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    COVID-19 is more dangerous for older people and its severity is increasing: a case-control study
    (Wolters Kluwer Medknow Publications, 2022) Mertoglu, Cuma; Huyut, Mehmet Tahir; Olmez, Hasan; Tosun, Mustafa; Kantarci, Mecit; Coban, Taha Abdulkadir
    Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.
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    The relationship between asthma and eating disorders
    (2020) Arslan Isik, Nurten; Olmez, Hasan
    Obesity is a common comorbidity in asthma and obesity not only causes asthma development, but also leads to weaker asthma control and higher asthma severity. The relationship between obesity and asthma is similar to the relationship between chicken and egg. Obesity can be confusing in the diagnosis and management of asthma. Obesity in asthmatic patients causes overdiagnosis, misdiagnosis, or less diagnosis. The association of asthma and obesity has increased especially due to western type nutrition and sedentary lifestyle. Patients with obesity and asthma as a result of increased inflammatory mediators bronchoconstruction, adversely affected by lung mechanics, increased alveolar-arterial gradient, ventilation-perfusion imbalance, decreased lung volume, asthma disease and other comorbid conditions such as increased comorbid conditions, such as more frequent causes of dyspnea. They are very symptomatic, presenting more in these patients and the quality of life of these patients is worse. Another problem encountered in obese asthmatic patients is their resistance to inhaled steroids, β2-agonists and leukotrene antagonists used in asthma. Conflicting results have been obtained in studies of the effect of asthma on obesity. It is generally accepted that the development of obesity is more common in asthmatic patients due to decreased physical activity. Applying a personalized treatment plan to treat asthmatic and obese patients and applying realistic treatment methods can help the patient lose weight. In addition, obese asthmatic patients should have more symptomatic perception, obesity causes changes in lung function and obese individuals should be aware of the confusing effects of different comorbidities.