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    Can Blood Biomarkers Be Used to Assess Oxidative Stress in COPD Patients After Pulmonary Rehabilitation
    (Dove Medical Press Ltd, 2023) Beykumul, Aysegul; Ersoy, Yuksel; Gulbas, Gazi; Neselioglu, Salim
    Purpose: To determine the level of oxidative stress in the body due to pulmonary rehabilitation (PR) with thiols and disulfide and to investigate their relationship with indirect markers such as creatine kinase (CK), creatine kinase - MB (CK-MB), and lactate dehydrogenase (LDH), which show cell destruction.Patients and Methods: Patients with chronic obstructive pulmonary disease (COPD) are included in inpatient and outpatient care. They were evaluated before and after for PR, and an exercise program was prescribed. In addition, native thiol (NT), total thiol (TT), disulfide (DS), LDH, CK, and CK-MB values were tested.Results: The mean age of 21 patients was 63 +/- 7.31 years. Eleven of them were outpatients and 10 of them were inpatients. Most of the patients were male (M/F=20/1, 95.2/4.8%). There was a significant difference in pulmonary function tests (PFT), St. George Respiratory Questionnaire (SGRQ), and 1 repetition maximum (1RM) before and after the treatment (p<0.001). There was a correlation between PFT and 1RM upper extremity. While there was no significant difference between thiols and disulfide, according to GOLD scores, there was a significant difference in patients with level 3-MMRC. No correlation was found between LDH, CK, CKMB, and thiols, DS. Delta CK was found to be associated with Delta DS, and Delta CK-MB with Delta NT, and Delta TT.Conclusion: PR contributes to the antioxidant process by improving respiration and reducing oxidative stress. The decrease in LDH, CK with PR, increase in CK-MB, and correlation of CK with thiols and DS gave a different interpretation. In this case, it should be considered that oxidative stress may also be increased in people with high CK values.
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    DO disease stages affect oxidative stress in stable COPD?
    (Cell Press, 2024) Yalcinsoy, Murat; Beykumul, Aysegul; Gulbas, Gazi; Arslan, Ahmet Kadir; Neselioglu, Salim
    Background: Detection of oxidative stress level may lead us to understand the pathogenesis of COPD better and to search for new treatments. Oxidative stress levels have also been shown to be elevated in stable COPD patients. We aimed to investigate whether the stage of COPD affects the severity of inflammation-induced oxidative stress in patients with stable COPD. Methods: Between June 2019 and March 2020, all consecutive patients admitted to COPD-specific outpatient clinics were included. Patients were classified A, B, and E according to the GOLD guideline. Results: The median age of 98 patients (Male: 92 (93.9 %)) was 65 (min-max: 49-86). A statistically significant difference was found between the groups in FEV1, FVC, and FEV1/FVC (p < 0.001). age, and thiols (r = -0.168, p = 0.049; r = -0.184, p = 0.035) and DS (r = -0.209, p = 0.019) were found to be negatively correlated at a low level. When adjusted for age, oxidative stress parameters were similar between stages. Conclusion: No difference between stages and oxidative stress parameters according to GOLD classification in stable COPD patients. Our results may be a guide for not using anti-inflammatory therapy except for attacks.
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    Dynamic thiol-disulfide balance in patients with chronic sinusitis with and without nasal polyposis
    (2020) Sevil, Ergun; Gul, Fatih; Oguzhan, Tolga; Bercin, Sami; Neselioglu, Salim; Bicer, Cemile
    Aim: Reactive oxygen species (ROS) have a crucial role in the pathogenesis of chronic rhinosinusitis (CRS). The current study investigates a novel oxidative stress marker (thiol (SH)/disulfide (SS) homeostasis) in patients with CRS with and without nasal polyposis (NPs).Materials and Methods: A total of 167 subjects, including 94 patients with CRS and 73 healthy controls, were included in the study. The patients were subdivided into two groups those with CRS with NP and those with CRS without NP. Comparisons were made between the groups in respect of serum native SH, total thiol (TT), and SS levels and the SS/SH and SS/TT ratios. Results: There was no significant difference in TT between the CRS with the NP group and the CRS without the NP group (p> 0.05). There was a significant difference (p 0.05) between the CRS without the NP group and the control group in %SH/TT, %SS/TT, %SS/SH, SS, and SH. A significant difference (p 0.05) was found between the CRS with the NP group and the control group in %SH/TT, %SS/TT, %SS/SH, SS and SH values. Conclusion: Dynamic SH/SS homeostasis shifts towards SS formation as a result of SH oxidation in patients with CRS.
