Yazar "Ozbey, Gurkan" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Investigation of the Relationship Between IL-17, IL-27, IL-2 Blood Levels in Spontaneous Abortion and Healthy Pregnant Women
    (Mdpi, 2025) Ozbey, Gurkan; Tanriverdi, Elif Seren; Cakir, Ayberk; Yilmaz, Ercan
    Background: Cytokines are essential for regulating immune cell activity during pregnancy. Research shows that CD4+ T-cells exhibit specific cytokine secretion patterns, resulting in polarized immune responses. This study aims to compare the gene expression levels of Th1, Th2, and Th17 cytokines in women with normal pregnancies versus those with a history of recurrent spontaneous abortion (RSA). Methods: In this case-control study, 20 patients with RSA within 24 h of their last abortion were compared to 20 pregnant women with no history of abortion (Control Group). Cytokine levels of IL-2, IL-17, and IL-27 were quantified using real-time polymerase chain reaction (RT-PCR). Results: Overall cytokine levels were similar between the groups, but the cytokine levels in both groups were generally similar. However, higher IL-17 and IL-2 levels were observed in the healthy pregnancy group (p = 0.006 and p = 0.001, respectively). Elevated IL-17 and IL-27 levels were observed in healthy pregnancies, whereas lower levels were seen shortly after a miscarriage. IL-27 levels were significantly higher in women with recurrent abortions compared to those with healthy pregnancies (p < 0.001). Conclusions: Elevated IL-2 levels may be a risk factor for RSA. Consistent with recent studies, our findings emphasize the role of IL-17 and IL-27 as crucial regulatory cytokines for maintaining a successful pregnancy.
  • Küçük Resim Yok
    Öğe
    Myoma Uteri
    (2025) Ozbey, Gurkan; Yilmaz, Ercan
    Uterine fibroids, also known as leiomyomas or myoma uteri, are benign smooth muscle tumors that arise primarily in women of reproductive age. These tumors are hormonally responsive, with their growth strongly influenced by estrogen and progesterone. Myomas can be asymptomatic or cause a wide range of clinical manifestations including menorrhagia, anemia, pelvic pressure, urinary disturbances, and infertility. The etiology involves genetic mutations, notably in the mediator complex subunit 12 and high mobility group AT-hook 2 genes, and environmental factors such as exposure to endocrine- disrupting chemicals. Epidemiological studies reveal higher prevalence in African descent and familial aggregation. Diagnosis is often achieved through pelvic examination and ultrasonography, whereas magnetic resonance ımaging remains the gold standard for complex cases. Fibroids are classified using the Federation of Gynecology and Obstetrics system based on their location relative to the endometrial and serosal surfaces. Medical management includes non-steroidal anti-inflammatory drugs, antifibrinolytics, and hormonal therapies, though they primarily target symptoms rather than tumor size. Surgical options such as hysterectomy, myomectomy, and minimally invasive techniques such as magnetic resonance-guided focused ultrasound are indicated for refractory cases. Future directions emphasize early diagnosis, individualized treatment, and the use of fibroids as a model to explore novel therapeutic strategies, particularly those aiming to interrupt fibroid pathogenesis at the molecular level. Given their accessibility and relatively benign nature, fibroids also provide a valuable platform for testing emerging technologies in gynecologic care. As research advances, the paradigm is shifting from radical surgical intervention toward personalized, fertility-preserving treatments.
  • Küçük Resim Yok
    Öğe
    The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium
    (Springer Heidelberg, 2025) Ozbey, Gurkan; Tuncay, Gorkem; Duz, Senem Arda; Cigremis, Yilmaz; Karaer, Abdullah
    Endometrial polyps are hyperplastic overgrowths of the endometrium that contain both glands and stroma. Myoma uteri is the most common benign tumor of the female pelvis and uterus. HOXA10, which is involved during the organogenesis of the uterus in the embryonic period. The aim of this study was to compare the expression levels of infertility-related genes in endometrial tissue obtained from patients with endometrial polyp and myoma uteri and from healthy controls. A total of 36 patients, including 15 women with endometrial polyp and 21 women with myoma uteri, and 23 healthy controls were enrolled in the study. All patients were evaluated using transvaginal ultrasonography. Endometrial tissue samples were collected from the patient and control groups between the 19th and 21st days of the menstrual cycle. Expression levels of the receptivity markers PROK1, PROKR1, PROK2, PROKR2 and HOXA10 genes were determined by RT- PCR. When the patients diagnosed with endometrial polyp and the healthy controls were compared, it was observed statistically significantly that the expression of PROKR1 increased in endometrium tissue of patients with endometrial polyp (p < 0.05). In patients diagnosed with myoma uteri, gene expression levels of endometrial PROKR1 was statistically significant increased and gene expression levels of PROK1, PROKR2, HOXA10 were found to be statistically significantly decreased compared to the controls (p < 0.05). Changes in the endometrial expression of the HOXA10 and prokineticin gene family in patients with myoma uteri and endometrial polyps may explain certain aspects of infertility in these patients.