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Öğe Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects(Springernature, 2024) Akman, Tugrul Cagri; Yazici, Mustafa; Atila, Alptug; Mertoglu, CumaIsotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma-Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, and zinc in plasma increased statistically, while the level of potassium decreased (p < 0.05). The treatment had differing effects on zinc levels based on the gender of the individuals. With treatment, the levels of zinc in the plasma of men showed a greater increase compared to women (p = 7.3e-04). Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between magnesium and calcium. According to the study results, the change in phosphorus and potassium levels shows that isotretinoin affects kidney functions. The results suggest that phosphorus, potassium, magnesium, and zinc are associated with fatigue, dry skin and chapped lips, hair loss, and sebum secretion, respectively. Consequently, the study emphasizes the need for a comprehensive pre-treatment assessment, including monitoring of liver and kidney function as well as the levels of phosphorus and potassium in patients.Öğe Comparison of traditional and novel obesity-related indices for identification of metabolic syndrome in adults(Cukurova Univ, Fac Medicine, 2022) Yilmaz, Sevil Karahan; Ozcicek, Fatih; Mertoglu, CumaPurpose: The aim of this study was to evaluate the traditional and novel obesity-related indices in the determination of metabolic syndrome in adults and to determine which marker is the better predictor. Materials and Methods: A total of 419 adults between the ages of 18-65 were included in this study. Body weight, height, waist, hip and waist circumference, and blood pressure were measured; fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol values were analyzed. Metabolic syndrome (MetS) was defined using the International Diabetes Federation criteria. The values of 23 obesity-related indices were calculated. Results: The prevalence of metabolic syndrome is 58.7% (male 41.2%; female 67.7%). The triglyceride glucose (TyG) index has the largest area under the curve (AUC) in both men (AUC = 0.894, cutoff = 3.9) and women (AUC = 0.901, cutoff = 3.9). In men, lipid accumulation product (LAP) had the second highest determination for MetS (AUC = 0.880, cut-off = 51.1), followed by TyG-waist/hip (AUC = 0.876, cut-off = 3.7). Cardiometabolic index (CMI) (AUC = 0.872, cut-off value = 1.3) and visceral adiposity index VAI (AUC = 0.868, cut-off value = 4.1) had the second and third largest AUCs, respectively, in women. Conclusion: TyG index is the best predictor of MetS. Waist circumference could be an alternative index in large epidemiology survey due to its convenient and cost-efective characteristics.Öğe COVID-19 is more dangerous for older people and its severity is increasing: a case-control study(Wolters Kluwer Medknow Publications, 2022) Mertoglu, Cuma; Huyut, Mehmet Tahir; Olmez, Hasan; Tosun, Mustafa; Kantarci, Mecit; Coban, Taha AbdulkadirCoronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.Öğe Evaluation of the effect of 9.5/11.5-fr ureteral access sheath use on acute kidney injury with the myo-inositol oxygenase biomarker in patients undergoing retrograde intrarenal surgery: a prospective, randomized, and controlled study(Taylor & Francis Ltd, 2024) Turan, Abdullah; Hirik, Erkan; Erdogan, Abdullah; Altun, Abdulsemet; Mertoglu, Cuma; Sam, Emre; Atar, MuhittinIntroductionWe aimed to investigate whether a low intrarenal pressure provided by ureteral access sheath (UAS) use had a positive effect on the prevention of acute kidney injury through the evaluation of the myo-inositol oxygenase (MIOX).Material and methodsThe patients were divided into two groups according to whether a 9.5/11.5-Fr UAS was used during retrograde intrarenal surgery (RIRS): UAS group and non-UAS group. RIRS was performed under gravity irrigation and manual pumping was not used. For the measurement of MIOX, 5 cc blood samples were taken from the patients preoperatively and four hours postoperatively.ResultsOperation time and hospital stay were significantly longer in the UAS group. The mean preoperative and postoperative MIOX values were 0.77 +/- 0.36 ng/ml and 0.74 +/- 0.38 ng/ml, respectively, in the UAS group, and 0.74 +/- 0.31 ng/ml and 0.83 +/- 0.40 ng/ml, respectively, in the non-UAS group. The mean MIOX change was -0.29 +/- 0.36 in the UAS group and 0.08 +/- 0.44 in the non-UAS group, indicating no significant difference between the groups.ConclusionEven if UAS is not used, significant acute kidney injury is not observed under gravity irrigation and therefore, if we avoid manual pumping, the intrarenal pressure remains low, thus potentially rendering the use of 9,5/11,5-Fr UAS unnecessary.