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    The role of thiol/disulfide homeostasis in the differentiation of transudative and exudative pleural effusion
    (2022) Abuzaina, Osama; Hezer, Habibe; Karalezli, Aysegul; Abuzaina, Seray; Neselioglu, Salim; Erel, Ozcan; Hasanoglu, H. Canan
    Aim: The dynamic thiol/disulfide homeostasis performs a major role in keeping up the oxidant-antioxidant equilibrium. We aimed to find the role of dynamic thiol/disulfide balance in pleural effusion transudate-exudate differentiation. This is considered to be the first research investigating the thiol/disulfide homeostasis in pleural fluid. Materials and Methods: This prospective study was conducted in the Clinic of Chest Diseases of Training and Research Hospital. One hundred adult patients with pleural effusion included. 20-100 cc pleural fluid samples were taken through thoracentesis of the patients. These fluids were categorized as exudate and transudate according to Light’s criteria. Automatic spectrophotometric practice which was defined by Erel & Neselioglu was used to gauge thiol/disulfide homeostasis in pleural fluid. Results: Disulfide, total and native thiol levels were significantly higher in the exudative group than the transudative group (p = 0.001). The ratio of disulfide/native thiol and disulfide/total thiol was higher in the transudative group (p = 0.03). In exudates, native thiol/total thiol proportions were higher (p = 0.03). Conclusion: The increased disulfide levels are indicative of increased oxidative stress in exudative pleural fluid. An abnormal thiol/disulfide state may be a major factor in the pathogenesis. These outcomes may conduce to distinguish exudative fluids without requesting synchronous serum thiol/disulfide level measurement.
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    Serum ischemia modified albumin and dynamic thiol/disulfide homeostasis in early- and late-onset preeclampsia
    (2020) Adanas Aydin, Gultekin; Ozgen, Gulten; Neselioglu, Salim; Erel, Ozcan
    Aim: In the present study, we aimed to evaluate serum IMA, IMA/albumin ratio, and DTDH levels in patients with early- and late-onset PE compared to healthy controls.Impaired homeostasis between oxidant and antioxidant mechanisms, inflammatory processes, and endothelial dysfunction play a key role in the pathogenesis of preeclampsia (PE). Serum ischemia modified albumin (IMA) and dynamic thiol/disulfide homeostasis (DTDH) levels are elevated in the presence of inflammation, oxidative stress, and endothelial dysfunction. Material and Methods: A total of 24 patients with early-onset PE and 62 patients with late-onset PE were included.The control group consisted of 46 healthy controls with similar gestational weeks. Serum samples were collected and IMA, albumin, and native, total, and disulfide thiol levels analyzed. Corrected IMA/albumin ratios were also calculated.Results: Disulfide levels, disulfide/native and disulfide/total thiol levels were higher in patients with early-onset PE compared to late-onset patients(p=0.008, p=0.022, and p=0.021, respectively). However, there was no significant difference between the late-onset PE patients and late-onset PE controls. Although there was no significant difference in the IMA levels between the patient and control groups, the IMA/albumin ratio was higher in the early-onset and late-onset PE patients, compared to the control group. However, there was no significant difference between the early-onset and late-onset PE patients.Conclusion: Our study results showed increased disulfide levels, disulfide/native thiol, disulfide/total thiol and IMA/albumin ratio in the early-onset PE patients, indicating increased oxidative stress in the pathogenesis of PE. In the late-onset PE patients, there was an increase only in the IMA/albumin ratio. However, further large-scale, prospective studies are needed to confirm the diagnostic value of these markers in the clinical practice.
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    Thiol/Disulfide Homeostasis in Patients with Central Serous Chorioretinopathy
    (Taylor & Francis Inc, 2016) Turkoglu, Elif Betul; Dikci, Seyhan; Celik, Erkan; Erel, Ozcan; Neselioglu, Salim; Alisik, Murat; Koca, Cemile
    Purpose: To evaluate dynamic thiol/disulfide homeostasis in patients with chronic central serous chorioretinopathy (cCSC).Methods: This prospective study included 34 cCSC cases and 37 healthy individuals who were age- and sex-matched. A new colorimetric method for measuring thiol/disulfide homeostasis was used. Native thiol, total thiol/disulfide levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were measured.Results: The age and gender distributions were similar in both main groups. The mean duration of disease was 47.29 24 months. Native and total thiol levels were significantly lower among the cCSC group relative to the control group (p < 0.001). There was not a statistically significant difference between the cCSC and the control group in terms of disulfide levels (p = 0.492). While disulfide/native thiol and disulfide/total thiol ratios were elevated, the native thiol/total thiol ratio was decreased in the cCSC group (p = 0.017, 0.021, 0.036, respectively). Ratios obtained using plasma native thiol, total thiol, and disulfide levels differed significantly between the both groups.Conclusion: Disulfide/thiol ratio was significantly greater in cCSC patients relative to healthy control subjects. Our results suggest that the oxidative process is involved in the pathogenesis of the cCSC.