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Öğe Ameliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced nephrotoxicity in rats(Sage Publications Inc, 2012) Ciftci, Osman; Ozdemir, Ilknur; Vardi, Nigar; Beytur, Ali; Oguz, FatihThe aim of this study is to investigate the beneficial effects of the quercetin (Q) and chrysin (CH) against nephrotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, in rats. Rats were divided randomly into six equal groups. TCDD, Q and CH were administered by gavages dissolved in corn oil at the doses of 2 mu g/kg/week, 20 mg/kg/day and 50 mg/kg/day, respectively. The kidney samples were taken from all rats on day 60 for the determination of thiobarbituric acid reactive substances (TBARS), glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels by spectrophotometric method. The results indicated that TCDD significantly induced lipid peroxidation and reduced antioxidant activities in rats. In contrast, Q and CH significantly prevented toxic effects of TCDD via increased GSH, CAT, GPx and SOD levels but decreased formation of TBARS. Also, it was determined that exposure to TCDD leads to significant histological damage in kidney tissue, and these effects can be eliminated with Q and CH treatment. In conclusion, the current study showed that exposure to TCDD can exert nephrotoxicity in rats. When Q and CH were given together with TCDD, they prevented nephrotoxic effects of TCDD. Their preventive effect lends more support to the role of oxidative and histological damage in the overall toxicity of TCDD.Öğe ASSESSMENT OF FEMALE PATIENTS PRESENTING WITH URINARY INCONTINENCE(Mary Ann Liebert, Inc, 2012) Altintas, Ramazan; Oguz, Fatih; Beytur, Ali; Kati, Bulent; Gunes, Ali[Abstract Not Available]Öğe Assessment of urinary incontinence in the women in Eastern Turkey(Springer London Ltd, 2013) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Tasdemir, Cemal; Kati, Bulent; Cimen, Serhan; Colak, CemilThe aims of the present study were to determine the types of UI among women visiting the urology department, to identify the potential risk factors associated with each type of UI, and to identify healthcare-seeking behaviors of affected women in our region. The data of 617 community-dwelling women, who were at least 18 years of age or older and who presented with a complaint of UI ongoing over a year, and those without UI, who were admitted for any other reason, from June 2010 to April 2012, were evaluated. Mean age was 51.29 years (range 18-110 years); median parity was 3.54 (range 0-11) and 88.2 % of the women were married. Mean BMI was 28.01 kg/m(2). Very few women (18.5 %) accepted UI as a disease and searched for medical help by themselves; however, the remaining women (81.5 %) were brought or directed for evaluation by someone else. Stress UI was reported by 43 women (10.5 %), urge UI and mixed UI were noted by 153 (37.5 %) and 212 (52 %) women respectively. The most frequent type of UI was mixed UI in our region. Age, BMI, multiparity, and hypertension were identified to have a different importance for each type of UI, but diabetes mellitus, birth trauma, gynecological surgery, lumbar disc hernia (LDH), and multiple sclerosis (MS) were the other important related factors. However, a small number of patients accepted UI as a disease and searched for therapy. This reveals that the public should be informed in detail about female UI in developing countries.Öğe Bilateral Ureteral Stones Causing Anuria: A Case Report(Aves, 2015) Gur, Ali; Turtay, Muhammet Gokhan; Gurbuz, Sukru; Oguztruk, Hakan; Sarihan, M. Ediz; Oguz, Fatih; Derya, SerdarIntroduction: Bilateral ureteral stone is not known to frequently result in anuria during emergency. Case Report: An 18-year-old male patient was admitted to an emergency department with the complaint of sudden inability to urinate. He did not mention any additional complaints. On conducting a physical examination, we could not detect any pathological findings. From the patient's blood tests, potassium and creatinine levels were found to be 6.4 mmol/L and 9.81 mg/dL, respectively. Subsequently, we found bilateral ureteral stones on ultrasonography and non-contrast spiral computed tomography. Urology consultation was requested. The patient undergoing emergency surgery had ureterorenoscopy, bilateral endoscopic retrograde basket, and DJ stents procedures done by urology. During the follow-up, the patient was able to urinate, and his creatinine and potassium levels decreased. The patient was discharged. Conclusion: For patients admitted with complaint of anuria, we should keep in mind that the patient could have bilateral ureteral stones; therefore, he or she may have acute kidney failure and may subsequently require emergency surgery.