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    Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
    (Sciendo, 2021) Kucuk, Adem; Baykara, Rabia Aydogan; Tuzcu, Ayca; Omma, Ahmet; Cure, Medine Cumhur; Cure, Erkan; Acet, Gunseli Karaca
    Introduction. Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B-12 (VB), vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and methods. The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results. The VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p<0.001), VD (12.5 [3.0-45.0] vs 20.0 [5.0-54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0-86.0] vs 32.0 [7.1-120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015-1.058, p<0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS. Conclusions. There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not be a risk factor for FS etiopathogenesis.
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    Effect of amyloidosis and proteinuria on augmentation index in patients with familial mediterranean fever
    (2019) Gurbuz, Ahmet Seyfeddin; Ozturk, Semi; Uslu, Ali Uğur; Efe, Suleyman Cagan; Ahbab, Elbis; Kirma, Cevat; Kucuk, Adem
    Aim: There is a common belief that creativity and artistic talent/creativity are related to psychopathology. Mood disorders are more prominent in studies about relations between creativity and psychopathology. Also patients may be more productive during mania and hypomania periods of bipolar mood disorder. Considering these data, the purpose of this study was to investigate whether there is a predisposition to bipolar disorder in people with artistic creativity. Materials and Methods: A total of 157 students were selected randomly from the Art department and 157 from different departments including Faculties of Law, Science and Literature and Education. Art students had proven their artistic competence by two stage examination. Groups were compared based on mood disorder questionnaire (MDQ) and bipolarity predisposition factors. SPSS 22.0 was used for statistical analyses. Chi-square analysis was used to compare case-control groups according to demographic characteristics.Results: There were no significant differences between the groups in terms of age, sex, education, smoking, marital status, family history of psychiatric disorder. The number of psychiatric admissions were higher in the students of art (p=0.026). Alcohol-substance use was higher among students of Art (p=0.001). The MDQ scale result was 50.3% positive for Art students and 26.8% positive for students from different departments. MDQ scale, the predisposition of bipolar disorder was found to be significantly higher in Art students.Conclusion: The high prevalence of bipolarity features with MDQ scale in art students supports the relationship between artistic talent / creativity and bipolar disorder.
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    Evaluation of frequency of irritable bowel syndrome in patients with chronic urticaria
    (2018) Kucuk, Adem; Unal, Mehmet; Kaya Islamoglu, Zeynep Gizem; Tuncez Akyurek, Fatma
    Aim: Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. Urticaria is a disease with papules and plaques accompanied by pruritus and edema. In this study, the relationship between these two diseases, which have many common features, was evaluated. Material and Methods: Patients with urticaria and volunteers who did not have any dermatologic disease were included in the study. Participants were assessed for diagnosis of IBS according to Rome III diagnostic criteria. In addition, findings supporting IBS diagnosis, and fecal shape and consistency were evaluated. Results: Fifty urticaria patients (18 males - 36% and 32 females - 64%) and 70 volunteers (38 males - 54.3% and 32 females - 45.7%) were evaluated. The mean age of the urticaria group was 34.8 ± 15.0; the mean age of the control group was 25.8 ± 10.9. IBS was detected in 34 (68%) patients in the urticaria group; and in 22 (31.4%) controls (p <0.001). Diagnosis-supporting findings were more frequently detected in the group of urticaria (p values respectively: 0.037; < 0.001; 0.036; 0.050). It was observed that the higher the serum IgE level, the higher the incidence of IBS in chronic urticaria patients ( p: 0.02; eta: 0.206). Conclusion: IBS was observed more frequently in urticaria patients. Diagnosis-supporting findings for IBS were found more frequently in urticaria patients. Serum IgE values also seem to be associated with IBS. These results indicate an association between chronic urticaria and IBS. For this reason, the presence of IBS in patients with chronic urticaria diagnosis should be questioned.
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    The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis
    (Tubitak Scientific & Technological Research Council Turkey, 2021) Aydogan Baykara, Rabia; Kucuk, Adem; Tuzcu, Ayca; Tuzcu, Goksel; Cure, Erkan; Uslu, Ali Ugur; Omma, Ahmet
    Background/aim: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS. Materials and methods: Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods. Results: Visfatin levels of the patients were significantly higher than controls (p < 0.001). FMD values in patients with AS were significantly lower (p = 0.007) whereas cIMT were significantly higher than the controls (p = 0.003). There was a negative relationship between FMD with visfatin levels (p = 0.004), BASDAI (p = 0.010), and BASFI (p = 0.007). There was a positive relationship between cIMT with visfatin (p = 0.005), BASDAI (p < 0.001), and BASFI (p < 0.001). There was a positive relationship between visfatin with BASDAI (p < 0.001), and BASFI (p < 0.001). Conclusion: Visfatin levels are increased and associated with impaired FMD and increased cIMT in patients with AS. Increased visfatin levels may be associated with subclinical atherosclerosis in AS.