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    Body Mass Index is Associated with Immunohistochemical Nuclear Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Expression in Stage IB-IC Endometrioid Endometrial Carcinoma
    (Galenos Yayincilik, 2007) Meydanli, Mutlu; Karadag, Nese; Kose, Faruk; Tulunay, Gokhan; Ozfuttu, Ahrnet
    Objective: To examine the relationship between clinicopathologic features and nuclear phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression in a homogeneous group of Stage IB-IC sporadic endometrioid endometrial cancer (EEC) patients. Materials and Methods: This study was conducted on 65 consecutive EEC patients with FIGO Stage IB-IC disease who underwent initial complete surgical staging. Age, body mass index (BMI), tumor grade, immunohistochemical nuclear PTEN expression and clinical outcome were examined. The median follow-up period was 49 months (range, 8 to 78 months). Results: Immunohistochemical staining revealed positive nuclear PTEN expression in 20 cases (30.8%). Nuclear PTEN was found out to be reduced in 36 cases (55.4%), whereas it was completely lost in nine cases (13.8%). After evaluating the staining status, 45 cases (69.2%) were judged as negative for nuclear PTEN expression. During the follow-up period, clinical recurrence of disease was documented in five of 65 women (7.7%). The 5-year disease free survival rate for patients with positive nuclear PTEN expression was similar to that for patients with negative nuclear PTEN expression (75.2% vs. 91.3%, respectively; p =0.728 [log-rank test]). The mean body mass index (BMI) of positive nuclear PTEN expressing cases was significantly greater than that of patients with negative nuclear PTEN expression (32.5 +/- 6.5 vs. 28.5 +/- 5.0, respectively; p =0.009). Discussion: Lost/reduced nuclear PTEN expression was frequent in FIGO Stage IB/IC EEC. BMI is the only clinicopathologic variable affecting immunohistochemical nuclear PTEN expression.
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    Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome
    (Taylor & Francis Ltd, 2011) Turkcuoglu, Ilgin; Engin-Ustun, Yaprak; Turan, Fahri; Kali, Zercan; Karabulut, Aysun Bay; Meydanli, Mutlu; Kafkasli, Ayse
    Objective. To evaluate the asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in obese and lean patients with polycystic ovarian syndrome (PCOS) and find out their relation with hormonal and metabolic parameters. Methods. Twenty-two obese, 18 lean patients with PCOS and 11 obese, 24 lean healthy control patients were enrolled prospectively. Plasma ADMA and NO levels and arginine/ADMA ratio were evaluated on 3rd day of menstrual cycle after at least 10 h overnight fasting. Results. Plasma ADMA, NO levels and arginine/ADMA ratio were similar in the groups. ADMA level did not correlate with the hormonal and metabolic parameters in patients with PCOS. However, NO correlated inversely with fasting insulin (r = -0.353, p = 0.041) and homeostasis model of insulin resistance (HOMA-IR) (r = -0.379, p = 0.027). Arginine/ADMA ratio also correlated inversely with fasting insulin (r = -0.339, p = 0.050). In multinomial regression analysis the risk of low NO was associated independently with high fasting insulin (OR = 1.19, 95% CI 1.001-1.42, p = 0.049) and high HOMA-IR in patients with PCOS (OR = 2.26, 95% CI 1.03-4.98, p = 0.042). Conclusions. Insulin resistance may be the underlying mechanism of endothelial dysfunction through NO pathway in PCOS.