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Öğe Damaging Effects of Total Parenteral Nutrition Formula on Vascular Endothelium(Lippincott Williams & Wilkins, 2015) Demircan, Mehmet; Gurunluoglu, Kubulay; Karaman, Abdurrahman; Mizrak, BulentObjectives: Sepsis in one of the most serious complications that can occur during total parenteral nutrition (TPN) procedures. In this experimental study, we investigated the effects of TPN, with or without lipid emulsion, on vascular endothelial damage. Methods: In total, 50 rabbits were used, divided into 5 groups of 10 each. TPN with lipids (group 1), TPN without lipids (group 2), and 0.09% saline (group 3) were given for 10 days via a central venous catheter. Group 4 received no treatment other than placement of a central venous catheter for 10 days. Group 5 was a control group. At the end of day 10, rabbits were sacrificed and tissue samples of liver, kidney, and inferior vena cava were prepared and examined by immunohistochemical methods for vascular cellular adhesion molecule (VCAM)-1 expression. Results: In tissue sections of liver, kidney, and inferior vena cava, VCAM-1 activity was increased prominently in TPN with and without lipids compared with the control group. VCAM-1 activity in the TPN with lipids group was decreased versus the TPN without lipids group (P > 0.05). Conclusions: The TPN procedure results in vascular endothelial cell damage not only in the vein where the solution is introduced but also in other parts of the vascular system. Even if it is not statistically significant, lipids in the TPN formula may decrease this endothelial cell damage, as shown by immunohistochemistry.Öğe Investigation of microorganisms in cases of mammary duct ectasia by histochemical methods(Springer, 2007) Gurses, Iclal; Karabacak, Tuba; Mizrak, Bulent[Abstract Not Available]Öğe Myelodysplastic Syndrome in an Acromegaly Patient: A Case Report(Galenos Yayincilik, 2005) Sari, Ramazan; Demirel, Ulvi; Sahin, Ibrahim; Aydogdu, Ismet; Mizrak, Bulent; Taskapan, HulyaAcromegaly patients have higher incidence of neoplasia than the general population, especially for colonic carcinoma. Recently, various hematological malignancies have been reported in patients with acromegaly. However, myelodysplastic syndrome has not been reported in acromegaly previously. In this paper, we reported a unique patient with acromegaly and concomitant pancytopenia and myelodysplastic syndrome.Öğe Traumatic Thrombosis of Internal Carotid Artery Sustained by Transfer of Kinetic Energy(Lippincott Williams & Wilkins, 2012) Kalcioglu, Mahmut Tayyar; Celbis, Osman; Mizrak, Bulent; Firat, Yezdan; Selimoglu, ErolA 31-year-old male patient with a fatal thrombosis of the internal carotid artery caused by gun shot injury was presented in this case report. The patient was referred to the hospital with a diffuse edema on his left cheek. On otolaryngologic examination, there was a bullet entrance hole at the left mandibular corpus. No exit hole could be found. The finding from his axial computed tomography of neck and paranasal sinuses was normal. On neurological examination, a dense right hemiparesis was observed. In his cerebral angiogram, left common carotid artery was totally obliterated. Diffuse ischemia was observed in the left cerebral hemisphere. Despite intensive interventions, the patient died 4 days after the accident. In the autopsy, a large thrombosis was obtained in the left common carotid artery. This case emphasizes a fatal kinetic energy effect in vascular structures. It is stressed that a gun shot injury could be fatal with its indirect kinetic energy effects at subacute phase.Öğe Verrucous carcinoma of urinary bladder (vol 23, pg 145, 2006)(Aves Yayincilik, Ibrahim Kara, 2007) Usta, Ufuk; Mizrak, Bulent; Guerses, Iclal[Abstract Not Available]