Öğe Comparing 2% lidocaine gel (Dispogel and Cathejell) in cystoscopy(Sage Publications Ltd, 2019) Ucar, Muharrem; Oguz, Fatih; Gecit, Ilhan; Aydogan, Mustafa SaidObjective Cystoscopy is a common urologic procedure. Analgesics are often used to reduce any pain associated with this procedure. The aim of this study was to investigate the efficacy in reducing pain and the cost-effectiveness of two forms of lidocaine gel in patients undergoing cystoscopy. Methods In this double-blind, randomized clinical trial, 77 male patients who were referred for double J removal, urethral dilatation, or cystoscopy were enrolled. The patients were divided into two groups: Dispogel and Cathejell. All patients received 20 mL of intraurethral lidocaine gel 2% and cystoscopy was performed 5 minutes thereafter. The primary outcome was the pain score (visual analogue scale, VAS) during and 5 minutes after cystoscopy. Results There were no statistically significant differences between the VAS scores, blood pressure, and pulse rate in the groups in either observation period. No patient required additional anesthetic agents or sedatives for insufficient pain relief. Conclusion The results of this study show that the analgesic efficacy of Dispogel and Cathejell in the treatment of pain during and after elective cystoscopy was the same, but Dispogel was more cost-effective.Öğe The effect of periodontal treatment in improving erectile dysfunction: a randomized controlled trial(Wiley, 2013) Eltas, Abubekir; Oguz, Fatih; Uslu, Mustafa Ozay; Akdemir, EnderObjective The aim of the study was to evaluate changes in the International Index of Erectile Dysfunction (IIEF) score following periodontal treatment in patients who had severe or moderate erectile dysfunction (ED) and chronic periodontitis (CP). Materials and methods The authors declare that they have no conflict of interest. The study population consisted of 120 patients with severe or moderate ED and CP. The treatment group (n = 60) comprised patients who received periodontal treatment, whereas the control group (n = 60) comprised patients who did not receive periodontal treatment. The clinical assessments were recorded at baseline, and at 1 month (R1) and 3 months (R2) after intervention for both groups. The periodontal examination involved assessment of the plaque index, bleeding on probing, probing depth and clinical attachment level. The IIEF questionnaire was used to assess the severity of ED. Results In the treatment group, the improvement in all clinical periodontal parameters was greater than that in the control group, at both R1 and R2 (p < 0.05). The increase in the IIEF scores of the treatment group at R2 was higher than that of the control group (p < 0.05), whereas the IIEF scores were similar for both groups at R1 (p > 0.05). Conclusion The findings of the study suggest that periodontal treatment can provide additional benefits in the improvement of ED. However, further studies are needed to understand the mechanisms of interaction between these diseases.Öğe EFFECT OF SELECTION OF ACCESS CALYX ON SUCCESS OF PERCUTANEOUS NEPHROLITHOTOMY(Mary Ann Liebert, Inc, 2012) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Cimen, Serhan[Abstract Not Available]Öğe Effects of acute exercise on the diameter of the spermatic vein, and duration of reflux in patients with varicocele(Informa Healthcare, 2013) Atar, Murat; Soylemez, Haluk; Oguz, Fatih; Beytur, Alt; Altunoluk, Bulent; Kahraman, Bayram; Islamoglu, YahyaObjective. The aim of this study was to investigate the effects of acute exercise on the diameter of the spermatic vein, and on the duration of reflux in patients with varicocele. Material and methods. The study included 38 patients with complaints of infertility and scrotal pain between 2009 and 2010. The diagnoses were made by physical examination and colour Doppler ultrasound, with both performed before and after exercise tests. Results. The mean age of the participants was 25.7 +/- 4.9 years. During the first examination, the