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Öğe Effects of erythropoietin on renal tissue in an experimental rat model of septic shock(2018) Oter, Serdar; Oter, VolkanAim: To examine the effect of erythropoetin on renal function and histological findings in experimental septic shock model, 24 Sprague-Dawley rats were used. Material and Methods: Rats were divided into control, septic shock, and erythropoetin-treated septic shock groups. Femoral vein and artery catheterization were performed on all rats. Rats in the control group underwent laparotomy and catheterization; in the test groups, cecal ligation-perforation and bladder cannulation were added. Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg erythropoetin 60 minutes after cecal ligation perforation. Rats were monitored for blood pressure, heart rate, and body temperature to assess the postoperative septic response. The body fluids were replaced as necessary. At the end of 24 hours, rats were sacrificed and renal samples were collected. Results: In our study, although there were lessstudies about septic shock model with erythropoietin, we have achieved similar results as the data in the available literatures. WBC, fever, urinary volume, urinary creatinin, BUN, blood creatinin values were significantly better in sepsis treated by erythropoietin group than non-treated sepsis group (p<0,001, table 1)Significant improvements were observed in histological findings in rats treated with erythropoetin, compared to rats with untreated. Discussion: Our findings demonstrate that erythropoetin has antioxidant effects of sepsis as seen in other studies. We conclude that erythropoetin may be an effective treatment for oxidative damage due to renal tissue perfusion defects in cases of septic shock.Öğe The results of perforated peptic ulcer surgery; A single center experience of 86 patients(2018) Oter, Volkan; Yalcin, Metin; Kafadar, Mehmet Tolga; Oter, SerdarAim: At the present time, eradication of the Helicobacter pylori infection is dramatically reduced the risk of the peptic ulcer disease. Whereas, complication rate of the peptic ulcer, such as perforations or bleedings have not been reduced significantly yet. The aim of the current study is to analyze the surgical treatment outcomes of our experiences in 86 patients with peptic ulcer perforation. Material and Methods: Between January 2012 and December 2017, 86 patients who were operated emergently for perforated peptic ulcer disease with Graham’s omental patch procedure in our hospital were included in this study. Demographic, clinical data, diagnostic studies, surgical procedures, operative findings, postoperative complications and patient follow-up were analyzed. Results: The mean age was 41.57±16.09 years. Out of 86 cases there were 65 (75.6%) male patients and 21 (24.4%) female patients. The mean operation time was 66.98±18.61 minutes. The mean hospital stay period was 7.95±2.02. In three months of follow-up period, endoscopy was done to all of these patients and peptic ulcer disease was not seen in any of them. Conclusion: Our findings revealed that Graham’s omental patch repair is still a useful method for perforated peptic ulcer disease. Low complication rates, low duration of hospital stay and also low postoperative morbidity can be achieved with good preoperative and postoperative supportive care in open surgery for peptic ulcer perforation. Laparoscopic surgery should be performed only in the presence of experienced surgeon and also in the presence of sufficient laparoscopic materials.