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    Associations between serum levels of adiponectin and resistin and metabolic parameters in pregnant women with gestational diabetes mellitus
    (Imr Press, 2018) Bagci, H.; Melekoglu, R.; Gursu, M. F.; Akyol, A.; Bulmus, F. G.
    Introduction: Gestational diabetes mellitus (GDM) is defined as a glucose intolerance firstly diagnosed during pregnancy. In this study, the authors aimed to investigate the association between serum adiponectin, and resistin levels with insulin resistance and metabolic parameters in patients with GDM. Material and Methods: A total of 80 patients: 40 healthy pregnant women (control group) and 40 pregnant women diagnosed with GDM (study group) were included in this study. Serum adiponectin, resistin, glucose, insulin, HbA1c levels, and lipid parameters were measured. Insulin resistance index HOMA-IR values were calculated. Results: Serum adiponectin levels were detected to be significantly lower (p < 0.001), whereas serum resistin levels were found to be significantly higher (p = 0.004) in GDM group compared with the control group. Levels of HDL-C, LDL-C, VLDL-C, and triglycerides were similar in both groups, but the total cholesterol level was significantly higher in the GDM group (p = 0.013). In the GDM group, adiponectin levels were negatively correlated with HbA1c levels (r = -0.368; p = 0.010) but were not correlated with any other parameter. A significant positive correlation was evident between resistin levels and both total cholesterol (r = 0.476, p = 0.001), and LDL-cholesterol (r = 0.293; p = 0.033). Conclusion: The results of this study demonstrated that serum resistin levels were significantly higher and serum adiponectin levels were significantly lower in pregnant women with GDM patients compared with normoglycemic pregnants. Also, it was detected that there was no correlation between serum adiponectin and resistin levels and insulin resistance in GDM patients.
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    A CASE OF CONFINED PLACENTAL MOSAICISIVI WITH TRISOMY 15 ASSOCIATED WITH TURNER SYNDROME
    (Medecine Et Hygiene, 2016) Ekici, C.; Sahin, Y.; Yaykasli, K. O.; Melekoglu, R.; Sahin, N.; Yuksel, S.
    A case of confined placental mosaicism with trisomy 15 associated with Turner syndrome: We here present a rare case of a Turner syndrome with mosaic trisomy 15 identified on chorionic villous sampling (CVS). Although there are several reports in the literature indicating confined placental mosaicism (CPM), counseling parents of a fetus with trisomy 15 mosaicism at CVS remains difficult because of the phenotypic variability. To illuminate that condition an amniocentesis or cord blood study should be offered in conjunction with genetic counseling.
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    CTRPs, β3-AR signaling, and placental fibrin deposition: molecular and histopathological aspects of preterm birth
    (Taylor & Francis Ltd, 2026) Askin Ozek, D.; Melekoglu, R.; Akpolat, N.; Yuce, H.; Zeyveli-Celik, N.; Yasar, S.; Berberoglu, Y.
    It has been suggested that adipokines may modulate plasma lipid levels, and beta 3-adrenergic receptor (beta 3-AR) gene expressions may affect adipokine levels and play critical roles in lipid metabolism. This study aims to determine predictive biomarkers for preterm birth (PTB) by evaluating serum complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) levels, lipid profiles, gene expressions, and placental pathological changes in women experiencing PTB. A total of 80 pregnant women, 40 preterm and 40 term, who applied to the Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, were included in the study. Blood and placenta samples were taken from all participants. Serum CTRP, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), and triglyceride (TG) levels were measured; beta 3-AR gene expression and detection rate of the beta 3-AR rs4994 (Trp64Arg) amplicon were evaluated. Placental tissues were examined histopathologically for perivillous/intervillous fibrin deposition and hydropic degeneration. ROC analysis was used to determine predictive biomarkers for PTB. In the PTB group, compared to the control group, beta 3-AR gene expression levels and serum CTRP3 levels were significantly decreased, while the detection rate of the Trp64Arg amplicon and serum CTRP4 levels were significantly increased. In addition, LDL levels increased significantly (p = 0.046), TC levels decreased (p = 0.045). According to ROC analysis, LDL (p = 0.039), TC (p = 0.034), CTRP3 (p = 0.019), and CTRP4 (p = 0.033) levels were determined as significant predictive biomarkers for PTB. Histopathological examination revealed increased perivillous and intervillous fibrin deposition and marked hydropic degeneration in the PTB group. Changes in CTRP levels, lipid profile disorders, and a decrease in beta 3-AR signaling pathways were found to be associated with PTB. LDL, TC, CTRP3, and CTRP4 levels can be evaluated as potential biomarkers that can be used in the early diagnosis and management of PTB.