Yazar "Meydanli, MM" seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Elevated nucleated red blood cell count(Sci Printers & Publ Inc, 2006) Üstün, Y; Engin-Üstün, Y; Kaya, E; Meydanli, MM; Kulak, NOBJECTIVE: To assess the prevalence and causes of elevated nucleated red blood cell (NRBC) count. STUDY DESIGN: We conducted a 1-year, population based surveillance study that included pregnant women and their infants from our medical center, which serves as a tertiary referral hospital. Outcome measures included NRBC count, gestational age, mode of delivery, birth weight, Apgar scores, cord blood gasses, rate of neonatal intensive care unit admission. Statistical analyses were performed with Mann-Whitney U-test, independent samples t test, chi(2) test, Fisher's exact test and Spearman's correlation test, as appropriate. RESULTS: NRBC count obtained from 423 women had a median of 4 (0-163). A cutoff point of 13.5 for predicting fetal acidosis had the highest combined sensitivity (77.8%) and specificity (84%). Three hundred forty-nine neonates had a NRBC count <= 13.5, whereas 73 had > 13.5. Logistic regression analysis revealed that preeclampsia (OR = 5.9, 95% CI = 2.8-12.3) remained the most prominent risk factor for elevated NRBC count. CONCLUSION: Elevated NRBC appears to be associated with preeclampsia.Öğe Epithelioid trophoblastic tumor of the endocervix: A case report(Academic Press Inc Elsevier Science, 2002) Meydanli, MM; Kucukali, T; Usubutun, A; Ataoglu, O; Kafkasli, ABackground. It is difficult to recognize epithelioid trophoblastic tumor (ETT) as a trophoblastic disease because of its rarity and growth pattern simulating a carcinoma. Case report. A 36-year-old woman with stage IB1 squamous cell carcinoma of the uterine cervix and a high serum beta-human chorionic gonadotropin (beta-hCG) level underwent radical hysterectomy with pelvic and para-aortic lymphadenectomy. However, light microscopic findings and immunohistochemical studies with pan-cytokeratin, epithelial membrane antigen, inhibin-alpha, beta-hCG, and human placental lactogen revealed ETT of the endocervix. The patient is alive with no evidence of disease 12 months after surgery. Conclusion. Before the patient is resorted to radical surgical interventions for assumed cervical carcinoma, ETT should be ruled out in women of reproductive age with endocervical tumors and elevated serum beta-hCG levels. (C) 2002 Elsevier Science (USA).Öğe Labor induction post-term with 25 micrograms vs. 50 micrograms of intravaginal misoprostol(Elsevier Sci Ireland Ltd, 2003) Meydanli, MM; Çaliskan, D; Burak, F; Narin, MA; Atmaca, RObjectives: To compare the effectiveness of 25 mug vs. 50 mug of intravaginal misoprostol for cervical ripening and labor induction beyond 41 weeks' gestation. Methods: The study population consisted of 120 women not in active labor with a gestational age > 41 weeks, singleton pregnancy with vertex presentation, reactive fetal heart rate tracing, amniotic fluid index greater than or equal to 5, and Bishop score < 5. Women were randomized to receive either 25 mug (n = 60) or 50 mug (n = 60) of intravaginal misoprostol. The dose was repeated every 4 h (maximum number of doses limited to six) until the patient exhibited three contractions in 10 min. The main outcome measure was the induction-vaginal delivery interval. Results: There was no significant difference between the two groups with regard to the induction-vaginal delivery interval (685 +/- 201 min in the 25 mug group vs. 627 +/- 177 min in the 50 mug group, P = 0.09). The proportion of women delivering vaginally with one dose of vaginal misoprostol was significantly greater in the 50 mug group (0/49 vs. 41/47, P <0.001). There were no differences in the rates of cesarean and operative vaginal delivery rates, or in the incidences of tachysystole and hyperstimulation syndrome in the two treatment groups. Neonatal outcomes were also similar. Conclusions: Intravaginal administration of 25 mug of misoprostol appears to be as effective as 50 mug for cervical ripening and labor induction beyond 41 weeks' gestation. (C) 2003 International Federation of Gynecology and Obstetrics. Published by Elsevier Science Ireland Ltd. All rights reserved.