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Öğe Association of Betatrophin, TNF-α and IL-6 with diabetic microvascular and macrovascular complications(2020) Gozel, Nevzat; Burkay Yakar, Elif Melek; Onalan, Erhan; Gursu, FeritAim: The most important goal in the treatment of Diabetes Mellitus is to protect patients from micro and macro complications. Inflammatory cytokines and betatrophin have been reported to play a role in diabetic micro and macro complications. This study aimed to investigate the effect of serum Betatrophin, TNF-α and IL-6 levels on diabetic micro and macro complications in patients with type 2 Diabetes Mellitus.Öğe Effects of Vitamin D on adropine and apoptosis in kidney tissue(2019) Onalan, Erhan; Demircan, Selcuk; Aydin, Suleyman; Kuloglu, Tuncay; Yalcin, Mehmet Hanifi; Gozel, Nevzat; Donder, EmirAim: This study aims to investigate the effects of vitamin D on adropin and apoptosis in rat kidney tissue in the context of the experimental diabetes model created using streptozotocin (STZ).Material and Methods: 41 male Wistar-albino breed rats of 8-10 weeks were distributed into 5 groups, which consisted of 3 groups with 7 animals each and 2 groups with 10 animals each. No treatments were applied to the control group. The Buffer group was administered with single-dose 0.1 M sodium buffer intraperitoneally (ip). The Vitamin D group was orally administered 200 IU/day vitamin D. The Diabetes group was injected ip with single-dose 50 mg/kg STZ by dissolving the material in 0.1 M sodium buffer.Results: The biochemical and histological investigations revealed similar serum TOS and TAS levels, and TUNEL positivity and Adropin immunoreactivity for the Control, Buffer, and Vitamin D groups. While TOS levels and TUNEL positivity were significantly higher in the Diabetes group compared to the Control group, TAS levels and Adropin immunoreactivity were significantly lower. The TOS levels and TUNEL positivity were significantly reduced in the Diabetes+Vitamin D group compared to the diabetic group, and TAS levels, adropin immunoreactivity were significantly higher. Conclusion: In conclusion; it was determined that experimental diabetes increased TOS and apoptotic cells and decreased TAS and adropin levels in the kidney tissue in experimental diabetes, and that Vitamin D administered as treatment decreased TOS and apoptotic cells and increased TAS and Adropin levels. It was concluded that in order to uncover the role of diabetes in the pathophysiology of its effect on kidney tissue, future studies that consider various experimental diabetes times were necessary.Öğe Prevalence of vitamin D deficiency in patients with type 2 diabetes and its relationship with glycemic control(2019) Onalan, Erhan; Gozel, NevzatAim: The aim of our study is to investigate serum 25-hyrdoxy (OH) vitamin D levels in patients with type 2 diabetes, determine the prevalence of vitamin D deficiency, and reveal the potential relationship between vitamin D deficiency and glycemic control. Material and Methods: A total of 100 patients (50 females, 50 males) diagnosed with type 2 DM were included in the study. Data used in the study were retrospectively acquired from the records in the files of patients who had presented to the General Internal Medicine polyclinic and clinic at Firat University Hospital. Results: Mean vitamin D levels were determined as 11.8 ± 5,8 nmol/l in females and 13.5 ± 7.3 nmol/l in males. 57 patients (57%) in total demonstrated vitamin D deficiency. Vitamin D deficiency was detected in 31 (62%) female patients and 26 (52%) male patients. A significant negative correlation was determined between diabetic patients with and without vitamin D deficiency with regard to HbA1c, fasting blood glucose, post-prandial blood glucose (p<0.001). Diabetic patients with vitamin D deficiency and diabetic patients without vitamin D deficiency demonstrated no significant differences with regard to retinopathy, nephropathy, and neuropathy (p>0.05).A significant negative correlation was determined between diabetic patients with and without vitamin D deficiency with regard to BMI and patient weight (p<0.001). Conclusion: Our study concludes that vitamin D has a negative significant correlation with FBG, PPBG, HbA1C, and BMI. These results indicate that, as vitamin D levels decrease in patients with type 2 diabetes, insulin resistance increases, and consequently, glycemic control is disrupted. Although, along with our study, other studies too have reported an increased risk for Type 2 diabetes in the presence of vitamin D deficiency, evidence suggesting a causal relationship is limited as not an adequate number of high-quality randomized controlled studies exist.Öğe The relationship between betatrophin levels and HbA1c(2020) Kilicoglu, Mesut; Solmaz, Ihsan; Yakar, Burkay; Onalan, Erhan; Gursu, FeritAim: In our study, we first aimed to investigate the effect of betatrophin in uncontroled diabetes patients with HbA1c above 14. Another focus of our study is the effect of betatrophin levels on the biochemical parameters of the patients. Material and Methods: This is an observational study with a prospective case-control design. The study was carried out between July 2018 and November 2018 at the internal medicine clinic of the tertiary university hospital. Our study was conducted with participants divided into 3 groups. Group 3 (uncontrolled T2DM) consisted of 40 participants who met the study criteria and HbA1c above 14% . Group 2 (controlled T2DM) consisted of 40 participants who met the study criteria and HbA1c below %10 and the group 1 (control group) consisted of 40 people who did not have a history of diabetes mellitus.Results: There was no statistical difference in age and sex between the 3 groups included in the study. Betatrophin levels of patients with uncontrolled diabetes were significantly higher than control group and controlled diabetic group.(p0.001). HbA1c value of the participants was found to have a significant effect on betatrophin level, unlike other parameters.(p0.001).Conclusion: We found higher betatrophin levels in the group with uncontrolled diabetes in our study. There was no significant difference in betatrophin levels between the controlled T2DM group and the healthy group. Our data found that betatrophin level showed a significant positive correlation with HbA1c level.
