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    The chromosomal abnormalities associated defects and outcomes of fetuses diagnosed prenatally with clubfoot
    (2021) Obut, Mehmet; Tolunay, Harun Egemen; Yucel Celik, Ozge; Cayonu Kahraman, Neval; Arat, Ozgur; Ozlu Unal, Merve; Celen, Sevki
    Aim: To assess associated findings, chromosomal abnormalities and outcomes of the pregnancies diagnosed with fetal clubfoot. Materials and Methods: Ultrasonographic characteristics, pregnancy work-up and fetal outcomes of the pregnancies diagnosed with fetal clubfoot between January 2015 and October 2019 were evaluated retrospectively. Clubfoot was considered as complex or isolated depending on the presence or absence of additional structural abnormalities. The results of cases, which grouped according to the presence of additional abnormalities and laterality, were compared. Results: A total data of 46 pregnancies diagnosed with fetal clubfoot during the study period were included. The most associated abnormality with clubfoot was central nervous system (CNS) anomalies. Nineteen (41%) of fetuses were considered complex, and 27 (59%) were considered isolated. The ratio of the cases with poor outcomes was higher in the complex group than in the isolated group and was 15 (79%) and 1(3%) respectively (p=0.000 for bilateral group and p=0.013 for unilateral group). There were 7 (36%) cases with a chromosomal abnormality in the complex group and 1(4%) case in the isolated group. The deformity was unilateral in 16 (35%) and bilateral in 30 (65%) cases. The rate of poor outcomes was not different in cases with bilateral and unilateral clubfoot deformity (p=0.356). Conclusion: The prognosis of the fetuses diagnosed with clubfoot mostly depends on associated abnormalities. Therefore a careful evaluation of these fetuses must be performed even if karyotyping is normal. The laterality did not have any impact on the prognosis of cases with clubfoot.
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    Subclinical hypothyroidism of unexplained infertility patients does not affect intrauterine insemination success: A case-control study
    (2021) Oglak, Suleyman Cemil; Obut, Mehmet
    Aim: This study aimed to assess the importance of preconceptional thyroid-stimulating hormone (TSH) values on the achievement of intrauterine insemination (IUI) in unexplained infertile patients. Materials and Methods: This study was conducted retrospectively by evaluating the medical records of euthyroid 192 patients who experienced IUI between January 2017 and December 2018. The study population was classified as serum TSH levels of 0.5-2.49 mIU/L (group A) and 2.5-4.5 mIU/L (group B). Clinical pregnancy, miscarriage and live birth rates of the groups were evaluated. Results: The demographic characteristics, laboratory levels, and cycle characteristics of the study population were similar. There were no statistically significant differences between group A and group B in terms of clinical pregnancy (11.03%, and 8.51%, respectively, p=0.62), miscarriage (3.55%, and 1.13%, respectively, p=0.65), and live birth rates (7.58%, and 6.38%, respectively, p=0.78). Conclusion: Clinical pregnancy, miscarriage, and live birth rates were similar between the two groups. We indicate that subclinical hypothyroidism does not adversely affect the clinical pregnancy, miscarriage, and live birth rates in IUI cycles of euthyroid unexplained infertile couples.