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    A clinical pharmacist's intervention on interaction between meropenem and valproic acid in paediatric inpatient clinic: A case report
    (Istanbul Univ, Fac Pharmacy, 2023) Cakir, Ahmet; Memis, Hasan; Ozdemir, Nesligul; Gun, Zeynep Ulku
    Background and Aims: Drug-drug interactions cause many complex drug events, especially adverse drug effects. It is known that drug interactions occur when meropenem and valproic acid are used together. It was aimed to back up existing research on the interaction of valproic acid. Methods: After an interaction had been suspected by the ward pharmacists, all of the patient's drugs were assessed via UpToDate (R) and Micromedex (R) databases and the interaction management was shared with the physician in charge. Results: The patient's serum valproic acid through level was in therapeutic range before meropenem administration. After the administration of meropenem, the patient's number of seizures increased and the serum trough level of valproic acid decreased to 4.3 mu g/ml. The valproic acid levels turned back to normal range after switching to a carbapenem antibiotic. Conclusion: Drug interactions are often encountered in paediatric patients and it is of critical importance in terms of seizure control. Because of the drug interaction between valproic acid and meropenem, one should avoid using these medications concomitantly. If that is impossible, daily serum valproic acid levels should be monitored with caution. Clinical pharmacists could increase the clinicians' awareness about drug-drug interactions.
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    Is sitagliptin effective for the treatment of COVID-19?
    (Bmj Publishing Group, 2022) Memis, Hasan; Cakir, Ahmet; Durmus, Mefkure; Gok, Selim; Bahcecioglu, Omer Faruk
    [Abstract Not Available]
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    Öğe
    Therapeutic drug monitoring of vancomycin in the case of augmented renal clearance: a case report of a paediatric patient
    (Bmj Publishing Group, 2024) Memis, Hasan; Cakir, Ahmet; Ulgey, Ayse
    Augmented renal clearance (ARC) is a condition in which renal circulation increases, causing drug levels in the blood to remain at subtherapeutic levels in severe trauma patients. Vancomycin, a hydrophilic anti-Gram-positive drug, has been shown in the literature to have its levels fall below the therapeutic range in the case of ARC. However, vancomycin dosing recommendations in the case of ARC are still lacking. Here, we identify an ARC case measured with urinary creatinine clearance in a severe trauma paediatric patient, causing vancomycin blood trough levels to drop. We could not be able to increase the vancomycin trough levels with intermittent dosing; hence, we administered vancomycin with continuous infusion, and this resulted in vancomycin blood trough levels remaining in the therapeutic range. No adverse effect was seen. Continuous infusion of vancomycin can be safely administered to paediatric patients in these cases.