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    Effects of endoscopic endonasal sinus surgery on nasal flora in patients with chronic rhinosinusitis with nasal polyps
    (2019) Ulusoy, Bulent; Ersoy Callioglu, Elif; Muderris, Tuba; Bozdemir, Kazim; Oguzhan, Tolga; Kutluhan, Ahmet; Acikgoz, Ziya Cibali; Korkmaz, Mehmet Hakan
    Aim: This study aimed to evaluate the alterations in the nasal flora in patients who underwent endoscopic endonasal surgery for chronic rhinosinusitis with nasal polyps (CRSwNP). Material and Methods: This prospective study included 30 patients diagnosed with CRSwNP who were resistant to medical treatment and recommended for surgery. The nasal cavity was sampled two times, first preoperatively on the day of operation and postoperatively in the 4th week. Patients were divided into two groups according to their culture results, including normal flora bacteria and potential pathogen production. Results: In the preoperative swab samples, 3 (11.1%) patients had no bacterial growth, 16 (59.3%) patients had a normal flora, and potential pathogens were detected in 8 (29.6%) patients. However, postoperatively, 3 (11.1%) patients had no bacterial growth, 13 (48.1%) patients had a normal flora, and potential pathogens were detected in 11 (40.7%) patients during the postoperative period. No significant difference was found between preoperative and postoperative culture results in terms of the number of patients with normal flora, potential pathogens, and no bacterial growth (p=0.676). The most common microorganism in the normal flora group preoperative and postoperative period was coagulase-negative Staphylococcus (77.8%, 51.9%, respectively), and the most common microorganism in the potential pathogen group was Staphylococcus aureus (18.5% and 25.9%, respectively). Comparing preoperative and postoperative culture results according to isolated potential pathogen microorganism types, no statistically significant difference was observed for any microorganism in the potential pathogen group (p>0.05).Conclusion: As a result, no correlation between nasal polyps’ surgery and potential pathogens was detected. Keywords: Chronic rhinosinusitis; culture; nasal polyps; flora; potential pathogens; bacteria; Staphylococcus aureus; coagulase; transnasal endoscopic surgery; pseodomanas.
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    Evaluation of balance with video head impulse test and vestibulospinal tests in patients with substance use disorder
    (2022) Aydin, Ahmet; Kutluhan, Ahmet; Sahiner, Safak; Kaya, Sule
    Aim: The aim of this study was to investigate the long-term complications of substance use on the vestibular system. Substance use disorders are thought to impair the vestibular apparatus as well as the auditory system. Materials and Methods: Sixty-five cases with a history of non-alcohol drug addiction who survived the withdrawal phase and 22 healthy controls were included in the study. The cases were categorized into 2 different subgroups as those who had used only opioids ("opioid") and those who had used an opioid and chemical simultaneously or otherwise ("opioid &chemical"). Vestibulospinal tests and video Head Impulse Test (vHIT) were performed on all participants and the results were analyzed. Results: A total of 65 (61 males/4 females, mean age was 25 ± 3.95 years) cases and 22 (males, mean age was 25 ± 3.3 years) healthy controls were included in the study. The mean age of the "opioid" group (n=33) was 25 ± 3.95 years, and the mean age of the "opioid & chemical" group (n=32) was 25 ± 3.13 years (p>0.05). When the cases and controls were evaluated according to vestibulospinal tests, a high level statistically significant difference was observed (p<0.001), but no significant difference was found according to vHIT. Conclusion: This is the first study evaluating long-term vestibular functions with the vHIT test in patients with substance use disorder. Although the results suggest that there is no vestibulo-ocular reflex (VOR) involvement in the groups according to the vHIT, it has been revealed that substance use has negative effects on balance and walking.