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  • Küçük Resim
    Öğe
    Prognostic factors and classification of pathological single and multiple N1 in non-small cell lung cancer patients
    (2021) Erdogu, Volkan; Kutluk, Ali Cevat; Pekcolaklar, Atilla; Aker, Cemal; Sansar, Deniz; Onay, Selin; Saydam, Ozkan; Metin, Muzaffer
    Aim: We compared outcomes between “single pathologic N1” (pN1a) and “multiple pathologic N1” (pN1b) patients and investigated whether all pN1b patient subgroups had the same outcomes in non-small cell lung cancer (NSCLC). Materials and Methods: We retrospectively analyzed 487 pN1 patients with NSCLC between 2010 and 2016. There were 284 single N1 (pN1a Group) and 203 multiple N1 (pN1b Group) patients. pN1b Group was divided into two subgroups; invasion of intraparenchymal lymph nodes (pN1b-without hilar group, n=48) and pN1b provided that one of the metastatic lymph nodes LN(s) has to be 10 and/or 11 (pN1b with hilar group, n=155). Overall survival (OS) and disease-free survival (DFS) rates were compared between subgroups of N1 patients. Results: The mean age was 59.3 ± 8.3. The majority of the patients were male (n=462, 94.9%). The OS rate of pN1 patients was 53.2%, while the DFS rate was 48.8%. Multivariate analysis showed that adenocarcinoma histology (p=0.030), presence of pleural invasion (p=0.001) and perineural invasion (p=0.034) had worse effect on overall survival in pN1 patients. Both OS and DFS rates were statistically better in the pN1a Group than the pN1b Group (OS; 56.2% vs 48.3% p=0.03; DFS; 51.9% vs 44.4%, p=0.03). Although both OS and DFS rates were better in the pN1b-without hilar group patients than in pN1b-with hilar group, it was not significant (OS; 56.0% versus 44.5% p=0.187; DFS; 53.9% vs 40.6%, p=0.115). Conclusion: The pN1a Group had significantly better survival than the pN1b Group. However, the patients in the latter group without hilar LN(s) invasion exhibited better survival rates than those with hilar LN(s) involvement, although this was not significant. We think that the survival advantage in multiple N1 without hilar lymph node involvement should be evaluated with a larger patient series.
  • Küçük Resim Yok
    Öğe
    Surgery for Pulmonary Hydatidosis in Turkey in 2014: A Nationwide Study
    (Aves, 2019) Gulhan, Sakir Erkmen; Kilicgun, Ali; Samancilar, Ozgur; Altinok, Tamer; Kutluk, Ali Cevat; Baysungur, Volkan Selami; Celik, Muhammet Reha
    OBJECTIVES: Turkey remains among the countries where hydatid disease is endemic. In this study, it was aimed to determine the number of operations performed for the treatment of pulmonary hydatid disease in Turkey during 2014 and to present the distribution of these operations according to the different regions of the country. MATERIALS AND METHODS: The Turkish Thoracic Society Thoracic Surgery Study Group connected with the thoracic surgeons in each city through telephone. A data set was sent by email. The age, sex, contact with animals that might be a risk of gaining the hydatid disease, the side of the disease, the type of surgical method, other organ involvement were recorded and collected from each data set to form the final data, and the results were evaluated. Turkey comprises of 81 cities that are grouped in seven different regions. The number of operations was calculated for each city and region to present the distribution. RESULTS: Overall, 101 centers from 81 cities were considered in the study. A total of 715 pulmonary hydatid cyst operations were performed in 690 patients during the study period. The most common operation technique was cystotomy and capitonnage through thoracotomy (76%). The highest incidence rate of operated patients was in the Eastern Anatolian Region (2.15 patients per 100 000 person-years). CONCLUSION: Pulmonary hydatid disease still has a high incidence rate particularly in the southeast and east of Turkey, which are mainly rural areas and where stockbreeding is very common. Cystotomy and capitonnage is still the most common surgical method used to treat pulmonary hydatid cysts. Preventive methods should be performed strictly in these cities and regions to decrease the risk of infection.