grades of the varicoceles detected were as follows: grade I, n = 7; II, n = 10; and III, n = 21. The diameters of veins in patients with grades I, II and III varicocele were 2.1 mm, 2.9 mm and 4.2 mm, respectively, before exercise, whereas they were 2.6 mm, 3.2 mm and 4.3 nun, respectively, after exercise. In patients with grade I varicoceles, compared with pre-exercise values, the diameter of the left spermatic vein and duration of reflux measured during Valsalva manoeuvres were increased significantly after exercise (p = 0.042 and p = 0.034, respectively); similar results were obtained for the patients with grade II varicoceles (p = 0.007 and p = 0.008, respectively). However, the minimal relative increase in cases with grade III varicoceles was not statistically significant (p > 0.05). Conclusions. This study demonstrates that acute exercise increases the spermatic vein diameter and reflux time in patients with varicoceles. These outcomes demonstrate that acute exercise may be an aggravating factor for varicocele, as seen in chronic exercise.Öğe Efficacy and safety of Hyadex for treatment of vesicoureteral reflux: a multicenter experience(Sage Publications Ltd, 2023) Oguz, Fatih; Yildiz, Turan; Gecit, Ilhan; Gungor, Hasan; Ciftci, Halil; Aksoy, Yilmaz; Yagmur, IsmailObjectiveThis study was performed to evaluate the efficacy and safety of dextranomer/cross-linked hyaluronic acid (Hyadex) in patients with a clinical diagnosis of vesicoureteral reflux (VUR).MethodsIn this cross-sectional multicenter observational study, Hyadex was used in four different centers for the endoscopic treatment of VUR from 2020 to 2022. The study involved 74 patients (93 renal units) who were diagnosed with VUR according to voiding cystourethrography (VCUG) findings and were considered suitable for subureteric endoscopic treatment. The follow-up time (control VCUG time) was 3 months.ResultsIn the VCUG evaluation, grade I VUR was found in 13 renal units, grade II in 23 renal units, grade III in 42 renal units, and grade IV in 12 renal units. The success rates of Hyadex treatment according to the degree of VUR were as follows: 84.6% for grade I, 82.6% for grade II, 71.4% for grade III, and 66.0% for grade IV. No major complications were observed.ConclusionEndoscopic subureteric Hyadex injection had high success rates in appropriately selected patients with VUR and may be used as the first-line treatment for children with VUR.Öğe Evaluation of antioxidant effect of resveratrol on testicular tissue in rats that were exposed to cigarette smoke(Aves, 2011) Soylemez, Haluk; Ugras, Yahya Murat; Beytur, Ali; Oguz, Fatih; Kurus, Meltem; Karabulut, Aysun BayObjective: The aim of this study was to investigate the negative effects of cigarette on testicular biochemistry and histology of rats and to evaluate if resveratrol could alter these effects. Materials and methods: Thirty-two male Wistar Albino rats were divided into 4 grups for an experiment of 6 weeks. Group 1 was used as control; Group 2 was only exposed to cigarette smoke. Group 3 only received intraperitoneal injections of resveratrol (10 mg/kg/day). Group 4 was exposed to both cigarette smoke and resveratrol (10 mg/kg/day). At the end of the experimental period, the rats were sacrified and testes of all rats were removed. Malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels were measured on testicular tissue and histopathologic examination was performed with light microscope. Results: Weight follow-up of rats revealed no significant difference among groups. MDA level was lower in cigarette smoke and resveratrol group than that of only cigarette smoke group. GSH level showed significant decrease in only cigarette smoke group, while GSH level increased in cigarette smoke and resveratrol group. Differences in NO levels were not statisticaly significant among groups. The histological evaluation revealed that Johnsen score which indicates spermatogenesis was significantly lower only in cigarette smoke rats than all other groups. Conclusion: Oxidative stress develops in testis of rats that were exposed to cigarette smoke, and resveratrol has preventive effects on this damage with direct or indirect antioxidant activity.