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    Epidemiological and clinical features of patients with primary antibody deficiency disorders in the East of Turkey
    (2019) Topal, Erdem; Ozbey, Mehmet Yavuz; Aslan, Mehmet
    Aim: To describe the demographic and clinical features of patients diagnosed with primary antibody deficiency Material and Methods: The medical records of pediatric patients who were diagnosed with primary antibody deficiency were reviewed. Patients were diagnosed with primary antibody deficiency based on the European Society for Immunodeficiencies diagnostic criteria. Result: A total of 60 patients with primary antibody deficiency were identified; 39 patients (65%) were male and median age was 5 (1-18) years of age, while median diagnosis age was 3 (6 mo-14 yr) years. Twenty-one patients (35%) were diagnosed with transient hypogammaglobulinemia of infancy, thirteen (21.7%) with selective Ig A deficiency, five (8.3%) with congenital agammaglobulinemia, five (8.3%) with selective Ig M deficiency, five (8.3%) with unclassified hypogammaglobulinemia, four (6.7%) with Ig G subclass deficiency, two (3.3%) with severe combined immune deficiency, two (3.3%) with common variable immunodeficiency, two (3.3%) with hyper Ig M syndrome, and one patient was diagnosed with pneumococcal vaccine responsiveness, respectively. Eleven patients (18.3%) had consanguinity and six patients (10%) had family history. The most common complaint was frequent respiratory tract infections. Four patients had dermatitis in addition to infection. Three patients had hematopoietic stem cell transplantation and 23 patients (38.3%) received intravenous immunoglobulin treatment. Two patients died during the follow up. Conclusion: Our results indicated that diagnosis is delayed and the patients who are diagnosed with primary antibody deficiency frequently have respiratory tract infections.
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    Foreign-body aspiration mimicking asthma in pre-school age group: A case report
    (2019) Ozbey, Mehmet Yavuz; Topal, Erdem; Ulutas, Hakki; Celik, Muhammet Reha
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    Foreign-body aspiration mimicking asthma in pre-school age group: A case report
    (2019) Ozbey, Mehmet Yavuz; Topal, Erdem; Ulutaş, Hakkı; Çelik, Muhammet Reha
    Foreign-body aspiration mimicking asthma in pre-school age group: A case report
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    A rare cause of severe superficial herpetic skin infection in a 13-month-old female patient: Autosomal recessive HIES
    (2018) Arikanoglu, Emrullah; Demirtas, Mehmet Semih; Ozbey, Mehmet Yavuz; Kiykim, Ayca; Topal, Erdem
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    Subcutaneous allergen-specific immunotherapy with Gramineae pollen in children with allergic rhinoconjunctivitis
    (2023) Yılmaz, Ercan; Topal, Erdem; Karagol, Hacer Ilbilge Ertoy; Ozbey, Mehmet Yavuz; Cavkaytar, Ozlem; Arga, Mustafa
    Aim: Patients experiencing persistent complaints of moderate-severe allergic rhinoconjunctivitis despite symptomatic treatment are considered candidates for Allergen Specific Immunotherapy (ASIT). The present study aims to assess the effectiveness and safety of ASIT using Gramineae pollen in children afflicted by allergic rhinoconjunctivitis. Materials and Methods: The study involved participants between 5 and 18 years of age who had allergic rhinoconjunctivitis. These participants were divided into two distinct groups. The initial group underwent ASIT, while the other constituted the control group that refrained from it. The control group comprised participants with akin ages and equivalent disease durations. Visual analog scores (VAS), daily symptom scores (dSS), daily medication scores (dMS), and combined symptom and medication scores (CSMS) were assessed at three specific time junctures: Baseline, post the initial year of ASIT, and after the second year of ASIT. Results: The study encompassed 188 children who had been diagnosed with allergic rhinoconjunctivitis. Among these, 94 patients had undergone immunotherapy. Of the total cases, 105 (55.9%) were male, with a median age of 14 years (range: 7-18 years). Among the patients who had received ASIT, there were statistically significant reductions in VAS, dSS, dMS, and CSMS after one and two years of therapy when compared to the baseline values (p<0.001). Upon comparing the group receiving ASIT with the control group after a two-year follow-up, notable reductions were observed in VAS, dSS, dMS, and CSMS (p<0.001). Five patients (5.3%) experienced systemic reactions. Conclusion: The current study demonstrated that ASIT with Gramineae pollen is clinically effective in patients with Graminae pollen-induced allergic rhinoconjunctivitis.