Yazar "Noma, Samir A. A." seçeneğine göre listele

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    Chitosan/Polyvinylpyrrolidone/MCM-41 Composite Hydrogel Films: Structural, Thermal, Surface, and Antibacterial Properties
    (Wiley-V C H Verlag Gmbh, 2018) Ulu, Ahmet; Noma, Samir A. A.; Gurses, Canbolat; Koytepe, Suleyman; Ates, Burhan
    The aim of this study is to characterize and investigate the effects of the Mobil Composition of Matter No. 41 (MCM-41) concentrations (0.5, 1, 3, 5, and 10 wt%) on structural, thermal, wettability, water content, oxygen (O-2) permeability, and swelling properties as well as morphological characteristics of chitosan/polyvinylpyrrolidone/MCM-41 (CH/PVP/MCM-41) composite hydrogel films. In addition, hydrolytic degradability, optic transmittance, and antibacterial properties of composite hydrogels films are determined as in vitro. With increasing of MCM-41 content, the composite hydrogels showed higher thermal stability, as expected. The morphologic properties of the composite hydrogel films are studied using scanning electron microscope (SEM) technique that provide evidence for good miscibility of CH, PVP, and MCM-41. The swelling and water-absorbing properties of the composite hydrogel films are significantly improved because of enhanced hydrophilic profile. Furthermore, the antimicrobial properties of the prepared composite hydrogel films are studied against Bacillus subtilis, Escherichia coli, and Candida albicans yeast. The results showed excellent antibacterial behavior of the composite hydrogel films. The study clearly demonstrates that the prepared CH/PVP/MCM-41 composite hydrogel films may be used as a promising candidate material in various fields such as drug delivery, wound healing material, and adsorbent materials.
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    Novel hybrid isoindole-1,3(2H)-dione compounds containing a 1H-tetrazole moiety: Synthesis, biological evaluation, and molecular docking studies
    (Wiley, 2022) Tan, Ayse; Kizilkaya, Serap; Noma, Samir A. A.; Ates, Burhan; Kara, Yunus
    In this study, novel hybrid isoindole-1,3(2H)-dione compounds (10 and 11) carrying a 1H-tetrazole moiety were synthesized, characterized and their inhibitory properties against xanthine oxidase (XO) and carbonic anhydrase isoenzymes (hCA I and hCA II) were investigated. Allopurinol for XO and acetazolamide for carbonic anhydrase isoenzymes were used as positive standards in inhibition studies. In addition, compounds 8 and 9, which were obtained in the intermediate step, were also investigated for their inhibition effects against the three enzymes. According to the enzyme inhibition results, hybrid isoindole-1,3(2H)-dione derivatives 10 and 11 showed significant inhibitory effects against all three enzymes. Surprisingly, compound 8, containing a SCN functional group, exhibited a greater inhibitory effect than the other compounds against hCA I and hCA II. The IC50 values of compound 8 against hCA I and hCA II were found to be 3.698 +/- 0.079 and 3.147 +/- 0.083 mu M, respectively. Compound 8 (IC50 = 4.261 +/- 0.034 mu M) showed higher activity than allopurinol (IC50 = 4.678 +/- 0.029 mu M) and the other compounds against XO, as well. These results clearly show the effect of the SCN group on the inhibition. In addition, in silico molecular docking studies were performed to understand the molecular interactions between each compound and enzymes, and the results were evaluated.
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    Water Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluation
    (Wiley-V C H Verlag Gmbh, 2020) Karatas, Mert O.; Noma, Samir A. A.; Gurses, Canbolat; Balcioglu, Sevgi; Ates, Burhan; Alici, Bulent; Cakir, Umit
    In the present study, coumarin-bearing three pyridinium and three tetra-alkyl ammonium salts were synthesized. The compounds were fully characterized by(1)H- and(13)C-NMR, LC/MS and IR spectroscopic methods and elemental analyses. The cytotoxic properties of all compounds were tested against human liver cancer (HepG2), human colorectal cancer (Caco-2) and non-cancer mouse fibroblast (L-929) cell lines. Some compounds performed comparable cytotoxicity with standard drug cisplatin. Antibacterial properties of the compounds were tested against Gram-negativeEscherichia coliand Gram-positiveBacillus subtilisbacteria, but the compounds did not have any antibacterial effect against both bacteria. Enzyme inhibitory properties of all compounds were tested on the activities of human carbonic anhydrase I and II, and xanthine oxidase. All compounds inhibited both enzymes more effectively than standard drugs, acetazolamide and allopurinol, respectively. The biological evaluation results showed that ionic and water soluble coumarin derivatives are promising structures for further investigations especially on enzyme inhibition field.