Öğe Examining of some physical and physiological parameters of 10-18 years old male skiers to seasonal cycles(Romanian Assoc Balneology, 2022) Budak, Cemalettin; Dundar, Sibel Tetik; Mertoglu, CumaSkiing can be identified as a branch with the most important representative power of winter sports. Further, it has been characterized by high popularity and population, branching off in itself. During the year, different physical performance and physiological indicators are sometimes encountered in athletes depending on seasonal cycles, training levels, and living conditions. The aim of this study is to examine some physical performance parameters and the determined hormone levels to seasonal cycles. Methods: 15 male skiers with a mean age of 14.53 +/- 2.61 (years), a mean height of 158.53 +/- 9.66 (cm), and a mean body mass of 54.20 +/- 10.85 (kg) participated in the study. The information about participants' age, height, and body mass was determined by standard methods. Various measurement tools were used including a digital hand dynamometer (TKK 5401) for hand grip strength, a digital dynamometer (TKK 5402) for back and leg strength, a jump meter (Takei TKK 5406) for vertical jump height, and an electronic hand spirometer (firstMED) for respiratory functions. The Wingate anaerobic power test (Monark 894 E bicycle ergometer) was performed to determine the anaerobic power level. Additionally, to determine somatotypes (ectomorph, mesomorph, endomorph) and body fat percentage; skinfold caliper (Holtain), tape measure, and digital caliper (Holtain) were respectively utilized for skinfold thickness measurement, circumference measurements, and diameter measurements. Blood samples (hemogram test, vitamin D, cortisol, and testosterone to be checked) were taken from the antecubital vein in the sitting position. From the blood samples, serum plasma was separated and preserved by centrifugation (+4o) and all samples were analyzed at once. All tests were performed once in September, December, March, and June at an altitude of 2,000 and in pre-season and mid-season. The data were analyzed through IBM SPSS 24.0 package program. Shapiro-Wilk was used to determine the distribution of the data, descriptive and frequency analysis was used to determine the mean of the variables, and one-way analysis of variance (ANOVA) was used to determine the differences between measurements. The results were presented as arithmetic mean and standard deviation ((X) over bar +/- Ss). Results: In 10-18 years old male skiers, it was determined that vitamin D reached its highest level in autumn, testosterone in summer, and cortisol in winter. In the inter-test comparison results, significant differences were determined in the vertical jump, right and left-hand grip strength, leg strength, testosterone, vitamin D, HCT, FVC, FEV1, and anaerobic power parameters. Conclusions: The results of the study have mostly supported the literature.Öğe Glucose metabolism and oncogenes in cancer(2021) Mertoglu, CumaAbstract: Cancer cells utilize glucose quite differently from regular cells as cancer cells metabolize glucose more in aerobic glycolysis rather than in oxidative phosphorylation. Whereas aerobic glycolysis is less effective in the metabolism than oxidative phosphorylation. This review aims to explain the mechanisms of cancer metabolism and recent findings related to the subject. There are excessive glycolysis and glucose transport in tumor cells, this situation as known Warburg effect. Mitochondrial impairment, hypoxia, oncogenic signals, and defected metabolic enzymes are mechanisms of this cancer metabolism. Results of increased glycolysis are quick production of ATP and intermediates for biosynthetic pathways and occur acidic cell environment. The oncogenes, hypoxiainducible factor (HIF), serine/threonine kinase Akt, K-ras, c-myc, AMP-activated protein kinase (AMPK) and p53 have important roles in cancer metabolism. HIF, Akt, K-ras, c-myc, AMPK, and p53 are important oncogenes in cancer metabolism. The differences in metabolism of cancer cells are important targets for new treatment methods.Öğe Glucose metabolism and oncogenes in cancer(2021) Mertoglu, CumaCancer cells utilize glucose quite differently from regular cells as cancer cells metabolize glucose more in aerobic glycolysis rather than in oxidative phosphorylation. Whereas aerobic glycolysis is less effective in the metabolism than oxidative phosphorylation. This review aims to explain the mechanisms of cancer metabolism and recent findings related to the subject. There are excessive glycolysis and glucose transport in tumor cells, this situation as known Warburg effect. Mitochondrial impairment, hypoxia, oncogenic signals, and defected metabolic enzymes are mechanisms of this cancer metabolism. Results of increased glycolysis are quick production of ATP and intermediates for biosynthetic pathways and occur acidic cell environment. The oncogenes, hypoxia-inducible factor (HIF), serine/threonine kinase Akt, K-ras, c-myc, AMP-activated protein kinase (AMPK) and p53 have important roles in cancer metabolism. HIF, Akt, K-ras, c-myc, AMPK, and p53 are important oncogenes in cancer metabolism. The differences in metabolism of cancer cells are important targets for new treatment methods.