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    Annular lichen planus of the eyelid: A rare entity
    (2020) Ayhan, Erhan; Bulut, Ecem; Akman, Zehra; Dere, Gokturk; Onder, Sevda
    Lichen planus (LP) is a common inflammatory dermatosis. Annular LP affecting the only eyelid, however, has rarely been reported. Diagnosis of annular LP limited to the eyelid can be a real challenge. We report a case of annular LP limited to the eyelid with its clinical, dermoscopic and histopathological findings.
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    Assessment of BCL-2 expression in actinic keratosis, keratoacanthoma and seborrheic keratosis cases
    (2019) Onder, Sevda; Erdem, Havva; Turhan Haktanir, Nurten; Balta, Hilal; Akcay Celik, Muruvvet
    Aim: One of the main functions of apoptosis is the elimination of cells with damaged DNA, including premalignant cells in skin. Apoptosis is regulated by the balance between antiapoptotic and proapoptotic proteins. The bcl–2 protein has been shown antiapoptotic effect. It protects cell against apoptosis induced by different death-inducing signals. Material and Methods: In this study the authors have analyzed imunohistochemically the expression of bcl-2 protein in the histopathological variants of the precancerous lesion [actinic keratosis (AK) (28 cases) and keratoacanthomas (KA) (12 cases) and seborrheic keratosis (SK) (22 cases) in skin. Results: In cases of AK, bcl-2 expression was confined to basal cell layer, as well as in two cases of thorough epidermis. SK expression of bcl–2 protein was in areas of basaloid proliferation.KA expression of bcl-2 protein was not dome-shaped keratin-filled crater areas but bcl-2 expression was confined of non crater areas. Conclusion: In conclusion, bcl-2 expression supports the observation that tumor cells are derived from basal keratinocytes in AK and SK and not support the observation that tumor cells are derived from basal keratinocytes in KA.
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    Evaluation of cardiometabolic function with serum adropin levels in psoriasis patients
    (2021) Onder, Sevda; Bayrak, Tulin; Kaya, Yasemin; Cankaya, Soner; Ozturk, Murat
    Aim: Psoriasis is a skin disease with metabolic and cardiac comorbidities. Adropin is a peptide hormone which is thought to play a role in metabolic diseases, energy homeostasis, endothelial function and cardiac diseases in recent years. In this study, we aimed to evaluate adropin levels in psoriasis patients Materials and Methods: The study included 51 plaque psoriasis patients aged 18-65 years who had no systemic disease and had not received systemic treatment in the last three months and 37 healthy controls matched by sex, age and body mass index (BMI). Serum adropin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG), fasting blood glucose (FBG), fasting serum insulin, BMI, systolic blood pressure (SBP) and diastolic blood pressure (DBP) values were recorded. Results: Serum adropin level was 73.04 ± 46.21 pg / ml in the patient group. In the control group, serum adropin level was 77.26 ± 43.69 pg / ml. Serum adropin levels were lower in the patient group, but this was not statistically significant (p = 0.667). PASI value was negatively correlated with serum adropin level. There was no correlation between serum adropin level and other variables. Insulin level, Homa-IR level, systolic and diastolic pressure were significantly higher in the patient group (p <0.05). Conclusion: In our study, although adropin levels were not significantly lower in the patient group, we concluded that this may be associated with low PASI values. The role of adropin in psoriasis vulgaris will emerge with further studies.