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    Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behget Disease
    (Wiley, 2014) Tasolar, Hakan; Tasolar, Sevgi; Kurtulus, Duygu; Altun, Burak; Bayramoglu, Adil; Omur, Yilmaz; Balli, Mehmet
    Objectives-Owing to the fact that the potential frequency of endothelial dysfunction and early atherosclerosis might be higher in Behcet disease, characterized by acute and chronic inflammatory attacks, it may lead to impairment in flow-mediated dilatation and an increase in epicardial adipose tissue thickness. Therefore, we aimed to evaluate whether epicardial adipose tissue thickness and brachial artery flow-mediated dilatation as markers of early atherosclerosis and endothelial dysfunction were associated with Behcet disease. Methods-Thirty-five patients with Behcet disease and 35 healthy volunteers were included in this study. Epicardial adipose tissue was identified as an anechoic space between epicardial layers on 2-dimensional images, and its thickness was measured on the free wall of the right ventricle. Right brachial artery flow-mediated dilatation was assessed according to recent guidelines. Results-Serum gamma-glutamyl transferase (GGT) levels and epicardial adipose tissue thickness were significantly higher (P = .001; P < .001 respectively), whereas flow-mediated, endothelium-dependent dilatation was significantly lower in the Behcet disease group than controls. (P < .001). There was a significant negative association between epicardial adipose tissue thickness and flow-mediated dilatation (P < .001). Epicardial adipose tissue thickness was also positively correlated with Behcet disease activity (P < .001), Behcet disease duration (P < .001), and waist circumference (P < .001). Flow-mediated dilatation was negatively correlated with GGT (P < .001), Behcet disease activity (P < .001), and age (P < .001). There was also a significant association between GGT and Behcet disease activity (P < .001). Conclusions-We found that epicardial adipose tissue thickness was significantly higher and flow-mediated dilatation was significantly lower in patients with Behcet disease than in controls. We suggest that identification of increased epicardial adipose tissue might aid in the diagnosis and treatment of possible coronary artery disease in patients with Behcet disease.
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    Protective effects of melatonin against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cardiac injury in rats
    (Elsevier, 2015) Ediz, Sarihan Mehmet; Hakan, Parlakpinar; Osman, Ciftci; Fethi, Yilmaz; Mustafa, Sagir; Omur, Yilmaz; Gokhan, Ceker
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the prototype of a group of highly toxic environmental chemicals. Although there are some suggestions regarding TCDD-induced cardio-toxicity, the exact mechanisms underlying this process have not been fully discovered. One mechanism related to this toxicity is believed to be the generation of reactive oxygen species. Melatonin is known to be a strong antioxidant and has a free radical scavenging ability. Therefore, the aim of this study was to investigate the TCDD-induced cardio-toxicity and the protective effects of melatonin in rats. Rats were randomly divided into 4 equal groups (n = 7 for each group). Group 1 was control; group 2 was TCDD group (2 mu g/kg/week, p.o); group 3 was melatonin group (5 mg/kg/day, i.p.) and group 4 was TCDD and melatonin treatment group. All agents were continued to be administered until the 45th day. Body/heart weights, mean oxygen saturation (PO2%), hemodynamic [mean blood pressure (MBP) and heart rate (HR) from the cannulated-carotid artery] and electrocardiographic evaluations (arrhythmias and duration of PR, QRS and QT intervals), biochemical and histopathological analysis were carried out TCDD exposure caused significant body and heart weight loss, impairment of PO2%, and decrease of MBP and HR levels. Also, major ECG changes and prolongation of PR, QRS and QT durations were observed in TCDD-exposed rats. In biochemical analysis, TCDD significantly induced lipid peroxidation and reduced antioxidant activities. Moreover, our histopathological observations were in accordance with the biochemical results. According to the results, melatonin treatment significantly protected the subjects from TCDD-induced cardio-toxicity. (C) 2015 Elsevier B.V. All rights reserved.