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    Investigation of fetomaternal consequences of placental chorangiosis in women with preeclampsia
    (2021) Alci, Mesut; Gunenc, Oguzhan; Omeroglu, Ethem
    Aim: This study aimed to investigate of fetomaternal consequences of placental chorangiosis in preeclamptic and normal pregnant women. Materials and Methods: The study population for this retrospective case-control study was consist of 183 pregnant women (91 pregnant women with preeclampsia and 92 healthy pregnant women). The data on the pregnant women and their infants were obtained from their records; additionally, the placental data were obtained by the histopathological examination of placental samples. Chorangiosis is a vascular hyperplastic process in terminal chorionic villi; that >10 capillary vessels in at least 10 villi of the placenta is called chorangiosis. Results: The case and control groups were similar in terms of their age, gravida, parity, and living and abortion characteristics. The prevalence of chorangiosis, necrosis, and fibrotic villus was high in the placenta of preeclamptic pregnant women; also, their blood values were impaired, and the hospitalization period was longer. Furthermore, the weights and APGAR scores of the infants were low, and the mortality and hospitalization rates were significantly higher. Hence, the presence of preeclampsia and chorangiosis is an important risk factor for the health of both infants and mothers. Conclusion: Although chorangiosis was directly related to negative maternal and fetal outcomes in pregnant women with preeclampsia, more clinical studies with different perspectives are required because chorangiosis was observed in healthy pregnant women as well.
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    Our sentinel lymph node experience in patients diagnosed with DCIS and microinvasive breast carcinoma
    (2021) Bayramoglu, Zeynep; Omeroglu, Ethem; Koksal, Hande; Eryilmaz, Mehmet Ali; Unlu, Yasar
    Aim: Along with the increased availability of radiologic imaging methods, early identification of tumor tissue, and patient surveillance programs; ductal carcinoma in situ (DCIS) and microinvasive DCIS became more commonly identified in the tru-cut biopsy specimens and resected samples of patients. Pathological examinations of the excision materials from these patients reveal invasive tumors, microinvasions or DCIS alone. Recently, it has become debatable whether to perform a sentinel lymph node biopsy (SLNB) in patients diagnosed with DCIS or microinvasive DCIS. In this present study, we evaluated the diagnosis made by examining the excision material, any presence of lymph node metastases, and the relationship of hormone profile to the presence of metastases in the patients diagnosed with DCIS or microinvasive DCIS by the examination of tru-cut biopsy specimens. Based on our study results, we discussed the requirement for SLNB in patients with a tru-cut diagnosis of DCIS or microinvasive DCIS. Materials and Methods: The study included 172 patients, who underwent surgical excision and SLNB after receiving a tru-cut biopsy diagnosis of DCIS and microinvasive DCIS in our hospital from the year 2010 to 2018. Results: Tru-cut biopsy diagnoses were DCIS and microinvasive DCIS in 69.8% (120 patients) and 30.2% (52 patients) respectively. SLNB metastases were identified in 35.8% (n=43) of the DCIS positive patients and 44.2% (n=23) in the microinvasive DCIS positive patients. The diagnosis of invasive ductal carcinoma after mastectomy was made at a rate of 90.0% (n=108) among the DCIS positive patients and 92.3% (n=48) among the microinvasive DCIS positive patients. Conclusion: SLNB metastases were found in 35.8% (n=43) and 44.2% (n=23) of the DCIS positive patients and microinvasive DCIS positive patients, respectively. We conclude that SLNB should be favorably proper to perform in the patients with tru-cut diagnoses of DCIS and microinvasive DCIS because a high rate of SLNB metastases was detected in our DCIS and microinvasive DCIS patients and a high rate of invasive ductal carcinoma diagnosis was made after examining the excision material of these patients.
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    What GATA-3 told us in breast carcinoma? 2 Years of single tertiary center experience
    (2021) Ugur Kilinc, Ayse Nur; Omeroglu, Ethem; Bayramoglu, Zeynep; Unlu, Yasar
    Aim: Our study aims to find the relationship between the degree of GATA-3 expression in breast cancer and other prognostic factors such as ER, PR, HER-2, Ki67, and axillary metastasis. Materials and Methods: The cases in which GATA-3 immunohistochemical staining was applied to breast cancer tissues between 2018 and 2020 were detected. Immunohistochemically stained preparations of ER, PRG, GATA-3, Ki-67, and HER-2 of these cases were obtained from the hospital archive and evaluated by two pathologists. Results: As a result, GATA-3 was directly proportional to PR and ER and inversely proportional to Ki 67. GATA-3 expression was associated with a higher Ki-67 mitotic index compared to the percentage of ER and PR expression. Conclusion: According to the results of our study, indicating GATA-3 positivity and negativity as well as the degree of expression in the pathology reports of breast tumors will help the clinician in terms of differentiation and prognosis of the tumor. Finally, breast tumors with high GATA-3 loss should be evaluated as more primitive tumors and the patients with these tumors should be followed up more closely.