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Öğe The effects of hesperidin on idiopathic pulmonary fibrosis evaluated by histopathologial-biochemical and micro-computed tomography examinations in a bleomycin-rat model(Scientific Publishers of India, 2016) Görmeli C.A.; Saraç K.; Çiftçi O.; Timurkaan N.; Malkoç S.Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive parenchymal lung disease. The pathology is characterized by recurrent injury to microscopic alveolar epithelial cells. These injuries activate inflammatory cells, resulting in the proliferation of fibroblasts and alveolar tissue damage. Interstitial inflammation, advanced oxidative stress, and abnormal antioxidant activity were demonstrated to be the main causes of IPF. Hesperidin (HP) is a bioflavonoid with anti-inflammatory, antioxidant, anticarcinogenic, and analgesic actions. HP may be able to prevent pulmonary fibrosis, and may ultimately lead to healthy lung function. We hypothesized that HP could prevent Bleomycin (BLC)- induced pulmonary fibrosis due to its biochemical, antioxidant, and anti-inflammatory properties and may ultimately lead to healthy lung function. Based on these findings, we hypothesized that HP could prevent BLC-induced pulmonary fibrosis due to its biochemical, antioxidant, and anti-inflammatory properties. The animals were divided into 4 groups with 14 rats per group. The experimental treatments were as follows: Control, BLC, HP, and BLC+HP. Six of the 14 lungs in each group were sent for micro- CT analysis. The remaining 8 lung specimens were harvested for histopathological and biochemical analyses. BLC-treated rats showed marked histopathological changes in the lungs. In these rats, thickening of interalveolar septa due to macrophage and lymphocyte infiltration, as well as fibroblast proliferation, were observed. Histopathological changes were less severe in the BLC+HP group compared with the BLC group. HP treatment led to a decrease in lipid peroxidation and an increase in antioxidant status compared with the BLC group. Also micro-CT showed a significant positive correlation with histopathological and biochemical results. To the best of our knowledge, this is the first study to evaluate the beneficial effects of HP against pulmonary fibrosis using histopathological, biochemical, and micro-CT analyses and HP successfully minimized the severity of BLC-induced lung injury, which was used as a model for IPF. © 2016, Scientific Publishers of India. All rights reserved.Öğe Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion(Dental Press International, 2022) Çamili Y.; Malkoç S.; Taşlidere A.; İleri Z.; Guler O.C.Objective: This study aimed to evaluate the effects of systemic teriparatide on sutural bone formation after premaxillary suture expansion in rats. Material and Methods: Twenty Wistar male rats (8–10 weeks old) were randomly divided into two groups, namely, control (C, n=10) and teriparatide (T, n=10). An expansion force was ap-plied to the maxillary incisors using helical spring for a sev-en-day expansion period, for both groups. On the eighth day, the rats were kept for a seven-day consolidation period, and then 60 µg/kg teriparatide (once a day) was administered to group T subcutaneously for seven days. Then, all the rats were sacrificed, and histological sections were stained with hemo-toxylin-eosin for examination. Anti-osteonectin, anti-osteo-calcin, anti-Vascular endothelial growth factor (VEGF) and an-ti-transforming growth factor beta (TGF-?) were evaluated by immunohistochemical analysis in the midpalatal suture area. Results: Histologically, the newly formed bone tissue was observed to be larger in group T than in group C. The number of immunoreactive osteoblasts for osteonectin, osteocalcin and VEGF antibodies was significantly higher in group T than in group C (p = 0.0001). The TGF-? antibody showed a mild reac-tion in group T, but did not reach significance in comparison with group C (p ? 0.05). Conclusion: Systemic teriparatide application following the premaxillary expansion of the suture area may stimulate bone formation and add to the consolidation of the expansion in rats by regulating osteonectin, osteocalcin and VEGF. © 2022, Dental Press International. All rights reserved.Öğe Semirapid Maxillary Expansion and Mandibular Symphyseal Distraction Osteogenesis in Adults: A Five-Year Follow-up Study(2012) Malkoç S.; Işeri H.; Durmuş E.The aim of this study was to evaluate the long-term effects of semirapid maxillary expansion (SRME) and mandibular symphyseal distraction osteogenesis (MSDO) on dentofacial structures in adult patients. The sample comprised posteroanterior cephalograms of 14 patients, with an age range between 15.8 and 25.01 years (mean, 20.09 ± 2.36 years) at the start of treatment. Records were obtained before treatment (T1, day 0), at the end of SRME and MSDO retention (T2, 4.57 ± 0.65 months), at the end of orthodontic treatment (T3, 22.14 ± 4.69 months between the end of SMRE/MSDO retention of SRME/MSDO and end of orthodontic treatment), and after a 5-year follow-up period (T4, 4.99 ± 1.00 years, between the end of orthodontic treatment and follow-up). Data were analyzed statistically by using the repeated measure analysis of variance and paired t test. Statistically significant changes were observed in the lower nasal, bimaxillary, upper molar, upper incisors, lower molar, and lower incisors at the end of the retention period (P < 0.001). The following changes were statistically significantly changed from T1 radiograph to the T4 radiograph: upper and lower nasal widths, nasal angle, bimaxillary width, upper and lower molar width, upper and lower incisor intercrown widths, and upper and lower incisor interapex widths. The following changes were not statistically significantly changed from the T1 to the T4: orbital width, zygomatic width, bicondylar width, bigonial width, biantegonial width, and ramal angle. SRME and MSDO efficiently increased mandibular skeletal and dental arch widths; therefore, it is an efficient nonextraction treatment alternative for patients with maxillomandibular transverse deficiencies. © 2012.
