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  • Küçük Resim
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    Evaluation of dynamic thiol-disulfide balance in children with stage 3-5 chronic kidney disease
    (2019) Cakirca, Gokhan; Nas, Cemal; Guzelcicek, Ahmet; Yilmaz, Kenan
    Aim: We aimed to examine dynamic thiol-disulfide balance, an indicator of oxidative stress, in children with stage 3-5 chronic kidney disease (CKD).Material and Methods: Native thiol (Nt), total thiol (Tt) and disulfide (DS) levels were determined spectrophotometrically in 27 children with CKD (14 non-dialysis, 13 hemodialysis) and 40 healthy controls.Results: Albumin, Nt, Tt and DS levels were markedly lower in CKD patients than in controls. However, the DS/Nt values were not statistically significant between the two groups. When Nt, Tt, DS and DS/Nt values were adjusted for albumin levels, Tt and Nt levels were lower in CKD patients than controls. In the CKD group, Nt and Tt levels were positively correlated with the albumin and estimated glomerular filtration rate and negatively with urea and creatinine. Conclusion: According to these results, decreased Nt and Tt levels in patients with CKD stages 3–5 may be evidence of exposure to oxidative stress. Keywords: Albumin; chronic kidney disease; thiol oxidation; thiol-disulfide balance.
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    Relation of neural tube defects with folic acid use during pregnancy
    (2019) Cetin, Abdurrahman; Gokdemir, Mehmet Tahir; Nas, Cemal; Gokdemir, Gul Sahika
    Aim: The objective of this study was to investigate the rate of neural tube defects (NTD) and the clinical features of newborns of mothers who did not use folic acid (FA) in their pregnancies.Material and methods: The data of a total of 82 newborns, who were diagnosed with meningomyelocele were operated and examined, retrospectively. The newborns were divided into two groups depending on whether their mothers used FA during pregnancy or not. Results: The mothers of 37 (45.1%) newborns used FA during the antenatal period, whereas those of 45 (54.9%) newborns did not.The mean birth weight of the newborns whose mothers did not use FA were lower. Furthermore 9 (25%) newborns whose mothers did not use FA were delivered via cesarean section.The incidence of meningomyelocele was 80% for 45 newborns with NTDs whose mothers did not use FA.Conclusion: Our results revealed that the mean birth weight was lower while the incidence of meningomyelocele was significantly higher in newborn infants whose mothers did not use FA.Keywords: Folic Acid; Pregnancy; Meningomyolocele; Spina Bifida.