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Öğe Does Body Mass Index Affect Stem Cell Yield in Healthy Donors?(Cig Media Group, Lp, 2025) Hatipoglu, Ugur; Yilmaz, Seda; Okumus, Nazik; Seyhan, Mert; Seyhan, Rasim; Korkmaz, Gulten; Erkurt, Mehmet Ali[No abstract available]Öğe Does body mass index affect stem cell yield in healthy donors?(Pergamon-Elsevier Science Ltd, 2025) Yilmaz, Seda; Okumus, Nazik; Seyhan, Mert; Sahin, Rasim; Korkmaz, Gulten; Erkurt, Mehmet Ali; Namdaroglu, SinemObjectives: Hematopoietic stem cell transplantation is an important treatment for many benign and malignant diseases. Factors affecting the donor response to mobilization and thus hematopoietic progenitor cell yield have been investigated, but studies on donor body mass index are limited and contradictory. Our aim in our study was to investigate this situation. Material and methods: The data of a total of 665 healthy donors were analyzed and divided into 2 groups as body mass index (BMI) < 25 (group 1, n: 247) and >= 25 kg/m(2) (group 2, n: 418). In addition to demographic data, smoking, blood group, agent used for mobilization, number of days of apheresis, volume of blood processed, amount of product collected, complete blood count before mobilization and biochemical parameters were evaluated. Results: Group 1 consisted of 247 and group 2 consisted of 418 participants. Median age was 29 (18-66) years in group 1 and 37 (18-68) years in group 2. Median BMI was 22.49 (16.10-24.98) and 28.06 (25.00-48.27) kg/m(2), respectively. Male donors constituted 62.7 % in group 1 and 73.9 % in group 2. In group 2, the number of apheresis days was lower and the median CD34(+) stem cell count on the first day and in total was statistically significantly higher (7.1 x10(6)/kg and 7.58 x10(6)/kg, respectively). Conclusion: In healthy donors, CD34(+) stem cells were correlated with BMI, whereas no statistically significant difference was found between the groups in terms of smoking habit, blood group, granulocyte stimulating agent type, processed blood volume, non-lymphocyte and biochemical parameters other than LDH.Öğe Is there a relationship between vitamin D levels and graft versus host disease?(Pergamon-Elsevier Science Ltd, 2025) Yigenoglu, Tugce Nur; Ulu, Bahar Uncu; Namdaroglu, Sinem; Erkurt, Mehmet Ali; Sahin, Rasim; Okumus, Nazik; Yilmaz, SedaObjective: Vitamin D deficiency is common in adult patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT). Since vitamin D is an important regulatory factor for the immune system, vitamin D deficiency may have effects on antitumor activity, relapse rates, graft versus host disease (GVHD) occurrence and infection rates in allo-HSCT. We aimed to investigate the effects of vitamin D levels on the outcome of allo-HSCT. Material and methods: This study included 211 patients who underwent allo-HSCT at seven transplant centers in T & uuml;rkiye. The impact of pretransplant vitamin D level on overall survival (OS), relapse rate, GVHD occurrence and engraftment times was analyzed retrospectively Results: Pretransplant vitamin D levels were not related to the neutrophil engraftment day (p: 0.887), relapse rate (p: 0.433) and GVHD occurrence (p: 0.391). At a median follow-up of 14 months, OS was 84.8 % and median OS was not reached. Univariate Cox Regression analysis showed that higher levels of vitamin D (>12 ng/mL) affected the survival rates (p = 0.029) (HR: 0.392: 95 % CI: 10.170-0.907). Conclusion: In our study, pretransplant vitamin D levels were not related to GVHD occurrence, relapse rate and engraftment times. However, we found that higher levels of pretransplant vitamin D levels (threshold is 12 ng/ mL) were associated with increased survival. Further studies with a larger population are necessary to reveal the role of vitamin D in patients undergoing allo-HSCT.Öğe The effect of threosulfan-based versus busulfan-based preparation regimens on transplant outcomes(Pergamon-Elsevier Science Ltd, 2025) Candir, Burcu Aslan; Okumus, Nazik; Hindilerden, Ipek Yonal; Erkurt, Mehmet Ali; Namdaroglu, Sinem; Merter, Mustafa; Yilmaz, SedaBackground: Allogeneic hematopoietic stem cell transplantation is a curative therapy for malignant and nonmalignant hematologic disorders. Conditioning regimens, such as those based on busulfan, are utilized to promote engraftment. Busulfan-based regimens are commonly employed but exhibit significant toxicity, leading to interest in alternate drugs such as treosulfan, which may offer a superior safety profile while preserving efficacy. Methods: This retrospective study examined 240 adult patients diagnosed with acute myeloid leukemia or acute lymphoblastic leukemia who received allogeneic hematopoietic stem cell transplantation at nine transplantation centers in T & uuml;rkiye from 2010 to 2024. Patients underwent either a busulfan-based or treosulfan-based conditioning regimen. Results: Engraftment was effective in both groups, with neutrophil engraftment happening earlier in the busulfan group (13 days vs. 15 days, p = 0.001). The incidence of veno-occlusive disease was significantly higher in the busulfan group (10.1 % vs. 0.9 %, p = 0.002). Cytomegalovirus infections were more prevalent in the busulfan group (51.2 % vs. 26.1 %, p < 0.001). Acute graft versus host disease occurred more frequently in the busulfan group (27.9 % vs. 18.9 %, p = 0.128); nonetheless, this difference did not reach statistical significance. No significant differences in relapse rates were detected through the groups. The overall survival was not reached in the busulfan group, while the treosulfan group demonstrated an overall survival of 40 months. Conclusion: Treosulfan-based conditioning regimens demonstrate similar efficacy to busulfan-based regimens while presenting a more acceptable toxicity profile. Treosulfan-based regimens also show a lower occurrence of veno-occlusive disease and cytomegalovirus infections.
