Yazar "Ozcan, C" seçeneğine göre listele
Listeleniyor 1 - 18 / 18
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Auditory event-related potentials in patients with premature ejaculation(Elsevier Science Inc, 2001) Ozcan, C; Ozbek, E; Soylu, A; Yilmaz, U; Guzelipek, M; Balbay, MDObjectives. To investigate in a descriptive manner the P300 component of the event-related potential (ERP), which is related to aspects of cognitive processing, in patients with premature ejaculation (PE) to determine whether there is a cognitive alteration in this condition. Recent studies with short latency evoked potentials such as cortical somatosensory evoked potentials have indicated that afferent sensory inputs from the genital area to the nervous system are increased in PE, However, the cortical neural process of ejaculation has remained poorly understood. Methods. We performed ERPs in 20 patients with PE and in 20 age-matched healthy subjects. ERPs were evoked by an auditory oddball paradigm consisting of 150 tone bursts (80% 1 kHz; 20% 2 kHz). The latencies of the N200 and the P300 waves and the amplitude of the P300 wave were measured. Results. The mean latencies of the N200 and P300 waves were significantly longer in the patients with PE than in the controls (P<0.04 and <0.03, respectively). No significant difference was found in the P300 amplitude between the controls and patients (P>0.05). Conclusions. These data indicate that the greater cortical representation of sensory stimuli from the genital areas that has been shown with somatosensory evoked potential studies might be related to a cognitive/neurobehavioral dysfunction. The dysfunction involves an increased time to evaluate and categorize the stimuli in the central nervous system, with no change in the quality of cognition and neural disinhibition by the prefrontal cortex to early sensory processing in subcortical or primary cortical regions, which are cognitive neural processes underlying ERP generation. UROLOGY 58: 1025-1029, 2001 (C) 2001, Elsevier Science Inc.Öğe Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels(Pergamon-Elsevier Science Ltd, 2006) Aladag, MA; Turkoz, Y; Ozcan, C; Sahna, E; Parlakpinar, H; Akpolat, N; Cigremis, YBackground: Cerebral vasospasm, a medical complication of aneurysmal subarachnoid hemorrhage (SAH), is associated with high morbidity and mortality rates, even after the aneurysm has been secured surgically or endovascularly. Evidence accumulated during the last decade suggest that scavenging a vasodilator, nitric oxide (NO), by superoxide anions (O-2(-)), and activating a strong vasoconstructor, protein kinase C (PKC), are the two most important mechanisms in the pathogenesis of vasospasm. Our aim in this study was to determine whether caffeic acid phenethyl ester (CAPE), a non-toxic oxygen free radical scavenger, prevents vasospasm in an experimental rat model of SAH. Methods: Twenty eight rats (225-250 g) were divided into four groups equally: group 1, control group group 2, SAH group; group 3, SAH plus placebo group; and group 4, SAH plus CAPE group. We used double haemorrhage method for SAH groups. Starting 6 h after SAH, 10 mu mol/kg CAPE or an equal volume of 0.9% saline were administered by intraperitoneal injection twice daily for 5 days to SAH plus CAPE and SAH plus placebo groups, respectively. CAPE or 0.9% saline injections were continued up to 5th day after SAH. Rats were sacrificed on the 5th day. Brain sections at the level of the pons were examined by light microscopy. Measurements were made for the cross-sectional areas of the lumen and the vessel wall (intimae plus media) of basilar artery by a micrometer. The levels of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) were measured in rat brain tissue. Results: Administration of CAPE significantly attenuated the vasoconstriction of the basilar artery. There were marked narrowing in the lumens of and thickening in the walls of basilar arteries in the SAH, and the SAH plus placebo compared with CAPE group (p < 0.001). We also observed that CAPE administration significantly decreased the tissue level of MDA, while significantly increased the tissue levels of GSH, NO in the SAH plus CAPE group compared to only SAH group, p < 0.05. Conclusions: Our results indicate that CAPE is effective in attenuating delayed cerebral vasoconstriction following experimental SAH. Our findings also suggest that the elevation of lipid peroxidation and reduction of NO bioavailability, resulting from the generation and the interaction of free radicals, have a significant role in the pathogenesis of vasospasm after SAH. (c) 2005 ISDN. Published by Elsevier Ltd. All rights reserved.