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    Conventional and microwave prompted synthesis, antioxidant, anticholinesterase activity screening and molecular docking studies of new quinolone-triazole hybrids
    (Academic Press Inc Elsevier Science, 2018) Mermer, Arif; Demirbas, Neslihan; Sirin, Yakup; Uslu, Harun; Ozdemir, Zeynep; Demirbas, Ahmet
    The synthesis of ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylates (4, 5) was performed via the reaction of corresponding anilines with diethyl ethoxymethylenemalonate under conventional and also microwave promoted conditions. The treatment of 4 and 5 afforded the corresponding hydrazides (6 and 7). These hydrazides were converted to the corresponding carbo(thio) amides (9a-f and 10a-e) which were then subjected to an intramolecular cyclisation leading to the formation of quinolone-triazole hybrids (11a-f and 12a-e). The newly synthesized compounds were screened for their biological activities such as antioxidant capacity (AC) and acetylcholinesterase Activity. Inhibition of cholinesterases is an effective method to curb Alzheimer's disease, a progressive and fatal neurological disorder. A series of some novel quinolone derivatives were designed, synthesized, and their inhibitory effects on AChE were evaluated. We obtained our compounds and determined their anticholinesterase activities according to the Ellman's method. 9b and 10c showed the best AChE inhibition with 0.48 +/- 0.02 and 0.52 +/- 0.07, respectively. Docking studies were performed for the most active compounds (9b, 10c) and interaction modes with enzyme active sites were determined. As a result of these studies, a strong interaction between these compounds and the active sites of AChE enzyme was revealed. (C) 2018 Elsevier Inc. All rights reserved.
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    Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies
    (Elsevier Science Bv, 2019) Mermer, Arif; Demirbas, Neslihan; Uslu, Harun; Demirbas, Ahmet; Ceylan, Sule; Sirin, Yakup
    Schiff base derivatives were synthesized in this study via conventional, microwave irradiation and ultrasound sonication methods. Optimization conditions were examined for several parameter such as solvent, reaction time and yield. After determining the optimization conditions, the compounds were synthesized by using ultrasound sonication. The structures of the synthesized compounds were examined by spectral data, and the antiurease, antioxidant and antimicrobial activities of the Schiff bases derivatives were investigated due to the imine group (-C=N-) and promising results were obtained. The enzyme inhibitory potentials of these compounds were further validated through molecular docking studies. Also, In Silico ADME prediction studies were calculated for compounds. (C) 2019 Elsevier B.V. All rights reserved.