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Öğe Assessment of change in neutrophil-lymphocyte ratio, platelet-lymphocyteratio in patients with acute and chronic urticaria(2018) Sarac, Gulbahar; Mantar, İrem; Sener, Serpil; Cenk, Hülya; Kapicioglu, YeldaAim: Urticaria is a skin disease characterized by erythematous, oedematous, itchy,and spontaneously disappearing urticaria lesions. One of the most common skin diseases, it is the most common reason underlying the presentations to emergency departments. Our objective is to investigate the role of systemic inflammation in urticaria pathogenesis by measuring the indicators of NeutrophilLymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) in routine hemograms in patients with acute and chronic urticaria. Material and Methods: Of patients visiting the Dermatology Policlinic of İnönü University Medical School Hospital between July 2017 and February 2018, 69 patients diagnosed with acute urticaria and 188 patients diagnosed with chronic urticaria as well as 90 healthy people taken as controls with an age range of 18to 70 were included in our study. Blood values of patients were studied retrospectively. (For the study, a Research Ethics Approval was obtained from Malatya Research Ethics Board.) Results: No significant difference was detected among the study groups in terms of demographic properties. Whereas a significant difference was noted among the three groups with regard to NLR values, no statistically significant difference was detected among the groups with respect to PLR values. No statistically significant difference was observed between the group of patients with urticaria and the control group in terms of erythrocyte distribution(p:0.01). On the other hand, when the patient group with chronic urticaria was divided into two subgroups as patients with a complaint duration of 90 days and less, and those with a complaint duration of more than 90 days and evaluated, no statistically significant difference was detected between these groups in terms of RDW, lymphocytes, neutrophils, platelets, NLR and PLR values Conclusion: In our study, we have determined that systemic inflammation has increased in the group of patients with urticaria as compared to the control group. What’s more interesting in this study is our conclusion that the pathways involved in continued inflammation do not change by time in chronic urticaria.Öğe Autologous mesenteric vein and peritoneum for repair of portal vein and hepatic artery injuries accompanying bile duct injury following laparoscopic cholecystectomy(2018) Kapıcıoğlu, Yelda; Cenk, Hülya; Şener, Serpil; Mantar, İrem; Saraç, GülbaharAbstract: Biliary tract injuries are still the most hazardous complications of laparoscopic cholecystectomy. Concomi-tant vascular injuries make them further more complicated and complex surgical interventions including autologous grafting can be required. We presented a 32-year-old female referred us with combined bile duct, portal vein and hepatic artery injuries occurred during laparascopic surgery. The repairs of hepatic artery and portal vein were achieved by autologous inferior mesenteric vein and peritoneum grafts, respectively. Bile duct reconstruction was done by Roux-en-Y hepaticojejunostomy. Postoperative course was unevent-ful and she was asymptomatic following 16 months follow-up. Autologous vein and peritoneal grafts can be used for repair of vascular injuries of laparascopic cholecystectomy.Öğe Determination of sunscreen and cosmetic product use awareness in adolescents(2019) Sarac, Gulbahar; Kayhan Tetik, Burcu; Sener, Serpil; Mantar, İrem; Kapicioglu, YeldaAim: Using an appropriate sunscreen is very important because the role of sun rays in development of skin cancer is well known. Besides, the recent increase in the use of cosmetics among adolescents is noteworthy. In this study, we aimed to determine the frequency of using cosmetics and the level of awareness of harmful effects of the sun, in adolescents. Material and Methods: In this cross-sectional descriptive study, a questionnaire consisted