Öğe Central pontine myelinolysis in Wilson's disease: MR spectroscopy findings(Elsevier Science Inc, 2004) Kizkin, S; Sarac, K; Ozisik, HI; Ozcan, CAlthough a pontine lesion on cranial MRI is frequently associated with an extrapontine lesion, few cases report solitary pontine involvement in Wilson disease, and it is usually recognized as central pontine lesions related to hepatic dysfunction. A patient with Wilson's disease having a solitary pontine lesion without basal ganglia involvement in cranial MRI with cerebellar symptoms is presented. Based on MR spectroscopy findings, this solitary pontine lesion could be regarded as central pontine myelinolysis rather than the neurologic involvement in Wilson's disease. (C) 2004 Elsevier Inc. All rights reserved.Öğe Cerebral artery hemodynamics in polycystic ovary syndrome(Taylor & Francis Ltd, 2005) Kizkin, S; Engin-Ustun, Y; Ustun, Y; Ozcan, C; Serbest, S; Ozisik, HIObjective. The aim of the present study was to investigate hemodynamic changes in the medial cerebral artery and also the internal carotid artery in young women with polycystic ovary syndrome (PCOS) and polycystic ovaries (PCO). Methods. Twenty-eight patients with PCOS, 16 patients with PCO and 24 healthy control subjects were included in the study. Blood flow rate, pulsatility index and back pressure of both the medial cerebral artery and the internal carotid artery were determined by transcranial Doppler ultrasonography and the results compared between groups. Results. There were no significant differences between the groups in bilateral medial cerebral artery and internal carotid artery blood flow rate, pulsatility index and back pressure. Conclusion. Our results do not indicate whether the risk of cerebrovascular events will increase for PCOS patients in middle and advanced age, but do show that changes in cerebral hemodynamics are not likely in PCOS at an early stage.Öğe Clitoral electromyography(Lippincott Williams & Wilkins, 2002) Yilmaz, U; Soylu, A; Ozcan, C; Caliskan, OPurpose: The clitoris has several histomorphological and functional similarities to the penis, In this study we evaluated spontaneous and evoked electromyography activity in the clitoris. Materials and Methods: We evaluated 11 healthy female volunteers with clitoral electromyography using a concentric needle electrode placed intracorporeally. The hand, foot and genital sympathetic skin responses, and spontaneous electrodermal activity were simultaneously recorded with silver surface electrodes. Another concentric needle electrode was placed subdermally on the mons pubis to differentiate clitoral activity from possible artifact. After recording spontaneous electromyography and electrodermal activity the left median nerve was stimulated to record evoked clitoral activity, and the sympathetic skin response in the hand, foot and genital regions. Results: There was spontaneous electromyography activity in the corpus clitoris. All dermal sites, including the hand, foot and genital regions, showed spontaneous electrodermal activity. No spontaneous activity was recorded from the subdermal needle electrode, Distraction of attention and coughing increased the amplitude and frequency of spontaneous clitoral electromyography and electrodermal activity at all sites. After stimulating the left median nerve all sites except that of the subdermal needle electrode showed evoked activity. Conclusions: The demonstrated evoked and spontaneous clitoral electromyography activity seems to indicate a sympathetic tonus of the corpus clitoris, as recorded from the corpus cavernosum of the penis in human males. Clitoral electromyography may be a useful objective assessment tool for evaluating female sexual dysfunction as well as genital autonomic innervation.