Öğe Magnetic resonance spectroscopy of premalignant and malignant endometrial disorders: a feasibility of in vivo study(Elsevier, 2005) Celik, O; Hascalik, S; Sarac, K; Meydanli, MM; Alkan, A; Mizrak, BObjective: To assess the potential clinical utility of in vivo proton magnetic resonance spectroscopy (MRS) in patients with various endometrial lesions. Methods: Twelve patients with untreated uterine bleeding were included in this study. In-vivo proton MRS was performed using a 1.5 T MR scanner. The metabolite levels were classified into three classes in comparison with the noise level by visual examination. All the patients have endometrial biopsy. For each type of lesions, chemical compound were described. Results: Pathological examination resulted in three endometrial cancer, two simple hyperplasias, one complex hyperplasia, two partial hydatiform mole, two proliferative endometrium and two secretory endometrium. In women with endometrial carcinoma, high choline and lipid signals were detected, whereas no creatine and no lactate signals were found. In women with endometrial hyperplasia, choline signal was detectable in all cases but one case showed lactate signal in addition to choline. In women with partial hydatidiform mole, the only detectable signal was choline. Lipid signals were detected in none of the cases with endometrial hyperplasia and partial hidatidiform mole. In women with either secretory or proliferative endometrium, choline and lactate signals were detectable in all cases but one case showed solely choline. Lipid signals were not deteced in any of subjects with secretory or proliferative endometrium. Conclusion: The observed difference is the presence of lipid signal only in endometrial carcinoma. (C) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Metabolic changes in pelvic lesions: Findings at proton MR spectroscopic imaging(Karger, 2005) Hascalik, S; Celik, O; Sarac, K; Meydanli, MM; Alkan, A; Mizrak, BObjective: The purpose of this study is to investigate the in vivo magnetic resonance spectroscopic (MRS) features of pelvic lesions using long echo time and to characterize the spectral patterns of various pathological entities. Materials and Methods: 17 patients with surgically and histopathologically confirmed pelvic lesions underwent long echo-time MRS, and the results obtained were analyzed. Before laparotomy, choline (Cho), lactate, lipid and creatine (Cr) levels of all lesions were measured by single voxel MRS ( point-resolved spectroscopy technique, TE 136 ms). Voxels were placed in the center of the lesions. The MRS results of lesions were compared with the final histopathological diagnoses. Results: Spectroscopy analysis of serous, mucinous and undifferentiated carcinoma of the ovary revealed Cho, lactate and lipid signals, but granulosa-theca cell tumor showed only a lipid signal. The Cho signal was obtained from only 3 patients with mature cystic teratoma but none of the other benign ovarian tumors and pelvic abscesses. A lipid signal was detected in 3 patients diagnosed with pelvic abscess and all benign ovarian tumors. In addition to the lipid signal, a lactate signal was detected in the spectra of two pelvic abscesses. One case of endometrioma and 1 case of teratoma did not show any signal. Conclusion: MRS demonstrates significant differences in metabolite concentration between benign and malignant ovarian tumors and pelvic abscesses. MRS may therefore be helpful in the differential diagnosis of adnexal lesions. Copyright (C) 2005 S. Karger AG, Basel.Öğe Pelvic organ prolapse complicating third trimester pregnancy -: A case report(Karger, 2006) Meydanli, MM; Üstün, Y; Yalcin, OTThe concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman, gravida 6, parity 5, was admitted to the hospital with uterine contractions in week 35 of gestation. Pelvic examination in the dorsal lithotomy position revealed a stage 3 pelvic organ prolapse. A cesarean hysterectomy was performed. After hysterectomy, the vaginal cuff was suspended to the periosteum overlying the sacral promontory. Cesarean hysterectomy might be a therapeutic option for women who have completed their families and are suffering from severe pelvic organ prolapse complicating third trimester pregnancy, particularly in developing countries where access to health care is limited. Copyright (C) 2006 S. Karger AG, Basel.