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    Evaluation of socio-demographic characteristics of people was determined to use synthetic cannabinoids in Malatya and its surrounding cities / districts and LC-MS/MS analysis method
    (2020) Oruc, Mucahit; Petekkaya, Semih; Soylu, Ozcan; Oner, Bedirhan Sezer; Celbis, Osman; Dinc, Ahmet Hakan
    Aim: Synthetic cannabinoids (SC) were initially developed in 1960s to target the cannabinoid receptors in medical therapy. However, in recent years, the developed SC derivatives by processing the plant-based material have been sold on websites under the name of natural drugs.The city of Malatya is located at the eastern part of Turkey and has an important location for the transfer and marketing of narcotic substances. In our study, presentation of the socio-demographic characteristics of the cases, the SC was determined in whose blood samples in the analyses, living in Malatya and the surrounding cities-districts were aimed.Materials and Methods: In the scope of study, 275 cases whose blood samples was sent to the Chemistry Department in Forensic Medicine Institute at Malatya Group Presidency in 2016 and were detected as SC-positive by the chemical analysis were investigated.Results: Out of 275 cases, 97.8% were male, 2.2% were female. Median age was 24, 66.5% (n=180) of them were primary school, 18% (n=51) were high school graduate and 0.7% (n=2) were university graduate. The educational status of 27 cases could not be obtained.Conclusion: SC derivatives are marketed with slogan of “the natural ones are harmless”, and their use among the young people is rapidly becoming widespread. In our study, it was determined that the SC users are in the young age group and have low educational status. In order to decrease the number of users, awareness meetings regarding the harmful effects of SC must be organized in the educational institutions.
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    Sudden death in relation to inhaling lighter fluid in adolescents
    (Romanian Legal Med Soc, 2017) Bork, Turgay; Celbis, Osman; Petekkaya, Semih; Oner, Bedirhan Sezer; Samdanci, Emine
    Background. Sudden death as a consequence of lighter fluid abuse, though rare, happens during the adolescence period. The purpose of this study is to discuss the findings related to the deaths of young adults who died due to inhalation of lighter fluid. Material and Methods. 4 cases who died due to lighter fluid inhalation are included in the study. The autopsy as well as toxicological and pathological procedures of the cases are conducted in Malatya Council of Forensic Sciences. The age, sex, height, weight, clinical findings before death, place of death, autopsy and histopathology findings are assessed in comparison to the toxicological results. Findings. All the cases in the study are male. The ages are 15.75 +/- 1.25, heights are 167.75 +/- 12.68 cm and weights are 58.50 +/- 8.69 kg. In blood analyses, n-butane and isobutane are found in all of them while 3 of them has propane. Besides, 2 of the cases had Tetrahidrocannabinol in their blood and urine. Three of the deaths happened in the hospital while 1 of them was in the crime scene. In the autopsy of the cases, macroscopically, intensive point bleedings are detected while alveolar fresh bleeding centers are found in the histopathology. Conclusion. Autopsy and histopathologic findings are non-specific and the decision shall be given by assessing toxicological findings, crime scene examination and witness statements. In suspicious adolescent death, the detection of propane, isobutane and n-butane in toxicological examination is the only finding that makes us think of the presence of lighter fluid inhalation.
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    The Use of Handwriting Changes for the Follow-up of Patients with Bipolar Disorder
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2022) Ayaz, Nusret; Celbis, Osman; Porgali Zayman, Esra; Karlidag, Rifat; Oner, Bedirhan Sezer
    Introduction: Patients with bipolar disorder have motor skill deficiency and cognitive dysfunction. It is suggested that these deficiencies are related to the neurodevelopmental course of the disease. The aim of this study was to examine whether or not there was a change in the handwriting of patients with bipolar disorder in periods of mania and remission. Method: Two samples of handwriting and signature were taken from the cases, one on admission before treatment and one just after discharge. The first sample was taken in the period when the patients hospitalised with manic episode before medications and the second sample was taken in remission when the decision for discharge was made. The handwriting changes betwen the manic episode and the remission period were examined. Results: In the examination of the handwriting between the two periods. there was an increase in the size of the writing, pen pressure, the length of words, the spaces between words, and missing and incorrect punctuation marks in the manic episode. There were no differences in any handwriting measure on function of the specific diagnosis or the antipsychotic dose but tremor count was higher in patients using antipsychotics (p<0.05). Most of the parameters showing a change were found to be related to the Young Mania Rating Scale (YMRS) scores. Conclusion: The results of this study determined severe changes in the handwriting of patients with bipolar disorder in a period of mania. Handwriting features can be used to screen patients for discharge and can be used for prediction when a patient might switch into manic episode. Also intake YMRS scores were found as the most important feature that affect handwriting parameters in manic patients.