Öğe Cognitive event-related potential and neuropsychological findings in Behcet's disease without neurological manifestations(Tohoku Univ Medical Press, 2005) Ozisik, HI; Karlidag, R; Hazneci, E; Kizkin, S; Ozcan, CBehcet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers and uveitis. BD patients without neurological involvement frequently have mild neurological symptoms. The aim of this study was to evaluate whether BD patients without neurological involvement have any changes in cognitive functions. Twenty BD patients without neurological involvement and 13 control subjects were included in the study and were analyzed by neurophysiological and neuropsychological examinations. The cognitive event- related potentials (P300) were recorded from the frontal, central and parietal areas of the right and left hemispheres of the patients and control subjects. Likewise, all individuals were evaluated with neuropsychological tests. In contrast to a study with similar design, C, we did not find any difference between the cognitive event-related potentials values of BD patients without neurological involvement and the control subjects. All BD patients without neurological involvement exhibit normal results of the neuropsychological test. In conclusion. the results of neuropsychological tests and cognitive event-related potentials values in BD patients without neurological involvement are indistinguishable from those in control subjects and no alteration of cognitive functions is present. (c) 2005 Tohoku University Medical Press.Öğe Crocodile tears syndrome: botulinum toxin treatment under EMG guidance(C I C-Edizioni Internazionali Srl, 2005) Kizkin, S; Doganay, S; Ozisik, HI; Ozcan, CIn conclusion, we recommend EMG guidance in the treatment of crocodile tears syndrome with botulinum toxin.Crocodile tears syndrome is one of the rare complications of facial paralysis. There have been several reports of cases in which botulinum toxin was found to be useful in the treatment of crocodile tears syndrome. The adverse effects, due to the paralytic action of botulinum toxin, have been reported to involve the palpebral muscle, lateral rectus and superior rectus. Therefore, we considered that it might be more appropriate to carry out the injection procedure under electromyographic guidance in order to inject botulinum toxin selectively into the lacrimal gland and protect the above-mentioned muscles.Öğe Decreased endothelium-dependent vasodilatation in patients with migraine: a new aspect to vascular pathophysiology of migraine(Lippincott Williams & Wilkins, 2006) Yetkin, E; Ozisik, H; Ozcan, C; Aksoy, Y; Turhan, HBackground Migraine is a common neurovascular disorder characterized by attacks of severe headache, autonomic and neurological symptoms. We hypothesized that patients with migraine had abnormal endothelial function. The vascular theory of migraine assumes that the major pathophysiological events that initiate the migraine attack occur in the perivascular nerves of the major cerebral vessels. Accordingly, we aimed to measure endothelium-dependent vasoclilatation in migraineurs by means of flow-mediated dilatation, which reflects endothelium-dependent vasodilatation capacity. Materials and methods Forty-five patients who fulfilled the diagnostic criteria for migraine and 45 age and sex-matched healthy participants were enrolled in the study. Flow-mediated dilatation of the brachial artery was determined using a high-resolution B-mode ultrasonographic system. Flow-mediated vasodilatation was expressed as the change in post-stimulus diameter as a percentage of the baseline diameter. Results Mean ages of the patients were 33 +/- 10 years in migraineurs (range: 18-52 years, 36 female, 9 male) and 33 +/- 9 years in non-migraineurs (range: 17-50 years, 36 female and 9 male). Flow-mediated dilatation of patients with migraine is significantly lower than that of the controls (8.02 +/- 4.095% vs. 10.72 +/- 3.52%, respectively, P=0.001). Conclusion We have shown that migraineurs have decreased endothelium-dependent vasodilatation capacity compared with non-migraineurs. Migraine may be a local manifestation of systemic vascular vasomotion abnormalities.