Yazar "Kulaksizoglu, Sibel" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Changes in serum BDNF levels after treatment of panic disorder patients
    (2019) Kulaksizoglu, Sibel; Kulaksizoglu, Burak
    Aim: Panic disorder is a significant psychiatric disorder that more frequently occurs in women, with daily attacks such as fear of death, limiting the patient’s daily life. It is often associated with agoraphobia. The aim of this study was to investigate the relationship between BDNF levels and the clinical features of panic disorder.Material and Methods: The study was carried out between January 2015 and July 2015 with 42 female patients and 38 healthy females who were admitted to Psychiatry Outpatient Clinic. The patients who were diagnosed with panic disorder without agoraphobia included in the study. The Panic Disorder Severity Scale (PDSS) was applied to the patients. Serum BDNF was measured by sandwich ELISA.Results: The mean age of the 38 female patients was 35.1±11.5 years. The mean age of the control group of 38 healthy women was 34.9±9.82 years. Serum BDNF levels measured before treatment were significantly lower than BDNF levels measured after treatment (p 0.001). Serum BDNF levels measured before treatment were significantly lower than BDNF levels of the control group (p0.001). While there was a statistically significant negative correlation between BDNF levels and PDSS scores before treatment.Conclusion: Serum BDNF levels were significantly increased after treatment. The PDSS scores also decreased significantly after treatment. These results inform us about the effectiveness of the treatment. BDNF levels may also be considered as an indicator of the clinical follow-up of the panic disorder without agoraphobia.Keywords: Panic disorder; brain-derived neurotrophic factor; agoraphobia.
  • Küçük Resim
    Öğe
    High neutrophil to lymphocyte ratio and low mean platelet volume level in autism spectrum disorders
    (2019) Kulaksizoglu, Sibel; Koparan, Cem
    Aim: A growing number of studies have indicated that ASD is associated with neuro-inflammation. Recent research has indicated that complete blood count (CBC) may be used for assessing inflammatory markers, offering a cheap, simple and reproducible alternative that is also suitable for routine application. In this study, we evaluated complete blood count (CBC) data in children with ASD, aiming to explore associations between ASD and inflammationMaterial and Methods: Patients diagnosed with ASD between 01.01.2018 and 31.08.2019 were included in the study. CBC results of patients from their initial visit to the clinic were analyzed. The control group consisted of children with matching age and gender visiting the clinic for general examination. CBC parameters of both the study and control groups were evaluated statistically. Results: 67 children diagnosed with ASD and 67 healthy children were included in the study. In the ASD group, the neutrophil/lymphocyte ratio (NLR) was significantly higher than in the control group (p0.001). The cut-off value for NLR was determined as 2.32. The levels of mean platelet volume (MPV) were significantly lower in the ASD group compared to the control group (p0.001). The cut-off value for MPV was determined as 11.75 fl. Conclusion: NLR and MPV measurements, which are simple and readily-available laboratory tests, may serve as important biomarkers for diagnosis of ASD. Increased NLR and lowered MPV levels may be used as screening tools and early intervention predictors for ASD. Further research with a larger sample size may clarify the involvement of inflammation in ASD.