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    Öğe
    High expression of CD8 in the tumor microenvironment is associated with PD-1 expression and patient survival in high-grade serous ovarian cancer
    (Galenos Publ House, 2022) Olmez, Fatma; Oglak, Suleyman Cemil; Olmez, Omer Fatih; Akbayir, Ozgur; Yilmaz, Ercan; Akgol, Sedat; Konal, Merve
    Objective: The current study assesss programmed death-1 (PD-1) receptor expression and CD3, CD4, and CD8 tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) and to associate our results with neoadjuvant chemotherapy history and disease prognosis. Materials and Methods: We included cases diagnosed with primary HGSOC with biopsy or surgical resection materials in this study. The immunoreactivity of CD3, CD4, CD8, and PD1 was assessed immunohistochemically in tumor tissue. We analyzed TILs in two predetermined groups of high and low TIL. The relationships between clinical characteristics, PD-1, and TIL were assessed. by the chi((2)) test or Fisher's Exact test. We used Kaplan-Meier survival analysis and Cox proportional hazards regression model to the connection between survival and the amounts of TIL, and PD1. Results: Univariate analysis demonstrated that optimal debulking (p<0.001), early International Federation of Gynecology and Obstetrics stage (p=0.046), and higher scores of stromal CD8+ TIL expression (p=0.028) in tumor cells were all substantially correlated with longer disease-free survival (DFS), whereas the remaining variables analyzed, including PD-1 positivity, stromal CD3+, and CD4+ TILs, and intraepithelial CD3+, CD4+, and CD8+ TILs, were not correlated with DFS. Also, univariate analysis revealed that optimal debulking (p=0.010), and higher scores of stromal CD8+ TIL expression (p=0.021) in tumor cells were all substantially correlated with longer overall survival (OS). Conclusion: Higher scores of stromal CD8+ TILs are substantially correlated with DFS and OS in univariate analyses, whereas scores of stromal CD3+ and CD4+ TILs, and intraepithelial CD3+, CD4+, and CD8+ TILs are not correlated with DFS and OS in both univariate and multivariate analyses. Also, we found a significant association between PD-1 positivity and the scores of stromal CD3+ TILs and intraepithelial CD8+ TILs. However, no remarkable relationship was revealed between PD-1 positivity and the survival of HGSOC cases.
  • Küçük Resim
    Öğe
    Subclinical hypothyroidism of unexplained infertility patients does not affect intrauterine insemination success: A case-control study
    (2021) Oglak, Suleyman Cemil; Obut, Mehmet
    Aim: This study aimed to assess the importance of preconceptional thyroid-stimulating hormone (TSH) values on the achievement of intrauterine insemination (IUI) in unexplained infertile patients. Materials and Methods: This study was conducted retrospectively by evaluating the medical records of euthyroid 192 patients who experienced IUI between January 2017 and December 2018. The study population was classified as serum TSH levels of 0.5-2.49 mIU/L (group A) and 2.5-4.5 mIU/L (group B). Clinical pregnancy, miscarriage and live birth rates of the groups were evaluated. Results: The demographic characteristics, laboratory levels, and cycle characteristics of the study population were similar. There were no statistically significant differences between group A and group B in terms of clinical pregnancy (11.03%, and 8.51%, respectively, p=0.62), miscarriage (3.55%, and 1.13%, respectively, p=0.65), and live birth rates (7.58%, and 6.38%, respectively, p=0.78). Conclusion: Clinical pregnancy, miscarriage, and live birth rates were similar between the two groups. We indicate that subclinical hypothyroidism does not adversely affect the clinical pregnancy, miscarriage, and live birth rates in IUI cycles of euthyroid unexplained infertile couples.