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    Factors affecting anxiety, depression, and stress among patients with hepatocellular carcinoma during COVID-19 pandemic
    (Verduci Publisher, 2023) Akbulut, S.; Tamer, M.; Kucukakcali, Z.; Akyuz, M.; Saritas, H.; Bagci, N.; Ciftci, F.
    - OBJECTIVE: Patients with chron-ic disease whose treatments are limited may ex-perience depression, anxiety, and stress-related symptoms, as well as an increase in the levels of these conditions. This study aims to determine the factors affecting the depression, stress, and anxiety levels of hepatocellular carcinoma (HCC) patients due to the fear of COVID-19 exposure.PATIENTS AND METHODS: 118 patients with ad-vanced HCC treated with non-transplant treatment options or on the waiting list due to the lack of a do-nor were enrolled. To evaluate the stress, depres-sion, and anxiety levels during the COVID-19 pro-cess, Depression Anxiety Stress Scales (DASS-21) and the Coronavirus Anxiety Scale (CAS) were ad-ministered to 118 patients through a face-to-face interview. Sociodemographic and clinical charac-teristics were recorded, and the primary endpoint measure was the total score of DASS. In addition, the multilayer perceptron (MLP) model was con-structed to predict the scores of the DASS-21 total.RESULTS: There were significant differences be-tween DASS depression (p=0.010; p=0.030) DASS anxiety (p=0.010; p=0.010) and DASS total (p=0.046; p=0.023) scores in terms of gender and protective effect of the vaccine. Also, a significant difference between gender for the CAS scale was determined (p=0.044). The median score of the DASS total in the COVID-19 group was higher than in the non-COVID-19 group; however, the increase was not sig-nificant. MLP model revealed that chronic disease, gender, age, place of residence, smoking, type of vaccine, and COVID-19 exposure were the most im-portant predictors for the DASS total. CONCLUSIONS: Chronic disease, gender, and age were prominent factors in predicting the DASS-21 total score in HCC patients. There-fore, the crucial factors were clinically consid-ered for managing depression, stress, and anxi-ety in HCC patients.
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    Therapeutic effects of cinnamon bark oil on sciatic nerve injury in rats
    (Verduci Publisher, 2023) Ozhan, O.; Izci, S. F.; Huz, M.; Colak, M.; Kucukakcali, Z.; Parlakpinar, H.
    - OBJECTIVE: The aim of this study was to investigate the effects of cinnamon bark essential oil (CBO) on analgesia, motor activity, balance, and coordination in rats with sciatic nerve damage. MATERIALS AND METHODS: Rats were divided into three groups as simply randomized. The right sciatic nerve (RSN) of the Sham group was explored. Only vehicle solution was applied for 28 days. The RSN of the sciatic nerve injury (SNI) group was explored. Damage was created by unilateral clamping, and vehicle solution was applied for 28 days. The RSN of the sciatic nerve injury+cinnamon bark essential oil (SNI+CBO) group was explored. SNI was created by unilateral clamping and CBO was applied for 28 days. In the experiment study, motor activity, balance, and coordination measurements were made with rotarod and accelerod tests. A hot plate test was performed for analgesia measurements. Histopathology studies were carried out with the sciatic nerve tissues.RESULTS: In the rotarod test, there was a statistically significant difference between the SNI group and the SNI+CBO group (p<0.05). According to the accelerod test findings, there was a statistically significant difference between the SNI group with the Sham and SNI+CBO groups. In the hot plate test, there was a statistically significant difference between the SNI group with the Sham and SNI+CBO groups (p<0.05). In comparison to the Sham group and the SNI group, the SNI+CBO group was shown to have the greatest expression level of vimentin.CONCLUSIONS: We have concluded that CBO can be used as an adjuvant treatment in cases of SNI, increased pain, nociception, impaired balance, motor activity, and coordination. Our results will be supported by further studies.