Öğe How to prevent unnecessary request prostate-specific antigen testing?(2019) Mertoglu, Cuma; Bozkurt, AliseydiAim: In this study, it was aimed to show how to limit the unnecessary requests of free prostate-specific antigen (fPSA) test changes with some regulations. Material and Methods: The fPSA requirements when total PSA values below 4 ng/mL or above 10 ng/mL were considered ‘unnecessary test request’. To do this, the relevant physicians were informed and the fPSA test was arranged to have a separate second window on the request panel and physicians were requested only tPSA test requests. An additional fPSA test was conducted by the laboratory staff from patients with a tPSA score of 4-10 ng / mL. Results: It was seen that 1236 fPSA and 1292 tPSA tests (fPSA/tPSA = 95.6%) were performed in our research hospital laboratory between January 17,.2017 and March 09,2017 while 328 fPSA and 1139 tPSA tests were also done between January 17, 2018 and March 09, 2018 (fPSA / tPSA = 28.7%). The ratio of sPSA test request to tPSA test request was found to be reduced by 66.9%. Conclusion: This study limited significant hospital expenditure and labor loss reducing the number of unnecessary fPSA tests with regulations made at the test prompt.Öğe Is there a role of antisperm antibodies in women with unexplained infertility - a Turkish pilot cross sectional case control study(2021) Ata, Nahit; Turkler, Can; Ulug, Pasa; Mertoglu, CumaAim: Although some studies indicate that the presence of antisperm antibody (ASA) is important in the etiology of female infertility, this remains a controversial issue. The aim of this study was to determine whether the presence of ASA was important or not in primary and secondary unexplained infertility patients. Materials and Methods: Female patients (n = 90) were divided into three groups as follows: the primary infertility group (n = 30), the secondary infertility group (n = 28) and a control group (n = 32). In addition to laparoscopic evaluations, the presence of ASA in the study groups was also examined in serum and peritoneal washing liquid. The ASA - immunoglobulin G was measured using the Enzyme-Linked ImmunoSorbent Assay (ELISA) method with a qualitative measurement kit. Results: When the demographic data were analyzed, it was observed that the study groups were homogeneous in terms of age and period of infertility. The results of the study demonstrated that, when compared to the secondary infertility and control groups, the ASA positivity in the serum in the primary infertility group was significant (p < 0.05). However, when the groups were compared, there was no difference in terms of ASA positivity in peritoneal washing fluid (p > 0.05). Conclusion: This study showed that the presence of ASA in serum may be an impact on the etiology of unexplained primary infertility.Öğe Oxyhemoglobin Dissociation Curve in COVID-19 Patients(Galenos Publ House, 2023) Ustundag, Hilal; Mertoglu, Cuma; Huyut, Mehmet TahirObjective: Coronavirus disease-2019 (COVID-19) is a disease that can progress with hypoxemia and severe respiratory distress in some patients. The oxyhemoglobin dissociation curve (ODC) is critical to understanding the effects of O2 exchange. This study aimed to evaluate the relationship between the ODC and oxygen-carrying capacity of hemoglobin (Hb) in COVID-19 patients.Materials and Methods: In the study, ODCs were created by examining the data obtained from the arterial blood gas analyses of 686 intensive care unit (ICU) and non-ICU COVID-19 patients retrospectively.Results: It was concluded that patients with COVID-19 and other respiratory distress patients had a slight right-leaning trend in the ODC compared with the standard curve. The P50 value of the ICU group was higher than the other groups (mean: 30.74 mmHg, n=131, p=0.047). While the percentage of oxyhemoglobin (mean: 65.44% vs 69.81%, p=0.015), the amount of glucose (mean: 163.39 mg/dL vs 195.36 mg/dL, p=0.002) and pH (median: 7.38 vs 7.41, p=0.007) in the non-ICU group was higher compared with the control group, the carboxyhemoglobin percentage (mean: 1.66% vs 1.13%, p=0.000), PCO2 (42.02 mmHg vs 39.44 mmHg, p=0.015), potassium (mean: 4.33 mmol/L vs 4.04, p=0.026), and sodium (mean: 138.10 mmol/L vs 135.80 mmol/L, p=0.000) were lower. The methemoglobin percentage of the ICU group was lower (p=0.000) than the other groups.Conclusion: The ODC of COVID-19 and other respiratory distress patients shifts slightly to the right, indicating that patients have partial respiratory difficulties.