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    Insulin-like growth factor binding proteins in peritoneal fluid of women with minimal and mild endometriosis
    (Oxford University Press, 1996) Taskin O.; Giudice L.; Mangal R.; Dunn R.C.; Dsupin B.A.; Poindexter A.N.; Wiehle R.D.
    This prospective cohort study was carried out in a university-based infertility clinic to determine the profile of insulin-like growth factor binding proteins (IGFBPs) in patients with mild endometriosis and no obvious mechanical factor contributing to infertility. A total of 26 patients with minimal and mild endometriosis and 10 controls contributed peritoneal fluid at surgery. The variety, expression and levels of IGFBPs were determined by radioimmunoassay and Western ligand blots (WLBs) with quantitation by laser densitometer. A 27 kDa species was significantly lower and a 31 kDa species tended to be lower in patients with endometriosis as determined by quantitative laser densitometer. The levels of IGFBP-3 detected by radioimmunoassay and by WLB were correlated in the control group and in-the patients with endometriosis in the follicular phase but not in patients with endometriosis in the luteal phase. The level of 27 kDa species seen on WLBs did not appear to correspond to IGFBP-1 determined by radioimmunoassay and IGFBP-3 levels in luteal phase endometriosis patients also departed from values determined by radioimmunoassay. These discrepancies suggest a complex system to control levels of IGF in the peritoneum involving multiple binding proteins and proteases. The IGFBPs of patients with endometriosis may contribute to reproductive dysfunction and be able to serve as markers.
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    Prevention and treatment of ovarian cysts with oral contraceptives: A prospective randomized study
    (Mary Ann Liebert Inc., 1996) Taskin O.; Young D.C.; Mangal R.; Aruh I.
    To determine if treatment with low-dose combination oral contraceptives hastened resolution of ovarian cysts or prevented their occurrence, we conducted a prospective randomized study of 45 women with ovarian cysts and 50 women without ovarian cysts and divided the patients into four groups. Group A patients (n = 25) had no cysts and received oral contraceptives, group B patients (n = 25) had no cysts and were expectantly managed, group C patients (n = 25) had cysts and received oral contraceptives, and group D patients (n = 20) had cysts and were observed. All patients were followed with transvaginal ultrasound examinations every 4 weeks for three cycles, with cyst dimensions and ovarian volumes recorded. There were no statistically significant changes in the size of the cysts or ovarian volumes between groups who received oral contraceptives and groups who received expectant management (p > 0.05) Prophylactic treatment with the oral contraceptive did produce a statistically significant reduction in the incidence of ovarian cyst formation. Cyclic low-dose oral contraceptives had no effect on resolution of ovarian cysts but did seem to protect against cyst formation in short-term use.