Öğe Evaluation of reproductive and renal toxicity of varenicline in male rats(Mashhad Univ Med Sciences, 2019) Oguz, Fatih; Beytur, Ali; Taslidere, Elif; Parlakpinar, Hakan; Oguz, Hilal Kurnaz; Polat, Alaaddin; Topcu, IbrahimObjective(s): Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats. Materials and Methods: Rats were randomly divided into two groups: control (n=10) and varenicline (n=24). Then, rats in each group were sub-divided equally as acute and chronic groups. The control rats were orally given distilled water only. Varenicline was administrated orally as follows: 1st-3rd days 9 mu g/kg/day, 4th-7th days 9 mu g/kg twice daily, and 8th-90th days 18 mu g/kg twice daily. The rats of acute and chronic groups were sacrificed on the 45th and 90th days, respectively. Some tissue markers related to oxidative stress were measured, and sperm characteristics were observed. Results: In the acute group, varenicline led to a significant decrease in SOD activities in both kidney and testis tissues. In the chronic group, varenicline significantly increased MDA and MPO production, and reduced CAT and GPx levels in the kidneys and testes. Also, SOD and GSH levels significantly decreased in the testes. Moreover, sperm characteristics were negatively affected; histopathological deformation was observed in the testes and kidneys in all groups. Conclusion: This study showed that varenicline could detrimentally affect the kidneys and testes in both acute and chronic term usage. Further studies will provide more insights into the molecular dynamics of this damage.Öğe How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats?(Pagepress Publ, 2018) Kati, Bulent; Oguz, Fatih; Yilmaz, Ismet; Akdemir, Ender; Altintas, Ramazan; Akpolat, Nusret; Taskapan, Mehmet CagatayObjective: Vegetable oils have an important place in our daily diet. This study starts from this point to investigate the effects of canola oil and hazelnut oil in the male reproductive system in rats. Material and methods: 30 male rats were used in this 16-week study. The animals were divided into three groups: the animals in group I served as the control group, while the animals in group II and group III were fed with hazelnut and canola oil, respectively. The testes of all rats were excised for histopathologic evaluation and immunohistochemical (IHC) evaluation with a standard method. Blood samples were obtained for determination of serum hormone levels. Results: No significant differences were noted with respect to behavior or weight among the three groups. Rats in the canola oil group (group III) had higher luteinizing hormone (LH) and higher testosterone levels than rats in the control group. Rats who received hazelnut oil (group II) exhibited similar findings, with these levels being higher than they were in the control group. No statistical differences were shown for histopathology or IHC testosterone antibody levels across all treatment groups. Conclussion: Canola oil was shown to have a greater effect on serum LH and testosterone compared to the control group and the group fed with hazelnut oil. Further investigation is required into how these oils affect serum hormone and sperm activity.Öğe How safe is the monoplanar access technique for percutaneous nephrolithotomy?(Springer, 2013) Oguz, Fatih; Altintas, Ramazan[Abstract Not Available]Öğe THE IMPORTANCE OF ENSTRUMENT TYPE IN PEDIATRIC PERCUTANEOUS NEPHROLITHOTOMY(Mary Ann Liebert, Inc, 2012) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Cimen, Serhan[Abstract Not Available]Öğe The importance of instrument type in paediatric percutaneous nephrolithotomy(Springer, 2014) Altintas, Ramazan; Oguz, Fatih; Tasdemir, Cemal; Beytur, Ali; Cimen, Serhan; Gunes, Ali; Colak, CemilWe reported our experience with percutaneous nephrolithotomy in children and compared the outcomes, including the morbidity and success rates, regarding the instruments of different sizes. One hundred and seventy-three paediatric patients, who underwent percutaneous nephrolithotomy in our clinic between 1999 and 2013, were assessed. According to the size of instruments used during surgery, three different groups were formed and the pre- and postopeartive outcomes were compared between the groups. 