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  • Küçük Resim Yok
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    Nature-derived otolith loaded polyethylene glycol-polycaprolactone electrospun composite nanofiber membranes: preparation, characterization, and biocompatibility evaluation
    (Springer, 2025) Pekdemir, Sibel Selcuk; Gedik, Kubra Karadas; Kurucay, Ali; Onay, Hatice; Ulu, Ahmet; Pekdemir, Mustafa Ersin; Kolak, Seda
    The electrospun nanofibers have paid much attention to biomedical applications. In this study, the electrospun composite nanofibers were prepared based on optimized polycaprolactone (PCL, 12 wt%) and polyethylene glycol (PEG, 3.6 wt%) polymers loaded with otoliths particles (OTO, 10-30 wt%) by electrospinning technique. The morphological, molecular interactions, crystallinity, and thermal properties of the composite nanofiber membranes were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry. In addition to that, swelling behaviors, biodegradability, porosity, and biocompatibility were also evaluated. Both PEG/PCL and OTO/PEG/PCL nanofibers revealed bead-less constructions with average diameters of around 500 nm. Thermogravimetric analysis revealed OTO/PEG/PCL composite membranes thermally stable up to 300 degrees C. XRD results also indicated a good crystallinity for the OTO/PEG/PCL composite membranes due to higher crystallinity of otolith. Adding otolith to PEG/PCL nanofibers did not obviously change the water uptake capacity, biodegradability, and porosity while increasing swelling ratio. Finally, membranes with the lowest otolith concentration (10% w/w) showed 96.2% cell viability, while increasing otolith concentration decreased cell viability. Based on the obtained results, the cytotoxicity of OTO/PEG/PCL membranes was evaluated with mouse fibroblast (L-929) cells by more than 85% survival during 72 h, which revealed that the OTO/PEG/PCL membranes were non-toxic. Taken together, these data suggest that OTO/PEG/PCL membranes could potentially be used as a nanofiber scaffold for applications.
  • Küçük Resim Yok
    Öğe
    Valorization of bio-calcium carbonate based Chamelea gallina shell waste fillers in shape memory polymer composites
    (Wiley, 2024) Pekdemir, Sibel Selcuk; Onay, Hatice; Oner, Ecem Ozen; Pekdemir, Mustafa Ersin; Kok, Mediha; Ates, Burhan; Aydogdu, Yildirim
    In recent years, the focus has been on the use of calcium carbonate-based seashell wastes in the production of new thermoplastic and thermoset polymer materials, paving the way for their use as biofillers in polymeric composites. In this study, it is aimed to obtain a new polymeric composite material by doping Chamelea gallina shells, on polylactic acid (PLA)/polyethylene glycol (PEG) blend. Structural characterization of the obtained PLA/PEG blend/C. gallina composite films was performed with attenuated total reflection infrared spectroscopy (ATR-IR). When the thermal properties of composite materials were examined by thermogravimetric analysis (TGA), it was determined that the thermal stability of polymeric composites increased with the addition of C. gallina. SEM images showed that the polymer blend films, which appeared to have a porous structure, filled the pores with increasing C. gallina ratio. It was observed that the biodegradability of PLA/PEG blend composite films decreased with increasing C. gallina shells addition. However, C. gallina had a positive effect on the swelling and water absorption capacities of polymeric composites. The increase in tensile strength and elongation at break values of PLA/PEG blend/C. gallina composite films with increasing C. gallina means that the mechanical properties of the polymer are improved.