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Öğe Aminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats(Wiley, 2013) Oguz, F.; Ciftci, O.; Aydin, M.; Timurkaan, N.; Beytur, A.; Altintas, R.; Parlakpinar, H.In this study, it was aimed to determinate protective effects of aminoguanidine (AG) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. Thirty-two rats were equally divided into four groups; the first group was kept as control and given corn oil as carrier. In second and third groups, TCDD and AG were orally administered at the dose of 2 mu k g(-1) per week and 100 mg kg(-1) per day for 45 days, respectively. In fourth group, TCDD and AG were given together at the same doses. Although TCDD significantly increased the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx and SOD in rats. On the other hand, AG, given together TCDD, reversed TCDD effects on TBARS SOD, GSH, GPx and CAT. In addition, sperm characteristics negatively affected and histopathological deformation occurred with TCDD exposure. However, AG treatment partly prevented these toxic effects of TCDD on spermatological parameters and histopathological changes. In conclusion, TCDD exposure induces testicular damage (oxidative stress, histopathological damage and sperm parameters), and AG treatment reversed TCDD-induced testicular damage in rats. Thus, AG may be useful for the prevention and treatment of TCDD-induced male infertility problems.Öğe Comparison of results after flouroquinolons and combination therapies in type IIIA chronic prostatitis(Ene Ediciones Sl, 2013) Altintas, R.; Oguz, F.; Beytur, A.; Ediz, C.; Gunes, A.; Ozer, A.Purpose: We investigated retrospectively the clinical outcomes of the patients with type III inflammatory chronic prostatitis, who were treated with fluoroquinolones with and without an alpha-blocker between 2009-2011. Material and methods: Diagnosis was established with medical history (symptoms presented Longer than 3 months within previous 6 months), physical examination, Meares-Stamey test and the questionnaire of the NIH-CPSI. The responses to the treatment were assessed with uroflowmetry test and the questionnaire of NIH-CPSI at initial and after 4 weeks of the treatment. The patients with incomplete data and treatment and who treated with alpha-blockers and/or antibiotics in the period 4 weeks prior to the therapy started in our clinic and had any surgery of lower urinary tract previously were excluded. The patients were classified under 6 groups; group1 = ciprofloxacin, group2 = ofloxacin, group3 = levofloxacin, group4 = ciprofloxacin+tamsulosin, group5 = ofloxacin+tamsulosin, group 6 = levofloxacin+tamsulosin. Wilcoxon Signed Ranks and Kruskal Wallis test were used for comparison of results. Mann Whitney U test with Bonferroni correction made was used as posthoc (P < .05). Results: The median scores of NIH-CPSI decreased significantly in all groups (P < .05). Levofloxacin reduced the median total scores of NIH-CPSI more than ciprofloxacin and ofloxacin monotherapies. The combination therapies were better than antibiotic therapies alone and best result was obtained in levofloxacin + tamsulosin combination. Conclusion: Tamsulosin + fluoroquinolone (especially tamsulosin + levofloxacin) combinations yielded better results in both NIH-CPSI scores and peak flow rates. (C) 2012 AEU. Published by Elsevier Espana, S.L. All rights reserved.Öğe The effect of melatonin on acetylsalicylic acid-induced kidney and testis damage(Sage Publications Ltd, 2014) Altintas, R.; Polat, A.; Parlakpinar, H.; Vardi, N.; Beytur, A.; Oguz, F.; Sagir, M.The aim of this study was to evaluate the acute effect of high-dose acetylsalicylic acid (ASA) on kidney and testis, and the potential protective and therapeutic effects of melatonin on ASA-related pathology. A total of 40 rats were randomly divided into the following 5 groups (n = 8): group 1: control, not given any drug; group 2: only 200 mg/kg ASA was given; group 3: 5 mg/kg melatonin was given 45 min before administering 200 mg/kg ASA; group 4: 5 mg/kg melatonin was given 45 min after administering 200 mg/kg ASA; and group 5: only 5 mg/kg melatonin was given. The histopathological changes and the biochemical findings; such as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), and blood urea nitrogen (BUN) as well as serum creatinine (Cr) levels were evaluated. ASA significantly increased MDA levels in both kidney and testis, whereas it significantly decreased the values of SOD, CAT, GPX, and GSH in kidney and CAT levels in testis. Melatonin significantly decreased MDA levels in kidney and ameliorated it in testis, whereas it caused elevation in the levels of antioxidants. BUN and Cr levels were higher after ASA, whereas these levels were diminished after melatonin administration. The improvement obtained by melatonin on ASA-induced histological alterations was more prominent when it was used after ASA in kidney and before ASA in testis. In this study, we demonstrated the beneficial effect of melatonin on high-dose ASA-related pathology of kidney and testis for the first time.