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    Electrochemical Bio-Monitoring of the Analgesic Drug Paracetamol, the Antipsychotic Sulpiride, and the Antibiotic Bromhexine Hydrochloride Using Modified Carbon Paste Electrode Based on Ca 0.7 La 0.3 Fe 0.3 Ni 0.7 O 3 Nano-Sized Particles and Black Carbon
    (Elsevier, 2024) Mekersi, Mouna; Ferkhi, Mosbah; Khaled, Ammar; Maouche, Naima; Foudia, Malika; Savan, Ebru Kuyumcu
    Drug biomonitoring using developed modified sensors, especially with recent electrochemical techniques, is considered an essential step and plays a significant role in the good detection of several drugs in biofluids, minimizing the damages resulting from their overdoses. This work is based on the detection of three important drugs such as paracetamol (PCM), sulpiride (Sulp), and bromhexine hydrochloride (Brh-HCl) with different pharmaceutical families. A specific sensor was fabricated called the carbon paste electrode (CPE) based on Ca 0.7 La 0.3 Fe 0.3 Ni 0.7 O 3 (CLFN) nanoparticles (NPs) synthesized by a citrate method and modified with black carbon (BC). A low-cost, highly sensitive BC/CLFN NPs/CPE sensor was prepared for the simultaneous determination of the three drugs using cyclic voltammetry (CV), differential pulse voltammetry (DPV), square wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). Physicochemical characterization was conducted using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The calculated crystallite size using the Debye-Scherer equation was 237.08 nm by XRD, while the nanoparticles grain size was 60.27 nm extracted from SEM surface images. As a result, the developed sensor demonstrates a high response and sensitivity towards PCM, Sulp, and Brh-HCl molecules compared to literature with excellent and low detection limits of 0.36 mu M, 0.042 mu M, and 2.88 mu M for PCM, 0.073 mu M, 0.12 mu M, 15.45 mu M for Sulp, and 0.407 mu M, 0.17 mu M, 7.82 mu M for Brh-HCl drug by CV, DPV and SWV techniques, respectively. High sensitivities of 6588.07, 149.73, and 83.35 mu A. mu M- 1 .cm- 2 for PCM, Sulp, and Brh by CV technique, respectively with wide linear range from 0.01 mu M to 180 mu M for PCM, from 0.1 mu M to 160 mu M for Sulp, and from 0.5 mu M to 240 mu M for Brh by DPV technique. Additionally, the modified CLFN NPs/BC/CPE sensor demonstrated excellent results in real pharmaceutical samples for all three drugs. The reported results include very good recoveries of 104.21 %, 98.68 %, and 95.50 %, and excellent relative standard deviations of 1.18 %, 1.52 %, and 2.84 %, respectively.
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    Electrochemical biodetection of glucose using La0.6Sr0.4Co0.8Fe0.2O3 and La1,7Sr0,3CuO4 NanoParticles modified with black carbon deposited on glassy carbon electrode
    (Elsevier, 2023) Mekersi, Mouna; Ferkhi, Mosbah; Savan, Ebru Kuyumcu
    Non-enzymatic developed biosensors, especially with noble nanoparticles received tremendous attention in the field of glucose molecule sensing. Herein low-cost, highly sensitive, and more effective nano-sized materials such as La1,7Sr0,3CuO4 and La0.6Sr0.4Co0.8Fe0.2O3 were synthesized by a simple citrate method, and modified with black carbon in purpose to use as electrodes for the simultaneous detection of glucose. The crystallite size, refinement, purity, shape, and morphology of nanomaterials were characterized using X-ray diffraction and Scanning Electron Microscopy techniques. Cyclic voltammetry, Differential Potential Voltammetry, Square Wave Voltammetry, and Electrochemical Impedance Spectroscopy techniques were used as investigative techniques. The modified electrodes showed excellent response and sensitivity for glucose molecule detection compared with previous literature, with a wide linear range from 0.1 M to 0.1 nM for La0.6Sr0.4Co0.8Fe0.2O3 and 0.1 M to 0.001 nM for La1,7Sr0,3CuO4, high sensitivities of 614.7 and 876.3 mu A.mM- 1.cm 2 and low detection limits of 0.972 nM and 0.0194 nM respectively. The performance of electrodes was checked by using real samples like synthetic urine and human blood. Both of the modified electrodes demonstrated satisfactory and reproducible results in real samples.
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    Electrochemical simultaneous determination of nitrate ions in water using modified glassy carbon electrode based on La1.7Sr0.3CuO4 and La0.6Sr0.4Co0.8Fe0.2O3 nanomaterials and black carbon sensors
    (Springer Heidelberg, 2024) Mekersi, Mouna; Savan, Ebru Kuyumcu; Ferkhi, Mosbah
    Nanoparticle-based materials have played an important role in the development of new electrochemical sensors and received recently tremendous attention for the detection of toxic ions such as nitrate molecules (NO3- and NO2-). Here, we employ La1.7Sr0.3CuO4 (LSCu) and La0.6Sr0.4Co0.8Fe0.2O3 (LSCF) low-cost, highly sensitive nanoparticles modified with black carbon as sensors for the detection of nitrate ions. The modified nanooxides were synthesized by a simple citrate method then prepared with black carbon powder and nafion solution as a sensing matrix on a glassy carbon electrode for the determination of nitrates ions in water using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy as electrochemical techniques. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used for structural and morphological characterization. The calculated crystallite size d, using the Debye-Scherrer equation was found to be 325,193 nm for LSCu and 208,317 nm for LSCF by XRD technique. The grain sizes are, respectively, 47.80 nm and 65.05 nm which were extracted by SEM analysis. In this work, the modified sensors based on LSCu and LSCF demonstrate satisfactory response and sensitivities toward nitrate molecules compared with previous works. They characterized with very low detection limits of 0.0014 nM and 0.02 nM, high sensitivities of 58.8 and 57.3 mu A.mu M-1, respectively, and recorded a wide linear range from 1 M to 10(-12) M for LSCF and 4 M to 10(-13) M for LSCu. Both of the modified electrodes demonstrated excellent results in real river water sample with low detection limits of 3.1 nM for LSCu and 3.5 nM for LSCF and very good recoveries of 100.6% and 101.65%, respectively.