanthin + testicular torsion/detorsion (ASTX + TTD). TTD and ASTX + TTD groups underwent testicular torsion for 2 hours and then detorsion for 4 hours. Rats in the ASTX + TTD group were given 1 mg/kg/day astaxanthin by oral gavage for 7 days before torsion. Following the detorsion process, oxidative stress parameters and histopathological changes in testicular tissue were evaluated. Malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly decreased in the ASTX group compared to the TTD group, while superoxide dismutase (SOD), glutathione (GSH) and total antioxidant status (TAS) levels were increased ( p < 0.05). Moreover, histopathological changes were significantly reduced in the group given ASTX ( p < 0.0001). It was determined that ASTX administration increased Beclin-1 immunoreactivity in ischemic testicular tissue, while decreasing caspase-3 immunoreactivity ( p < 0.0001). Our study is the first to investigate the antiautophagic and antiapoptotic properties of astaxanthin after testicular torsion/detorsion based on the close relationship of Beclin-1 and caspase-3 in ischemic tissues. Our results clearly demonstrate the protective effects of ASTX against ischemic damage in testicular tissue. In ischemic testicular tissue, ASTX contributes to the survival of cells by inducing autophagy and inhibiting the apoptosis.Öğe The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats(Sage Publications Inc, 2016) Meydan, Sedat; Nacar, Ahmet; Ozturk, Hasan Oktay; Tas, Ufuk; Kose, Evren; Zararsiz, Ismail; Yilmaz, NigarCaffeic acid phenethyl ester (CAPE) has antioxidant and anti-inflammatory properties. The aim of this study is to examine the negative effects of toluene on kidney tissues and functions and to investigate the protective effects of CAPE against toluene-induced nephrotoxicity in rats. A total of 21 male Wistar rats were divided into three groups of equal number in each. The rats in group I were the controls. Toluene was intraperitoneally injected into the rats in group II with a dose of 500 mg/kg. Rats in group III received CAPE daily while exposed to toluene. After 14 days of experimental period, all rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and malondialdehyde (MDA) levels were studied in the rat kidneys. Blood urea nitrogen (BUN) and serum creatinine levels were measured for renal function. The CAT and SOD enzyme activities and serum creatinine levels were significantly increased in rats treated with toluene when compared with the controls. But GSH-Px activity, MDA, and BUN levels showed statistically nonsignificant changes. However, increased CAT and SOD enzyme activities and decreased serum creatinine levels were detected in the rats that received CAPE while exposed to toluene. The GSH-Px activity and MDA and BUN levels in the same group did not show statistically significant changes. The results of our study demonstrated that toluene damages kidney tissue and is a nephrotoxic substance. CAPE was able to prevent the renal damage as antioxidant, antitoxic, and nephroprotective agent.Öğe Protective effects of molsidomine against doxorubicin-induced renal damage in rats(Canadian Soc Clinical Investigation, 2016) Oguz, Fatih; Beytur, Ali; Sarihan, Ediz; Oguz, Hilal K.; Bentli, Recep; Samdanci, Emine; Kose, EvrenPurpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats. Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined. Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage. Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted.