Öğe EFFECTS OF EXERCISE ON VARICOCELE(Elsevier Science Bv, 2010) Soylemez, H.; Beytur, A.; Oguz, F.; Kahraman, B.; Soylu, A.[Abstract Not Available]Öğe EFFECTS OF MICRONISED PURIFIED FLAVONOID FRACTION AND OXERUTIN ON PAIN, SPERMIOGRAM AND SCROTAL COLOR DOPPLER PARAMETERS IN PATIENTS WITH PAINFUL VARICOCELE(Elsevier Science Bv, 2010) Soylemez, H.; Beytur, A.; Kilic, S.; Oguz, F.; Karademir, I; Koplay, M.[Abstract Not Available]Öğe Fish oil, contained in eicosapentaenoic acid and docosahexaenoic acid, attenuates testicular and spermatological damage induced by cisplatin in rats(Wiley, 2014) Ciftci, O.; Cetin, A.; Aydin, M.; Kaya, K.; Oguz, F.The aim of this study was to investigate the beneficial effects of the fish oil (FO) supplementation on oxidative stress, sperm characteristics and histological alterations in the male reproductive system of rats against cisplatin (CP) toxicity. The rats were divided randomly into 4 equal groups (control, FO, CP and FO+CP). FO was orally administered at the dose of 1softgel per rat per day for 14days and CP was intraperitoneally given at the dose of 7mgkg(-1) with a single injection. In CP+FO group, they were applicated at the same doses and times. The results showed that CP caused a significant oxidative damage via induction of lipid peroxidation and reduction in the antioxidant defence system potency in the testis tissue. In addition, sperm motility and sperm concentration significantly decreased but the abnormal sperm rate and histopathological testicular damage increased with CP treatment. On the other hand, FO treatment prevented oxidative, histopathological and spermatological effects of CP and reversed side effects of CP. In conclusion, FO supplementation had significant beneficial effects against CP toxicity on male reproductive system and toxic effects of CP can be prevented by FO treatment. Therefore, it appears that fish oil may be useful for the prevention and treatment of cisplatin-induced reproductive system toxicity.Öğe Lycopene prevents experimental priapism against oxidative and nitrosative damage (vol 18, pg 3320, 2014)(Verduci Publisher, 2021) Ciftci, O.; Oguz, F.; Beytur, A.; Polat, F.; Altintas, R.; Oguzturk, H.[Abstract Not Available]Öğe OUR EXPERIENCES OF HEMOSTASIS WITH PERCUTANEOUS CAUTERIZATION IN PERCUTANEOUS NEPHROLITHOTOMY CASES(Elsevier Science Bv, 2010) Oguz, F.; Soylemez, H.; Beytur, A.; Soylu, A.; Gunes, A.[Abstract Not Available]Öğe OUTCOME OF TIPU TECNIQUE IN CHILDREN AND ADULTS WITH PRIMARY DISTAL AND MIDPENIL HYPOSPADIAS(Elsevier Science Bv, 2010) Soylemez, H.; Oguz, F.; Beytur, A.; Burgu, B.; Soylu, A.[Abstract Not Available]Öğe Quercetin prevents docetaxel- induced testicular damage in rats(Wiley, 2015) Altintas, R.; Ciftci, O.; Aydin, M.; Akpolat, N.; Oguz, F.; Beytur, A.The protective effect of quercetin on docetaxel - an anticancer agent - induced testicular damage in rats was investigated. Thirty-two rats were randomly divided into four groups: group 1 - control, carrier solutions were given; group 2 - quarcetin 20mgkg(-1)day(-1) was given orally; group 3 - docetaxel 5mgkg(-1) was given intraperitoneally as single dose; group 4 - docetaxel and quarcetin were given together. The histopathological changes; the specific biochemical markers, including antioxidants; and the sperm characteristics were evaluated. Docetaxel caused a significant increase in TBARS level and a significant decrease in SOD, GPX, CAT and GSH levels in the testicular tissues compared with the control group, whereas quercetin led to a significant decrease in lipid peroxidation, which was caused by docetaxel, via reducing TBARS level and increasing the levels of SOD, CAT, GPX and GSH. In addition, after docetaxel administration, sperm motility, sperm concentration, testicular and epididymis weights were significantly decreased and abnormal sperm rate and histopathological changes were increased. However, these effects of docetaxel on sperm parameters, histological changes and the tissue weights were eliminated by quercetin treatment. Our results show that the administration of docetaxel induced the testicular damage (oxidative stress, testes tissue damage and sperm parameters), and quercetin prevented docetaxel-induced testicular damage in rats.