of 25 questions was applied, on voluntary basis, in middle schools. Results: A total of 607 students participated in the study; 434 participants were female students (71.5%), 173 were male students (28.5%) and the average age was 17 years. The question “Do you think it is necessary to protect from the sun?” is answered as “yes” by 361 of the female students (81.1%) and 109 of the male students (62.3%). The question “Do you use sunscreen?” is answered as “Yes” by 33.3% of all participants. Conclusion: In our study, we found that adolescents had a good understanding of the harmful effects of sun, but in contrast to this, we found that the use of sunscreen products was at very low levels. We think that education and methods for building awareness in this regard will be effective.Öğe Determination of sunscreen and cosmetic product use awareness in adolescents(2019) Saraç, Gülbahar; Tetik, Burcu Kayhan; Şener, Serpil; Mantar, İrem; Kapıcıoğlu, YeldaAbstract: Aim: Using an appropriate sunscreen is very important because the role of sun rays in development of skin cancer is well known. Besides, the recent increase in the use of cosmetics among adolescents is noteworthy. In this study, we aimed to determine the frequency of using cosmetics and the level of awareness of harmful effects of the sun, in adolescents. Material and Methods: In this cross-sectional descriptive study, a questionnaire consisted of 25 questions was applied, on voluntary basis, in middle schools. Results: A total of 607 students participated in the study; 434 participants were female students (71.5%), 173 were male students (28.5%) and the average age was 17 years. The question “Do you think it is necessary to protect from the sun?” is answered as “yes” by 361 of the female students (81.1%) and 109 of the male students (62.3%). The question “Do you use sunscreen?” is answered as “Yes” by 33.3% of all participants. Conclusion: In our study, we found that adolescents had a good understanding of the harmful effects of sun, but in contrast to this, we found that the use of sunscreen products was at very low levels. We think that education and methods for building awareness in this regard will be effective.Öğe Polikaprolakton ve kalsiyum hidroksilapatit etken maddeli dermal dolguların rat derisinde oluşturdukları antiaging etkilerin karşılaştırılması(İnönü Üniversitesi, 2020) Mantar, İrem; Saraç, GülbaharAmaç: Polikaprolakton(PCL) ve Kalsiyum hidroksilapatit(CaHA) son 10 yılda kozmetoloji alanında sık tercih edilen yarı kalıcı cilt dolgularıdır. İçerdikleri mikrosferler sayesinde dermiste neokollajenizasyonu uyarırlar. Bu çalışmanın amacı bu iki dolgunun dermal Tip 1 ve Tip 3 kollajen düzeyini artırmada etkinliklerini rat derisinde karşılaştırmaktır. Materyal ve Metot: 30 dişi rat her grupta 10 hayvan olacak şekilde 3 gruba ayrıldı; kontrol grubu, polikaprolakton ve kalsiyum hidroksilapatit grubu. 2. Ve 4. aylarda alınan doku örnekleri hematoksilen eozin, masson trikrom, tip 1 ve 3 immunhistokimyasal antikorlar ile boyandı. Kollajen yoğunluğu İmage J bilgisayar programı kullanılarak kantitatif olarak karşılaştırıldı. Bulgular: 2 ve 4. Aylarda kollajen yoğunluğu her iki dolgu grubunda kontrol grubuna oranla artmış olarak değerlendirildi. CaHA ve PCL kıyaslandığında kollajen yoğunluğu ya da tip 1 ve tip 3 kollajen H skorları arasında anlamlı bir fark saptanmadı. PCL grubunda 4. ayda fibroblast nükleus sayısı her iki gruba göre anlamlı düzeyde yüksek bulundu. Dermis kalınlığının 4. ayda kontrol grubuna göre her iki dolgu grubunda yükek olduğu saptandı, dolgu grupları arasında anlamlı bir fark yoktu. Sonuç: CaHA ve PCL dolgunun kollajenizasyona etkisini histolojik ve immunhistokimyasal olarak karşılaştırdık. PCL ve CaHA dolguların dermal kollajen yoğunluğunu, tip 1 ve tip 3 kollajen miktarını artırmada ve dermis atrofisini önlemede etkili olduklarını bulduk ve bu açılardan birbirlerine üstünlükleri olmadığını gösterdik. PCL dolgunun CaHA dolguya oranla daha fazla fibroblast artışı sağladığını ve fibroblast proliferasyonunu uyarma etkisinin daha uzun sürdüğünü göstermiş olduk.