76 girls and 97 boys with a mean age of 9.24 (a parts per thousand currency sign17) years were assessed. Stone-free rates were 75.6 % in group 1 (n = 82) using 17 F nephroscope, 79.4 % in group 2 (n = 73) using 24 F nephroscope and 72.2 % in group 3 (n = 18) using 26 F nephroscope. Postoperative fever was seen in four, five and one patient in group 1, 2 and 3, respectively. Urinary infection was seen in one patient in group 1 and four patients in group 2. Mean haematocrit drop and stone burden were significantly lesser in group 1. No significant difference was seen in the duration of nephrostomy and hospitalization between the groups. The success rates obtained in the groups using different instrument types (paediatric or adult) were similar. However, age, weight, height, stone burden and bleeding were significantly lesser in group 1 that used paediatric type of instrument. As the most frequent complication of PNL, bleeding seems to be associated with stone burden, the diameter of dilatation and the calibre of instrument. To decrease the particular complications, paediatric type of instruments are convenient and do not affect the success.Öğe Intracavitary lesion caused by bladder wall stone and mimicking bladder tumor(2019) Topcu; Ibrahim; Oguz, Fatih; Gecit, Ilhan; Akatli, Ayse Nur; Sancaktar, FatihWe present a 28 year-old patient with insidental intramural stone covered by bladder mass. The pathology was rarely seen cystitis glandularis with intestinal metaplasia. During cystoscopy, stone was not seen, we resected the mass than stone was appeared in buried into the wall and removed from the bladder wall. The stone was fragmented with holmium laser. The pathology of the mass was cystitis glandularis with intestinal metaplasia whish is rarely seen and may be malign by the time. We followed up the patient with cystoscopy every 3 months and no recurrens was detected.Öğe Is There a Relationship Between Chronic Periodontitis and Erectile Dysfunction?(Elsevier Sci Ltd, 2013) Oguz, Fatih; Eltas, Abubekir; Beytur, Ali; Akdemir, Ender; Uslu, Mustafa Ozay; Gunes, AliIntroduction. Chronic periodontitis (CP) is characterized with inflammation of the gingival tissues, which causes endothelial dysfunction in different organs. Aim. In this study, we investigated the association of CP with the erectile dysfunction (ED). Methods. The study group included 80 male patients with ED and 82 male patients without ED (control), aged between 30 and 40 years. The International Index of Erectile Function (IIEF) questionnaire was used to assess male sexual function, particularly the presence or absence of ED. Main Outcome Measures. The patients in the study and control groups were statistically compared according to their plaque index (PI), bleeding on probing (BoP), probing depth (PD), and clinical attachment level (CAL). Results. In the non-ED and the ED groups, the mean age was 35.7 +/- 4.8 and 34.9 +/- 4.9 years, respectively. Patients' characteristics including body mass index, household income, and education status were similar in both groups (0.05). Nineteen patients (23%) had severe CP in the non-ED group; 42 patients (53%) had severe CP in the ED group. Logistic regression analysis showed a significantly high association between ED and the severity of CP (odds ratio: 3.29, 95% confidence interval: 1.369.55, P<0.01). The mean values of PI, BoP, and the percentages of sites with PD >4mm and sites with CAL >4mm were significantly higher in the ED group than in the control group (P<0.05). The mean values of PD and CAL were not significantly different in the two groups (0.05). The decayed, missing, filled teeth scores were also significantly higher in the ED group than in the non-ED group (P<0.05). Conclusion. Our results have suggested that CP had a high association with ED in young adults at 3040 years. We think that it will be of benefit to consider periodontal disease as a causative clinical condition of ED in such patients. Ouz F, Eltas A, Beytur A, and Akdemir E. Is there a relationship between chronic periodontitis and erectile dysfunction? J Sex Med 2013;10:838843.