Öğe The relationship between serum adropin levels and erectile dysfunction(Mre Press, 2024) Keskin, Ercument; Ekici, Ozgur; Erdogan, Abdullah; Bozkurt, Aliseydi; Sambel, Murat; Karabakan, Mehmet; Mertoglu, CumaErectile dysfunction (ED) is associated with endothelial damage, especially atherosclerosis. The search for biomarkers that can predict ED still continues. Adropin is known to affect nitric oxide (NO) bioavailability and energy homeostasis. In our study, we have aimed to investigate the relationship between serum adropin levels and ED. Male patients with and without ED between 40-60 years of age, who presented to the outpatient clinics of urology between November 2019-February 2020, were prospectively included in the study. Biochemical values measured at the time of admission to the outpatient clinic. According to the International Index of Erectile Function -5 (IIEF-5) scores which range between 5 and 25 points, patients with a score <= 21 were considered to have ED. The patients were divided into two groups: as ED and non -ED control groups. Laboratory values obtained at admission to outpatient clinics of urology were compared between groups. Patients with (n: 40), and without (n: 40) ED were included in the study. The mean age (50.2 +/- 5.7 years), average body mass index (BMI) (29.7 +/- 2.5 kg/m(2)), IIEF score (15.8 +/- 6 pts), serum adropin (584.8 +/- 172 pg/mL), and total testosterone (396.4 +/- 91.7 ng/dL) levels were recorded. Serum adropin and testosterone levels were statistically significantly higher in the non -ED group than in the ED group (712.3 +/- 222 pg/mL vs. 511.1 +/- 145 pg/mL, p < 0.001 and 420.5 +/- 56 ng/dL vs. 374.3 +/- 98 ng/dL, respectively p = 0.032). Whereas fasting blood glucose (FBG) values were found to be statistically significantly higher in the ED group (100.2 +/- 14 mg/dL vs. 143.8 +/- 78 mg/dL, p = 0.001). According to the results of our study, serum levels of adropin which improves endothelial functions were comparatively lower in ED patients, as expected.Öğe The Relationship Between Vitamin-D Deficiency and Protein Oxidation Among Obese Children(Taylor & Francis Inc, 2023) Surucu Kara, Ilknur; Mertoglu, Cuma; Siranli, Guelsah; Arslan, Yusuf Kemal; Gok, Gamze; Erel, OzcanAim: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Methods: Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. Results: A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D levels of obese children were lower than those of pre-obese and normal weight (p < 0.05). In the normal weight group, total thiol and native thiol were lower in the pubertal period than in adolescence; were higher in those with sufficient Vitamin-D level than those with insufficient and deficient Vitamin-D (p < 0.05). Vitamin-D level was lower in pre-obese girls than boys (p < 0.05). Those with high triglycerides had high disulfide/total thiol, disulfide, and disulfide/native thiol and low native thiol/total thiol (p < 0.05). Conclusion: Thiol-disulfide homeostasis is negatively affected by low vitamin D levels, pubertal period and high triglyceride levels.Öğe The role of protein oxidation in the development of diabetic microvascular complications(Kare Publ, 2021) Mertoglu, Cuma; Siranli, Gulsah; Coban, T. Abdulkadir; Karakurt, Yucel; Ersoy, Alevtina; Ozcicek, Adalet; Arslan, YusufOBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.Öğe What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?(Elsevier, 2022) Huyut, Mehmet Tahir; Huyut, Zubeyir; Ilkbahar, Fatih; Mertoglu, CumaIt remains important to investigate the changing and impact of routine blood values (RBVs) in order to predict mortality and follow an appropriate treatment in COVID-19 patients. In the study, the importance of RBVs in the mortality of patients with COVID-19 was investigated. The changes in the biochemical, hematological, and immunological parameters of patients who recovered (n = 4364) and died (n = 233) from COVID-19 over time and their relationship with the mortality of the disease were evaluated retrospectively. Odds ratios of the parameters affecting one-month mortality were calculated by running multiple-logistic-regression analysis. The cut off values and diagnostic efficiencies of the parameters that posed a risk for mortality were obtained via receiver operating curve analysis. It was determined that the C-reactive protein (CRP), D-dimer, procalcitonin, erythrocyte-sedimentation-rate (ESR), troponin values were at abnormal levels until death occurred in the patients who died. In addition, the procalcitonin levels were consistently high in patients who died. The patients who died generally had a sustained increase in their leukocyte and neutrophil levels and biochemical variables, and an ongoing decrease in lymphopenia and eosinopenia levels. Although significant changes were observed in liver function tests, cardiac troponin, hemogram values, kidney function tests and parameters related to inflammation in deceased patients, high ESR, international-normalized-ratio (INR), prothrombin-time (PT), CRP, D-dimer, ferritin and red-cell-distribution width (RDW) values, respectively, were the most effective predictive mortality risk biomarkers of COVID-19. In addition, neutrophilia, leukocytosis, thrombocytopenia, erythrocytopenia were other risk predictors of mortality. Indicators was found in this study can be successfully used to predict mortality from COVID-19.Öğe What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality? (vol 105, 108542, 2022)(Elsevier, 2023) Huyut, Mehmet Tahir; Huyut, Zubeyir; Ilkbahar, Fatih; Mertoglu, Cuma[Abstract Not Available]
