Yazar "MacWalter, RS" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Cerebral haemorrhage - Parenchymal intracranial haemorrhage(Karger, 2001) MacWalter, RS; Ersoy, Y; Wolfson, DRWhile there have been substantial improvements in the management of patients with cerebral infarction and there are likely to be further improvements over the next decade, the same may not be true for cerebral haemorrhage. Diagnostic facilities and neurosurgical techniques have improved but not all patients are benefiting from these, The current literature is reviewed, Further controlled trials of the utility of modern neurosurgical techniques are urgently required as at present no therapeutic intervention holds out hope for these patients other than optimum medical management. The main focus must be on prevention. Copyright (C) 2001 S.Karger AG, Basel.Öğe Converting enzyme inhibitor or AT1-receptor blocker for decreasing long-term mortality in patients, with stroke history and renal dysfunction?: Response(Lippincott Williams & Wilkins, 2003) MacWalter, RS; Wong, KYK; Wong, SYS; Struthers, AD; Ersoy, Y[Abstract Not Available]Öğe Does renal dysfunction predict mortality after acute stroke? A 7-year follow-up study(Lippincott Williams & Wilkins, 2002) MacWalter, RS; Wong, SYS; Wong, KYK; Stewart, G; Fraser, CG; Fraser, HW; Ersoy, YBackground and Purpose-The purpose of this study was to investigate renal function as a long-term predictor of mortality in patients hospitalized for acute stroke. Methods-This was a cohort study done in a Scottish tertiary teaching hospital. Participants included 2042 (993 male) unselected consecutive stroke patients (mean age, 73 years) admitted to hospital within 48 hours of stroke between 1988 and 1994. Follow-up was up to 7 years. Main outcome measure was all-cause mortality. Results-The total number of deaths at the end of follow-up was 1026. Most subjects (1512) had creatinine < 124 mumol/L. The mean calculated creatinine clearance was 54.8 mL/min (SD, 23 mL/min). Renal function indexes were analyzed by quartiles with Cox proportional-hazards model. Stroke survivors had higher calculated creatinine clearance and lower serum creatinine, urea, and ratios of urea to creatinine. Calculated creatinine clearance greater than or equal to51.27 mL/min significantly predicted better long-term survival in these stroke patients even after adjustment for confounders (age, neurological score, ischemic heart disease, hypertension, smoking, and diuretic use). Similarly, creatinine greater than or equal to119 mumol/L [relative risk (RR), 1.59; 95% confidence interval (CI), 1.32 to 1.92], urea 6.8 to 8.9 mmol/L (RR, 1.34; 95% CI, 1.09 to 1.65) or greater than or equal to9 mmol/L (RR, 1.74; 95% CI, 1.42 to 2.13), and ratio of urea to creatinine greater than or equal to0.08573 mmol/mumol (RR, 1.24; 95% CI, 1.03 to 1.50) remained significant predictors of mortality after adjustment for confounders. Conclusions-After acute stroke, patients with reduced admission calculated creatinine clearance, raised serum creatinine and urea concentrations (even within conventional reference intervals), and raised ratio of urea to creatinine had a higher mortality risk. This finding may be used to stratify risk and target interventions, eg, the use of angiotensin-converting enzyme inhibitors.Öğe Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis(British Med Journal Publ Group, 2002) Ersoy, Y; Özerol, E; Baysal, Ö; Temel, I; MacWalter, RS; Meral, Ü; Altay, ZEObjective: To assess and compare serum nitrate and nitrite levels in patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA), and osteoarthritis (OA). Methods: Thirty five patients with RA, 32 patients with AS, and 36 patients with OA were entered into this study. In addition, 30 healthy volunteers acted as a control group. Concentrations of nitrate and nitrite in serum were determined by direct and indirect Griess reactions. C reactive protein and erythrocyte sedimentation rate levels were determined as markers of systemic activity of disease (SAD) in RA and AS groups. Results: Serum nitrate and nitrite levels were found to be higher in patients with AS and RA than in the OA group (p <0.01). In addition, serum nitrate and nitrite levels were higher in all three groups than in the control group (p <0.01). Moreover, serum nitrate and nitrite levels were higher in patients who had SAD than in those who had not in the RA and AS groups (p <0.01 and p <0.05, respectively), and there was a correlation between serum nitrate and nitrite concentrations and SAD variables in patients with RA (Spearman's r(s)=0.414, p <0.05 and r(s)=0.408, p <0.05, respectively) and AS (r(s)=0.421, p <0.05 and r(s)=0.412, p <0.05, respectively). Conclusion: The findings suggest that nitrate and nitrite production is enhanced in patients with inflammatory arthritis compared with OA. In addition, serum nitrate and nitrite levels are enhanced in patients with RA, AS, and OA compared with healthy subjects. Furthermore, there is a correlation between the SAD variables and serum nitrate and nitrite levels in patients with RA and AS.
