Yazar "Ozcan, A. Cemal" seçeneğine göre listele

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    The Effect of Agoraphobia on Oxidative Stress in Panic Disorder
    (Korean Neuropsychiatric Assoc, 2013) Gul, Lsil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul Elbozan; Turkoz, Yusuf; Kartalci, Sukru; Ozcan, A. Cemal; Erdemli, M. Erman
    We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAG), paraoxonase (PUN), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAG, PUN, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAG, PUN, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAG, PUN, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
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    The neuropsychological and neurophysiological profile of women with pseudoseizure
    (W B Saunders Co-Elsevier Inc, 2013) Almis, Behice Han; Cumurcu, Birgul Elbozan; Unal, Suheyla; Ozcan, A. Cemal; Aytas, Ozgur
    Objective: Our aim in this study was to compare the assessments of neuropsychological tests and the p50 neurophysiological test of patients with seizure diagnosed as conversion disorder and healthy control subjects, and to investigate the neurological status in conversion disorder with pseudoseizure. Methods: A total of 22 female conversion disorder patients with convulsions diagnosed according to SCID-I/CV and 22 healthy women were included in the assessment. The participants were administered WMS-R, the cancellation test, and the Stroop test as neuropsychological tests and p50 was assessed as a neurophysiological test. Results: The patient's results for the neuropsychological tests were found to be significantly low compared to the control group. The p50 sensory gating ratios of the patient group were statistically significantly lower than the controls. There was no significant correlation between the neuropsychological test scores and gating ratios of the patient and control groups. Conclusions: This study is the first to check sensory gating in conversion disorder patients with pseudoseizure and its most important result is finding reduced p50 sensory gating in patients. Our results suggest that these patients have a neurological tendency to this disease due to functional neurophysiological features. (C) 2013 Elsevier Inc. All rights reserved.
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    P50 sensory gating in patients with vaginismus
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Gul, Isil Gogcegoz; Karlidag, Rifat; Ozcan, A. Cemal
    Objective: P50 sensory gating was investigated in patients with primary vaginismus (PV) with the hypothesis that interpreting coping capacities as a stress factor during sexual intercourse by perceiving unrelated stimuli and an impairment of the sensory information processing may be associated with fear/anxiety related to a possible pain in vulvovagina. Methods: A total of 35 patients who were diagnosed with PV and 29 healthy volunteers matched for age and gender underwent P50 recording in the neurophysiology laboratory and the results were compared. Results: The PV group's P50 gating ratio and S1 amplitude were statistically significantly lower than in the control group. Conclusion: Sensory gating is required for filtering the stimuli coming to the brain and developing an appropriate behavioral response. The reduced formation of an appropriate behavioral response in the PV group can lead to a perception of excessive and unrelated stimuli coming from internal and external environments and interpreting these as a stress factor exceeding the capacity to cope. Our study is the first to evaluate sensory gating in PV patients and new studies with larger patient groups are required.
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    Pituitary volume in patients with panic disorder
    (Pergamon-Elsevier Science Ltd, 2011) Kartalci, Sukru; Dogan, Metin; Unal, Suheyla; Ozcan, A. Cemal; Ozdemir, Serdal; Atmaca, Murad
    Panic patients have many functional deficiencies in the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies have shown changed pituitary gland volume in some psychiatric disorders that have functional deficiencies in the HPA axis: However, to date no study has evaluated the pituitary gland volume in patients with panic disorder (PD). We investigated the pituitary gland volume in patients with PD (n = 27) and age- and sex-matched healthy controls (n = 27), using 1.5-T magnetic resonance imaging in this study. Analysis showed that patients with PD had significantly smaller pituitary volume compared to healthy subjects. Patients with agoraphobia especially had a significantly smaller pituitary volume than patients without agoraphobia. There was a significant relationship between the pituitary volume and both the severity of symptoms and the illness duration in the patient group. The results show that patients with PD have reduced pituitary volume, which may reflect the functional abnormalities seen in this disorder. These findings may help us better understand the pathology of PD. (C) 2010 Elsevier Inc. All rights reserved.
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    Vestibular evoked myogenic potentials at the womans with pseudoseizure
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2013) Han Almis, Behice; Elbozan Cumurcu, Birgul; Ozcan, A. Cemal; Unal, Suheyla
    Objective: We aimed to assess vulnerability in the lower brain stem at the patients with the pseudoseizure subtype of conversion disorder by vestibular evoked myogenic potentials (VEMP) in this study. Methods: In the study, 22 women with the diagnosis of conversion disorder which show convulsions according to SCID-I/CV and 22 healthy women are taken to assessment. After administration of SCID-I/CV by an experienced investigator to the patients and healthy controls, the sociodemographic data form, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were administered. VEMP evaluation performed at the patients and healthy control groups in a neurology laboratory. Results: P1 latency is no statistically significant difference at the patients with pseudoseizure compared to healthy control groups in the VEMP assessment at the right and left. Similarly, N1 latency values are no statistically significant difference between the patient and control groups. Right and left P1-N1 amplitude values no statistically significant difference at the patients with pseudoseizure compared to control groups values. Discussion: VEMP values no statistically significant difference at the patient compared to control groups at this study which it aimed to assess lower brain stem at the patients with the pseudoseizure subtype of conversion disorder by VEMP. This result is well adjusted hypothesis of increased corticofugal inhibition of afferent stimuli. However If P1-N1 (inhibition component) and N23-P44 (exitation component) components of VEMP waves to being careful, this subject will clear up. This study can plan again at the widely patients groups with deconvolution method and include other subtype of conversion disorder.