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    Oral hygiene in children with epilepsy: Effect of interleukin-1? and VEGF levels in gingival crevicular fluid
    (Polish Dental Soc, 2017) Duruk, Gulsum; Aksoy, Hulya; Gurbuz, Taskin; Laloglu, Esra; Tan, Huseyin
    Background. The biochemical parameters in gingival crevicular fluid (GCF) are affected by some systemic diseases and poor oral hygiene. Objectives. The aim of this study was to evaluate the total amounts of Interleukin-1 beta (IL-1 beta) and vascular endothelial growth factor ( VEGF) in GCF in children with epilepsy. Material and methods. Eighty children with epilepsy in a seizure-free period ( the test group) and 80 healthy children ( the control group) were evaluated. The children with epilepsy were taking valproic acid (VPA), carbamazepine, phenobarbital, and the combinations of these drugs. Gingival index (GI), plaque index (PI), probing depth (PD) and clinical attachment level (CAL) were measured. GCF was collected and its volume was measured. The total amounts of IL-1 beta and VEGF in the GCF were analyzed in the Biochemistry Laboratory at Ataturk University. Results. The biochemical (IL-1 beta and VEGF) and clinical parameters (GI, PI, PD and GCF volume) were significantly higher in children with epilepsy compared to healthy children (p < 0.0001). When the epilepsy patients were divided into groups according to the drug used in this study, there were no significant differences in the GCF levels of IL-1 beta and VEGF among the drug groups. Also, a significant gingival enlargement in the patient population was not recorded. Conclusions. According to these results, it may be suggested that patients need optimal oral care in epilepsy.
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    Relationship Between Dental Caries and YKL-40 Levels in Saliva
    (Journal Pedodontics Inc, 2022) Duruk, Gulsum; Laloglu, Esra
    Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages and regulates inflammation and immune responses. The aim of this study was to investigate YKL-40 levels in saliva and compare the level of this mediator in healthy and unhealthy oral cavity. Study design: 80 children (42-girl, 38-boy), aged 6-15 (mean +/- SD: 9.35 +/- 2.08) were included in this cross-sectional study. The children were divided into four groups: Group-I (control, n=20, dmft/DMFT=0), Group-II (n=20, exist of dental caries), Group-III (n=20, exist of advanced dental caries without pulp exposure), and Group-IV (n=20, exist of advanced dental caries with pulp exposure). The dmft/DMFT, dmfs/DMFS, and the number of advanced dental caries according to the ICDAS and pufa/PUFA index were recorded. Saliva was collected and YKL-40 concentrations were measured. Results: The highest level of YKL-40 was obtained in Group IV, followed by Groups III, II, and I, respectively (p<0.01). There was a positive correlation between YKL-40 and the number of caries There were no statistically significant difference in YKL-40 levels in terms of age and gender (p>0.05). Conclusions: The advanced dental caries with pulp exposure may play an important role in the increasing levels of YKL-40 in saliva.