Öğe Long-term effects of percutaneous nephrolithotomy on renal morphology and arterial vascular resistance as evaluated by color Doppler ultrasonography(Springer, 2006) Kiliç, S. leyman; Altinok, Tayfun; Altunoluk, B. lent; Erdogan, Özg l; Oguz, FatihWe evaluated the long-term effects of percutaneous nephrolithotomy (PNL) on renal morphology and vascular resistance. Parenchyma thickness, echogenicity and resistive index (RI) of upper, middle and lower poles of operated and contralateral kidneys of 41 patients with 82 renal units who underwent unilateral PNL with single pole access between 2000 and 2002 were examined separately by color Doppler ultrasonography. Mean patient age and duration between PNL and evaluation time were 38.29 +/- 11.53 years and 46.44 +/- 10.9 months, respectively. In operated kidney, mean RI, parenchyma thickness and echogenicity of the access pole were not statistically different than those of the adjacent two poles (0.608 +/- 0.053 vs. 0.608 +/- 0.052 for RI, P=0.895; 11.46 +/- 2.58 vs. 11.41 +/- 2.68 mm for parenchyma thickness, P=0.838; 0.049 +/- 0.31 vs. 0.073 +/- 0.33 for parenchyma echogenicity, P=0.160, respectively). Although mean RI and parenchyma thickness of access pole were statistically significantly different than the mean values of contralateral kidney (0.562 +/- 0.032 and 14.31 +/- 1.37 mm, respectively), no statistical difference was found between mean parenchyma echogenicities of both of them (echogenicity of contralateral kidney was 0, P=0.317). No significant difference was found between the average echogenicities of the three poles of the operated and contralateral kidneys (0.063 +/- 0.32 vs. 0, P=0.080). In 14 patients RI decreased from 0.694 +/- 0.058 to 0.602 +/- 0.056 in operated kidney (P=0.001) and from 0.604 +/- 0.06 to 0.559 +/- 0.031 in contralateral kidney (P=0.018) following PNL. It seems that PNL does not cause renal scarring, renal parenchymal loss or increase in renal vascular resistance in the long term. However, prospective studies must be performed for more definitive conclusions.Öğe Minimally invasive approaches and their efficacy in pediatric urolithiasis(Aves, 2013) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Cimen, Serhan; Akdemir, Ender; Gunes, AliObjective: We compared the frequency of usage and success of minimally invasive approaches in the management of pediatric urolithiasis in our clinic. Material and methods: Data from pediatric patients (<= 16 years of age) who had undergone percutaneous nephrolithotomy (PNL), ureterorenoscopy (URS), and extracorporeal shock wave lithotripsy (ESWL) between January 2001 and December 2011 were retrospectively investigated. Results: In this study, 415 pediatric patients, who were treated for 291 renal, and 124 ureteral stones, were evaluated. The patients were treated with PNL (n=148; 82 boys, 66 girls), URS (n=99; 58 boys, and 41 girls) or ESWL (n=168; 91 boys, and 77 girls). The mean patient ages were 7.3 (1-16), 9.1 (1-16), and 8.8 (1-16) years in the PNL, URS, and ESWL groups, respectively. The stone-free rates after treatment with PNL, URS, and ESWL were 77, 83.8 and 88.7%, respectively. Conclusion: It is important that selected therapies are properly planned, and the use of minimally invasive approaches is important in pediatric patients due to potentially high recurrence rates. Currently, ESWL, PNL and URS are performed with high success rates for the treatment of stones, and open surgery is rarely used due to the success obtained with minimally invasive approaches.Öğe Montelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male rats(Springer, 2012) Beytur, Ali; Ciftci, Osman; Oguz, Fatih; Oguzturk, Hakan; Yilmaz, FethiIn the current study, the protective effect of montelukast (ML) on cisplatin induced reproductive toxicity in rats was investigated. Twenty-eight rats were equally divided into four groups; first group was kept as control. In the second group, ML was orally administered at the dose of 10 mg/kg/day for 10 days. In the third group, CP was intraperitoneally administered at the dose of 7 mg/kg a single injection, and in fourth group, CP and ML were given together at the same doses. Although CP induced oxidative stress via significant increase in the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx, and SOD in rats. In contrast, ML prevents these effects of CP through cause an increase in GSH, CAT, GPx, and SOD levels and a decrease in formation of TBARS. In addition, sperm motility and serum testosterone levels significantly decrease and histopathological damage increases with CP treatment. However, the effects of CP on sperm motility, serum testosterone level, oxidative and histopathological changes are eliminated by ML treatment. In conclusion, the current study demonstrated that the reproductive toxicity caused by CP may be prevented by ML treatment. Thus, it was judged that co-administration of ML with CP may be useful to attenuate the negative effects of CP on male reproductive system.