Öğe Prediction of adverse outcome associated with vaginal misoprostol for labor induction(Elsevier Science Bv, 2003) Meydanli, MM; Caliskan, E; Haberal, AObjective: To identify predictors of adverse outcome in pregnant women at term receiving 50 mug of intravaginal misoprostol for labor induction. Study design: A prospective observational study was conducted of 720 pregnant women at term with an unfavorable cervix and a medical or obstetric indication for labor induction. All patients received 50 mug of intravaginal misoprostol every 4 h up to three doses. The primary outcome measure was adverse outcome defined as: neonatal death, fetal acidemia and emergent cesarean delivery performed for non-reassuring fetal heart rate tracings. A stepwise logistic regression analysis was used to identify predictors of adverse outcome. Results: Tachysystole (frequent uterine contractions) (odds ratio (OR), 3.7; 95% confidence interval (CI), 1.2-10.8) and fetal tachycardia (OR, 4.8; 95% CI, 1.4-16.2) were determined as significant predictors of adverse outcome. The specificity of the model was 94.2%, whereas the sensitivity was 20.4%. Conclusion: In the absence of tachysystole and fetal tachycardia, an uneventful delivery might be expected for women receiving 50 mug of intravaginal misoprostol. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.Öğe Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis(Pensiero Scientifico Editor, 2003) Meydanli, MM; Erguvan, R; Altinok, MT; Ataoglu, O; Kafkasli, ASmall cell carcinomas are well-recognized tumors known to occur predominantly in the lung. These neoplasms are occasionally associated with a variety of paraneoplastic syndromes. Four cases of paraneoplastic glomerulopathy associated with small cell lung carcinoma have been reported. However, there have been no reports in the literature indicating an association between endometrial small cell carcinoma and paraneoplastic glomerulopathy. We report a case of neuroendocrine small cell carcinoma of the endometrium associated with membranous glomerulonephritis (MGN), which appeared to be a component of an unusual paraneoplastic syndrome. A 33-year-old multiparous woman presented with abnormal vaginal bleeding and abdominal bloating. Endometrial biopsy revealed neuroendocrine small-cell carcinoma of the endometrium. On the eighth day of hospitalization the patient suddenly developed renal failure. Renal biopsy revealed MGN, probably due to tumor-antigen-related immune complex deposition. Small cell carcinoma of the endometrium may be associated with paraneoplastic MGN. Medical staff should take into account the possibility of a preexisting glomerular injury when managing a patient with small cell carcinoma of the endometrium.Öğe Uterine metastasis from infiltrating ductal carcinoma of breast in a patient receiving tamoxifen(Churchill Livingstone, 2002) Meydanli, MM; Karadag, N; Ataoglu, O; Kafkasli, AThe established relationship between tamoxifen and the development of endometrial cancer causes differential diagnostic problems between metastatic and primary uterine neoplasms. A 45-year-old woman underwent modified radical mastectomy because of left-breast cancer. She presented with abnormal vaginal bleeding 6 years later, while still on tamoxifen therapy. The endometrial curettage revealed undifferentiated adenocarcinoma. She underwent total abdominal hysterectomy, bilateral salphingoopherectomy as well as pelvic and periaortic lymphadenectomy. Microscopic examination revealed neoplastic cells which formed sheets and duct-like structures in the endometrium. The pattern was not that of a primary endometrial tumour and an immunohistochemical staining was performed using human breast gross cystic disease fluid protein-15 (GCDFP-15) which was found out to be positive in the tumour cells. A diagnosis of metastatic ductal carcinoma of the breast in the uterus was rendered. Uterine metastasis should be kept in mind in patients with a history of breast cancer who are on tamoxifen therapy. (C) 2002 Elsevier Science Ltd. All rights reserved.
