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    Association between serum 25-hydroxyvitamin d and early recurrent ischemic stroke
    (2020) Ocek, Levent; Ocek, Levent; Mizrak, Soycan
    Aim: Vitamin D deficiency has been reported as a new risk factor for ischemic stroke in recent years. However, the pathophysiological mechanisms between recurrent ischemic stroke and decreased 25-hydroxyvitamin D [25(OH) D] are not clear. The aim of this study is to examine the relationship between initial vitamin D levels and early recurrent stroke in patients presenting with acute ischemic stroke (AIS).Material and Methods: Four hundreds and ten consecutive patients who were followed-up with AIS diagnosis were included in the study. Risk factors for ischemic stroke were questioned and biochemical and cardiac examinations of the patients were performed. Simultaneously, the National Institutes of Health Stroke Scale (NIHSS) was calculated. Patients who had recurrent ischemic stroke obtained retrospectively were from the hospital registry system in last three month. The patients were divided into two groups as those who had recurrent stroke and who did not.Results: A total of 410 patients, 187 of which were female (45.6%) and 223 of which were male (54.4%) with a mean age of 68.12 ± 12.63 (29-99) were included in the study. Early recurrent ischemic stroke was detected in 48 (11.7%) patients in the follow-up. The systolic blood pressure and diastolic blood pressures at the time of first consultation were higher in the recurrent ischemic stroke group compared to the non-recurrent ischemic stroke group (p0.001). Serum total vitamin D and serum parathyroid hormone levels in patients without recurrent stroke were higher as compared with those in patients with recurrent stroke (p0.001). 25(OH) D were significantly associated with stroke recurrence (OR:1.277;Cl 95%, 1.166-1.398; p0.001).Conclusion: Our study showed that decreased serum 25 (OH)D in patients presenting with acute ischemic stroke is associated with recurrent ischemic stroke in the early stage.
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    Evaluation of seasonal variation of vitamin D levels according to demographic criteria
    (2020) Mizrak, Soycan; Ozdemir, Ali Volkan
    Aim: Although vitamin D can be taken with nutrients, it is substantially synthesized in the skin tissue under the influence of the ultraviolet ray which comes from the sunlight. Therefore, the increase in the expression of vitamin D in the body during periods of increased sunlight can be expected. In this study, it was aimed to determine whether the change in the serum vitamin D levels of the patients who applied to Uşak Training and Research Hospital were significant according to age, gender and months of the year. Material and Methods: The serum vitamin D test results of the patients aged 0-80 who applied to the outpatient clinics of the hospital between 1 January and 31 December 2018 were retrospectively obtained from the hospital automation system. Data were analyzed using SPSS 21 software. p0.05 was considered significant.Results: The largest population of 62.253 vitamin D requests is 18-65 age groups. Serum vitamin D levels were found to be 16.18±10.39 ng/ml in the whole population: 15.85±10.49 ng/ml in women and 17.18±10.03 ng/ml in men. The mean value for women was statistically lower than men (p 0.05). There was a statistically significant difference between vitamin D averages in months, the lowest mean value in January (10.74±8.58 ng / ml), the highest value in July (23.29 ±10.6 ng / ml).Conclusion: In this study, the mean levels of vitamin D were found to be insufficient even in the summer months when sunlight was the most effective. This may be due to the fact that the population may benefit from less sunlight or structural variations of the vitamin D-binding proteins in the body may affect the use of vitamin D. Therefore, extensive research is needed to determine the level of clinical effects of vitamin D deficiency.