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Öğe Comparison of lateral deltoid splitting and deltopectoral approaches in the treatment of proximal humerus fractures(Turkish Assoc Trauma Emergency Surgery, 2015) Korkmaz, Mehmet Fatih; Erdem, Mehmet Nuri; Karakaplan, Mustafa; Gormeli, Gokay; Selcuk, Engin Burak; Maras, Zeynep; Karatas, TurgayBACKGROUND: Fractures of the proximal humerus that limit function are quite common. The objective of this retrospective study was to compare deltoid splitting and deltopectoral approaches by using the same fixation method. METHODS: Eighty-six patients who underwent surgical treatment between September 2005 and July 2011 were included into the study group. Deltoid splitting approach was used by exploring the axillary nerve on Group A patients as described by Codman, and deltopectoral approach was used on Group B patients. Group A consisted of a total of fifty-six patients of whom twenty-two were male and thirty-four were female patients, with a mean age of 62.5 years (range, 26 to 90 years). Group B consisted of a total of thirty patients of whom fourteen were male and sixteen were female patients, with a mean age of 54.8 years (range, 24 to 84 years). PHILOS plate system was utilized as an internal fixation tool in all patients. Functional results and complications of the two groups were compared using Constant scores. RESULTS: It was observed that humeral head and tubercular fragment reduction were better with lateral deltoid splitting approach, and Constant shoulder scores were higher in the early stages (66.8-57.4 consecutively; p0.05). DISCUSSION: Deltoid splitting approach, especially with AO/ASIF B and C type fractures, enables reduction and plate fixing under 270 degree control of the proximal humerus without forceful retraction and soft tissue damage, providing easy access to posterior tubercular fragment. Compared to deltopectoral approach, patients treated with deltoid splitting approach achieved higher Constant scores at an earlier stage. Lateral deltoid splitting approach, by exploring the axillary nerve, is a useful surgical technique which provides an expansive and multi-dimensional control without risking the deltoid muscle function and the axillary nerve.Öğe Determination of Phytochemical Composition in Fruits and Leaves from Different Origins: Black Mulberry, Chokeberry and Elderberry Genotypes(Taylor & Francis Inc, 2024) Zengin, Rukiye; Maras, Zeynep; Ugur, Yilmaz; Oezhan, Onural; Karaat, Firat Ege; Erdogan, SelimBlack mulberry, chokeberry and elderberry have medicinal properties associated with the presence of phytochemicals which are compounds with potential antioxidant properties. The previously published reports have shown that these compounds significantly affect the course of disease processes by counteracting oxidative stress. In this study, the primary anthocyanins were identified using high-performance liquid chromatography - tandem mass spectrometry (LC-MS/MS). Individual phenolic compounds, tocopherols and amygdalin were quantified by high-performance liquid chromatography with diode-array detection (HPLC-DAD). Elemental contents were determined by inductively coupled plasma - optical emission spectroscopy (ICP-OES). The obtained results reveal the significant presence of primary and secondary compounds in the assessed fruits and leaves, with notable variations depending on fruit species and genotypes. The most abundant compounds were phenolic acids and flavonoids. Analyses indicated that chlorogenic acid, rutin, and cyanidin derivatives were predominant phenolic compounds in all fruit species, while phenolic acids and flavonoids were prominent in leaf samples. The highest chlorogenic acid was determined in black mulberry leaves (ranging from 2403.23 to 3542.53 mg/100 g). Generally, the concentration of phenolic compounds were higher in the leaves than in the fruits of the plant. The highest concentration of amygdalin was detected in black mulberry fruits, ranging from 102.12 to 272.46 mg/100 g. Calcium and potassium were the dominant elements in both berries and leaves.Öğe Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses(Wiley, 2021) Yilmaz, Ismet; Maras, Zeynep; Ozgur, Mustafa Erkan; Durmaz, Murat; Ulusoy, Halil Ibrahim; Erdogan, Selim; Ugur, YilmazMetamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methylamino antipyrine (MAA), an active primary metabolite of MT. The present study aims to determine the pharmacokinetic (PK) profiles of MT metabolites after intravenous (IV) and intramuscular (IM) administration into sex of Arabian horses (Equus ferus caballus) using a cross-over study design. The plasma samples were extracted by solid-phase extraction (SPE) method, and plasma concentrations of MT metabolites were analyzed by high-performance liquid chromatography (HPLC). After administrations of MT, plasma concentrations of methylamino antipyrine (MAA), amino antipyrone (AA), and acetylamino antipyrone (AAA) were determined within range of 15 min-12 h. Plasma concentrations of AA and AAA were lower than the plasma concentrations of major metabolite MAA at each sampling point. The PK parameters were statistically evaluated for MT's metabolites between male and female horses and also between IM and IV administrations of PK parameters such as C-max, t(max), t(1/2 lambda z), AUC(0-t), AUC(0-infinity), lambda z, Cl and V-ss (p < .05). The AUC(IM)/AUC(IV) ratio in female and male horses for MAA was 1.19 and 1.13, respectively. The AUC(IM)/AUC(IV) ratio for AA was lower than those found for MAA. AUC(IM)/AUC(IV) ratio was statistically significantly different between male and female horses for AA (p < .05). According to these results, some PK parameters such as Cmax, AUC, and MRT, MAA and AA concentrations have shown statistically significant differences by MT administrations.Öğe The relationship between semen seminal plasma ions and sperm cell velocnies of wild-caught longspine scraper, Capoeta trutta(Copernicus Gesellschaft Mbh, 2019) Ozgur, Mustafa Erkan; Maras, Zeynep; Erdogan, SelimIn this study, semen seminal plasma contents and the motility of sperm cells were determined in Capoeta trutta via a computer-assisted sperm analysis system. In addition, we evaluated the relationship between semen seminal plasma ions and the velocities of sperm cells. Although the predominant ions were K (206.84 +/- 20.61 mg L-1) and Na (128.06 +/- 23.82 mg L-1) in the semen seminal plasma, Ca (14.05 +/- 4.13 mg L-1) and Mg (3.35 +/- 0.44 mg L-1) were not predominate according to our results. However, partially strong relationships between the curvilinear velocity value (VCL) and K (R-2 = 0.67; p <0.05) were found, while it was moderate with Mg (R-2 = 0.48; p <0.05). There was a weak relationship with Na (R-2 = 0.17; p <0.05) and Ca (R-2 = 0.34; p <0.05). In our results, while the trace metals were determined as Zn > Al > B > Li > Cu in semen seminal plasma, they are not correlated with sperm cell velocities. Finally, we hope that the present information on the motility parameters of Capoeta trutta in this paper will eventually help artificial insemination in reproduction practices.
