Yazar "Kurtoglu, Erdal" seçeneğine göre listele

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    Analysis of changes in brain morphological structure of taekwondo athletes by diffusion tensor imaging
    (Elsevier, 2023) Kurtoglu, Erdal; Payas, Ahmet; Duz, Serkan; Arik, Mustafa; Ucar, Ilyas; Tokmak, Turgut Tursem; Erbay, Mehmet Fatih
    Objective: Taekwondo, which is the most preferred sport among the martial arts, is known to improve individuals physically, spiritually and mentally. The aim of this study is to reveal the effect of teakwondo sport on the brain and brain structures.Design;: 30 taekwondo athletes and 15 control groups were included in this study. Diffusion tensor MR images of each participant were taken. The information was obtained by the self-declaration of the athletes, whether they were sports years, amateur or elite.Method: Total brain volume and volumes of white matter, gray matter, frontal lobe, precentral gyrus, cortico-spinal tract, basal nuclei, postcentral gyrus, hippocampus and amigdala and the ratio of these volumes to total brain volume were evaluated statistically between the groups using MriCloud software and ROIEditor program.Results: An increase in total brain volume, gray matter, frontal lobe and precentral gyrus volume in athletes was associated with taekwondo training. When the ratio of brain parts to total brain volume was examined, it was determined that there was a difference in the ratio of gray matter, white matter volumes in amateur athletes, right frontal lobe, left corticospinal tract, right postcentral gyrus volumes in elite athletes, and left postcentral gyrus volumes of both athletes compared to sedentary individuals.Conclusions: The increase in the volume of gray matter, frontal lobe, postcentral gyrus and corticospinal tract together with the brain volume shows that taekwondo exercise contributes to physical, spiritual and mental development.
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    Extracorporeal photopheresis in steroid-refractory chronic graft-versus-host disease: A retrospective multicenter study
    (Pergamon-Elsevier Science Ltd, 2021) Dal Sinan, Mehmet; Batgi, Hikmettullah; Erkurt, Mehmet Ali; Hindilerden, Ipek Yonal; Kuku, Irfan; Kurtoglu, Erdal; Kaya, Emin
    Background and objectives: Extracorporeal photopheresis (ECP) is a treatment strategy in steroid-refractory chronic graft-versus-host disease (cGvHD). In this study, we aimed to share our multicenter experience using ECP in our steroid-refractory cGvHD patients. Materials and methods: In this multicenter observational retrospective study with the participation of four Turkish transplant centers, 100 patients with the diagnosis of steroid-refractory cGvHD who underwent ECP were analyzed. All ECP procedures were performed with the off-line system. Results: Severe cGvHD was observed in 77 % of the patients. 50 % of the patients had more than 1 organ involvement. The overall response rate in cGvHD was 58 %, and the complete response (CR) rate was 35 %. The skin was the most involved organ, with a response rate of 61.2 % (CR rate 30.6 %) in cGvHD. At a median 13 months (1-261) follow-up, overall survival (OS) was 41 % (n = 41) and the mortality rate was 59 % (n = 59). Median overall survival (OS) was 2 months for non-responders and 91 months for responders (p < 0.001). Significant OS differences were observed for patients responding to ECP in cGvHD (HR = 4.1, p = 0.001) patients. Conclusions: ECP is a good therapeutic alternative and could be used earlier in patients with steroid-resistant cGvHD.
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    Extracorporeal photopheresis in the treatment of acute graft-versus-host disease: A multicenter experience
    (Pergamon-Elsevier Science Ltd, 2021) Batgi, Hikmettullah; Dal, Mehmet Sinan; Erkurt, Mehmet Ali; Kuku, Irfan; Kurtoglu, Erdal; Hindilerden, Ipek Yonal; Kaya, Emin
    Background and objectives: Extracorporeal photopheresis (ECP) is one of the second-line treatment strategies in steroid-refractory acute graft-versus-host disease (aGvHD). We aimed to share our multicenter experience using ECP in our steroid-refractory aGvHD patients. Materials and methods: A retrospective observational series of 75 aGvHD patients from 4 transplant centers were analyzed. All ECP procedures were performed with the off-line system. All patients received ECP as second-line therapy. Results: 74.7 % of aGvHD patients were grade 3 or 4. The overall response rate was 42.7 % (32/75) in aGvHD including 17 complete responses (22.7 %). Median follow-up was 6 months (range, 1-68). Median overall survival (OS) was 5 months for non-responders and 68 months for responders (p < 0.001). Twenty-seven (36 %) patients are alive, and 48 (64 %) patients have died. Conclusions: Early initiated ECP could be an effective treatment alternative in patients with steroid-refractory aGvHD.