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Öğe A case of confined placental mosaicism with trisomy 15 associated with turner syndrome(Editions Medecine et Hygiene, 2016) Ekici C.; Sahin Y.; Yaykasli K.O.; Melekoglu R.; Sahin N.; Yuksel S.A cade ofconfined placental mosaicism with trisomy 15 associated with Turner syndrome: We here present a rare case oj'a Turner syndrome with mosaic trisomy 15 identified on chorionic villous sampling (CVS). Although there are several reports in the literature indicating confined placental mosaicism (CPM), counseling parents of a fetus with trisomy 15 mosaicism at CVS remains difficult because of the phenotypic variability. To illuminate that condition amniocentesis' or cord blood study should be offered in conjunction with genetic counseling.Öğe Increased prevalence of chronic medical conditions linked to higher rates of adverse perinatal outcomes in Dutch women(BMJ Publishing Group, 2024) Melekoglu R.[No abstract available]Öğe Prevention of Fertility due to Chemotherapy-Induced Ovarian Failure: Role of Therapeutic Antioxidants(Springer Singapore, 2022) Melekoglu R.; Dogan U.K.; Celik N.Z.; Yilmaz E.Advancements in chemotherapy treatments are leading to increased survival rates for cancer sufferers. Advances in anticancer therapy have contributed to higher survival rates, but ovarian failure that leads to infertility is one of the long-term adverse effects due to primordial follicle loss caused by gonadotoxic chemotherapy. Therefore, prevention of premature ovarian failure and protection of the ovarian follicle pool has gained increasing attention to improve the quality of life of female cancer patients receiving chemotherapy. A non-invasive medical approach (including administration of antioxidant therapy to conventional chemotherapy regimens) to prevent chemotherapy-induced ovarian damage may be preferred, although there are successful invasive fertility preservation options. Most of the chemotherapeutic agents act by producing free radicals that cause cellular damage and necrosis of malignant cells as part of their mode of action in cancer treatment. Despite nearly three decades of research that sought to determine the effectiveness and safety of dietary antioxidant supplementation while undergoing conventional chemotherapy, some controversy remains about efficacy and safety. This claim has been backed up by numerous clinical trials which have demonstrated that certain antioxidants help to restore the body’s natural antioxidants, which are often depleted after chemotherapy treatment, and reduce side effects of cytotoxic agents, including prevention of chemotherapy-induced ovarian failure as well as increase in overall survival of patients receiving chemotherapy. Further randomized controlled clinical researches should be designed to evaluate the use of a specific combination of antioxidants in chemotherapy and determine optimal doses of antioxidants for specific cancer setting to prevent chemotherapy-induced ovarian failure. © Springer Nature Singapore Pte Ltd. 2022.Öğe Successful obstetric and anaesthetic management of a pregnant woman with achondroplasia(BMJ Publishing Group, 2017) Melekoglu R.; Celik E.; Eraslan S.Achondroplasia is the most prevalent form of dwarfism, and there is little evidence about the optimal management of pregnant women with achondroplasia. We presented a 25-year-old primigravid woman with achondroplasia who was followed up during the pregnancy period and performed elective caesarean section with combined spinal-epidural anaesthesia at the 38th week of gestation. Frequent obstetric follow-up visits and invasive prenatal diagnostic tests should be offered during the antenatal period due to the increased risk for obstetric complications, such as premature delivery and fetal anomalies. Prenatal detailed counselling, comprehensive evaluation of the potential risks, obstetric and perioperative management should be performed by a multidisciplinary care team, including an obstetrician, anaesthesiologist, pulmonologist, cardiologist and neonatologist. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved.Öğe Synthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman’s Syndrome) after Surgical Injury(American Chemical Society, 2024) Aksoy Erden B.; Kurus M.; Turkcuoglu I.; Melekoglu R.; Balcioglu S.; Yigitcan B.; Ates B.Asherman’s syndrome, which can occur during the regeneration of damaged uterine tissue after surgical interventions, is a significant health problem in women. This study aimed to acquire and characterize cyclodextrin-based hydrogels, which can be used to prevent Asherman’s syndrome, and investigate their effectiveness with biomedical applications. A series of hydrogels were synthesized from the cross-linking of ?-cyclodextrin and different polyphenols with epoxy-functional PEG. Their chemical, physical, and biological properties were subsequently determined. The results demonstrated that the cyclodextrin-based hydrogels had a porous structure, high swelling ratio, good injectability, drug release ability, and antioxidant activity. Cell culture results illustrated that the hydrogels had no significant cytotoxicity toward L929 fibroblast cells. Considering all properties, the ?-CD-PEG-600-Ec hydrogel showed the most satisfactory properties rather than other ones. The potential of this hydrogel in preventing Asherman’s syndrome was evaluated in a rat model. The results revealed that the ?-estradiol- and melatonin-loaded cyclodextrin-based multifunctional hydrogel group both structurally and mechanically showed an antiadhesion effect in the uterus and a therapeutic effect on the damage with the ?-estradiol and melatonin that it contains compared to the Asherman (ASH) group. This double drug-loaded hydrogel can be a promising candidate for preventing Asherman’s syndrome due to its versatile properties. © 2024 The Authors. Published by American Chemical Society.
