Yazar "Nazliel, Bijen" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Behcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study
    (Oxford Univ Press, 2019) Uluduz, Derya; Midi, Ipek; Duman, Taskin; Colakoglu, Sena; Tufekci, Ahmet; Bakar, Mustafa; Nazliel, Bijen
    Objective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).
  • Küçük Resim
    Öğe
    High serum S-100B protein levels within the first 36 hours of acute ischemic stroke predicts high NIHSS scores
    (2020) Yoruk Hazar, Tugba; Nazliel, Bijen; Akyol Gurses, Asli; Batur Caglayan, Hale; Irkec, Ceyla
    Aim: The aim of the present study was to evaluate serum levels of S-100B which is an acidic calcium-binding protein within the first 36 hours following an acute ischemic stroke and to determine the correlation between S-100B levels and National Institutes of Health Stroke Scale (NIHSS) scores. Material and Methods: Fifty patients with ischemic stroke (25 male, 25 female; mean age=64) and 30 healthy volunteers (14 male, 16 female; mean age=61) serving as age and sex matched controls were included in this study. Venous blood samples were taken within the first 36 hours following the acute stroke. The quantitative determination of S-100B in serum was carried out using an enzyme linked immunosorbent assay.Results: Patients with acute ischemic stroke had significantly higher serum S-100B protein concentrations (42 pg/ml) than those of normal controls (31.5 pg/ml) (p0.001). S-100B concentrations were correlated with NIHSS scores (r=0.443; p=0.001), which is considered an indicator of the degree of neurological deficit.Conclusion: The present study demonstrates that S-100B concentrations in both the large artery atherosclerosis (LAA), cardio embolic infarct (CEI) subtypes of acute stroke are increased in the early phases of stroke and are correlated with NIHSS scores upon admission. S-100B appears to be a valuable biomarker of ongoing brain injury.