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    Evaluation of IL-32 Levels in Gingival Tissue and Serum of Experimental Periodontitis Model
    (2017) Ongoz Dede, Figen; Balli, Umut; Durmuslar, Mustafa Cenk; Bozkurt Dogan, Seyma; Avci, Bahattin; Ayas, Bulent; Tuncel, Ozgur Korhan
    Aim: Interleukin (IL)-32, a recently discovered proinflammatory cytokine, is demonstrated in several infectious diseases. The goal of this study is to investigate the levels of IL-6, IL-10 and IL-32 in gingival tissue and serum of rats with experimental periodontitis.
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    Induces of periodontitis increases salivary orosomucoid levels
    (2018) Gokmenoglu, Ceren; Ongoz Dede, Figen; Sahin, Ismail Onur
    Aim: Periodontitis is characterized by chronic infection and inflammation in periodontal tissues leading to destruction of dental support tissues. Acute-phase proteins are effective markers for the identification and evaluation of inflammatory diseases including periodontitis. Orosomucoid (ORM) is an acute-phase plasma protein, also called alpha-1-acid glycoprotein, which is inflammation sensitive. The aim of this study was to evaluate and compare the salivary levels of ORM and C-reactive protein (CRP) in individuals with/withoutperiodontal disease. Material and Methods: A total of 90 subjects were divided into two groups of 45 patients each; periodontally healthy and chronic periodontitis. Saliva samples were collected, and clinical periodontal parameters and salivary flow rates were evaluated at baseline. The ORM and CRP levels in the saliva were analyzed with enzyme-linked immunosorbent assay. Results: The periodontal clinical parameters were significantly higher in the chronic periodontitis group when compared to those of the healthy controls (P<0.05). There was no significant difference in the salivary flow rate between the chronic periodontitis and periodontally healthy groups (P>0.05). However, the CRP and ORM levels in the saliva were significantly higher in the chronic periodontitis patients than in the healthy controls (P<0.05). In addition, a significant positive correlation was found between the CRP and ORM levels in saliva of all groups (P<0.05). Conclusions: This study revealed that presence of periodontitis was associated with higher salivary CRP and ORM levels. Moreover, the ORM level seemed to be associated with tissue destruction in inflammatory periodontal disease.
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    Relationship between gingival inflammation and total glutathione
    (2017) Ongoz Dede, Figen; Bozkurt Dogan, Seyma; Balli, Umut; Avci, Bahattin
    Aim: Glutathione, which is known to be the main antioxidant, is the foremost redox regulator in the control of inflammatory processes. The goal of this study was to investigate the levels of total glutathione, which plays a central role in cellular antioxidant defense, in the gingival crevicular fluid (GCF) and plasma of individuals with gingivitis and periodontally healthy.