Öğe The effects of different skill training on neuromuscular electric activity of the limbs in amateur sportsmen(Ios Press, 2005) Kaygusuz, A; Meric, F; Ertem, K; Duzova, H; Karakoc, Y; Ozcan, CIn this study, we investigated the effects of different skills of sport on electromyography (EMG) of limb muscles in sportsmen. Two different skill groups of sport consisted of 10 soccer players who use extensively lower limb, and 10 handball, basketball and volleyball players with selectively high usage of the upper limb. Surface EMG (sEMG) were recorded from the abductor pollicis brevis and gastrocnemius muscles of subjects. In addition, Hoffmann reflex (H-reflex) were recorded from the lower limb of participants. EMG findings of two groups were compared with each other and age-sex matched sedentary controls. Amplitude and area of sEMG recorded from gastrocnemius muscle of handball -basketball-volleyball players were significantly higher than those of soccer players (p < 0.01 and p < 0.05), whereas not significantly different based on the abductor pollicis brevis (p > 0.05 in both). F-response of both muscles and H-reflex of handball-basketball-volleyball players were also significantly higher from those of soccer players and control group (p < 0.05 for all), whereas only F-response of gastrocnemius muscle of soccer player was significantly lower than that of control group (p < 0.05). We conclude that EMG amplitude of gastrocnemius muscle, F-response and H-reflex times of lower limbs increase in handball-basketball-volleyball players due to the nature of training skills. Volleyball, handball or basketball training contributes to neuromuscular differences in both upper and lower extremities more than football training because both extremities are extensively used in these sport categories.Öğe Effects of Ranitidine on pulmonary function tests of patients with chronic obstructive pulmonary disease(Academic Press Ltd- Elsevier Science Ltd, 2003) Hasanoglu, HC; Yidirim, Z; Hasanoglu, A; Ozcan, C; Gokirmak, M; Koksal, N; Kalkan, SSince the incidence of peptic ulcer and gastroesophageal reflux (GER) is more common in patients with chronic obstructive pulmonary disease (COPD) than normal population, H-2 receptor blockers are given more extensively to COPD patients. This study evaluated the effects of Ranitidine on pulmonary function tests (PFT) of the patients having COPD and peptic ulcer or GER, and of healthy volunteers. Fifty milligrams of Ranitidine was given intravenously to 30 COPD patients and 25 healthy volunteers. PFT were done before and 15, 30, 60, 120 min after Ranitidine injection. Although mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and forced midexpiratory flow rate (FEF25-75%) Of COPD patients were found to be decreased 60 and 120 min after Ranitidine injection, the decrements were statistically insignificant. The decrements in PFT of healthy volunteers were also not statistically significant. H-2 receptor blockers can be used safely for treatment of gastrointestinal disorders in COPD patients who have mild or moderate obstruction. Minimal decreases in FEV1 and FVC due to treatment by H-2 receptor blockers may clinically worsen COPD patients who have severe obstruction. (C) 2003 Elsevier Science Ltd. All rights reserved.Öğe Evoked cavernous activity(Lippincott Williams & Wilkins, 2002) Yilmaz, U; Soylu, A; Ozcan, C; Kutlu, R; Gunes, APurpose: Corpus cavernosum electromyography has been widely done to evaluate autonomic dysfunction in patients with erectile dysfunction. We assessed the value of corpus cavernosum electromyography, evoked cavernous activity and penile sympathetic skin responses for their accuracy in determining autonomic involvement in cases of erectile dysfunction. Materials and Method: We evaluated 75 men with erectile dysfunction by corpus cavernosum electromyography, evoked cavernous activity and penile sympathetic skin response tests at our neurourology laboratory. The etiology of dysfunction was vascular, neurogenic, psychogenic or mixed based on a detailed medical and sexual history, physical examination, electrophysiological and laboratory studies, penile color Doppler ultrasonography, and cavernosography and/or cavernosometry. Autonomic involvement was clinically assessed by systemic findings, such as orthostatic hypotension, impaired gastrointestinal motility, sinus dysrhythmia and secretomotor changes. A concentric electromyography needle placed in the right cavernous body was used to record corpus cavernosum electromyography and evoked cavernous activity. The right median nerve was stimulated electrically with 13 to 16 mA. to determine evoked cavernous activity and the penile sympathetic skin response. The latter response was recorded with silver disc electrodes placed on the left cavernous body. All tests were performed using an electromyography/ evoked potential machine. We determined the relationships among corpus cavernosum electromyography, evoked cavernous activity and penile sympathetic skin response tests in respect to etiological factors. Results: The 56 patients with normal corpus cavernosum electromyography activity had also evoked cavernous activity and a penile sympathetic skin response except for 1 with no penile sympathetic skin response but evoked cavernous activity. None of these patients had autonomic neuropathy. Of the 19 patients without corpus cavernosum electromyography activity 11 had evoked cavernous activity, including 10 with no autonomic neuropathy. The remaining 8 patients had no evoked cavernous activity, of whom 7 had autonomic neuropathy. A penile sympathetic skin response was recorded in 18 men with absent corpus cavernosum electromyography. Conclusions: Due to false-negative results on corpus cavernosum electromyography and penile sympathetic skin response testing evoked cavernous activity seems more reliable for determining autonomic involvement in the pathophysiology of erectile dysfunction.Öğe Increased dilator response to nitrate in contrast to decreased flow mediated dilatation in migraineurs: An ultrasonographic evaluation of brachial artery(Elsevier Science Inc, 2006) Yetkin, E; Ozisik, H; Ozcan, C; Aksoy, Y; Turhan, H[Abstract Not Available]Öğe Intrinsic nasal muscles and their electromyographic evaluation after external septorhinoplasty(Mosby, Inc, 2001) Ozturan, O; Ozcan, C; Miman, MCOBJECTIVES: Rhinoplastic surgery is performed for the improvement in the appearance of the nose, but it should not cause any detrimental effect on the intrinsic muscles. This study was conducted to evaluate the influence of the external rhinoplasty on intrinsic nasal muscles. METHODS: Twenty-one patients were operated on by external septorhinoplasty. Functions of the nasal muscles were assessed by electromyography in response to voluntary nasal movements in patients before and after surgery. RESULTS: Postoperative electromyographic activities of the muscles were significantly less than preoperative measurements for all movements. CONCLUSION: Influence of the surgical incisions, alterations of the sites of origin and/or insertion of the muscles, and the postoperative healing process can be incriminated for the decreased muscular activity. Nasal muscle function requires a better appreciation and respect for the achievement of the best aesthetic and functional results. The nasal valve reconstructive procedures should be applied routinely to compensate for this inevitable muscular involvement.Öğe Late relapse in a patient with acute lymphoblastic leukemia thirteen years after diagnosis(Hemisphere Publ Corp, 1997) Aydogdu, I; Tayfun, E; Ozcan, C; Harputluoglu, M; Ozen, S; Hicsonmez, G[Abstract Not Available]Öğe Role of penile electrodermal activity in the evaluation of autonomic innervation of corpus cavernosum(Nature Publishing Group, 2004) Soylu, A; Yilmaz, U; Ozcan, C; Sarier, M; Baydinc, CElectrodiagnostic tests measuring the activities of cavernous smooth muscle and sudomotor structures of penile skin are used in order to evaluate autonomic innervation of the penis. Owing to closeness of these tissues, the interference of sympathetic activity during recording is a possibility. In this study, we investigated this possibility in 10 patients whose cavernosal tissues were destroyed during penile prosthesis implantation by comparing the pre- and postoperative penile skin electrodermal activities. Penile electrodermal activities were recorded with surface electrodes before and after the operation. All of the patients had spontaneous and evoked penile electrodermal activity (EDA). The mean amplitude of evoked EDA decreased from 2159 +/- 700 to 1413 +/- 515 muV following penile prosthesis surgery ( P = 0.017). The decrease in the amplitude of penile-evoked EDA following penile prosthesis implantation suggests the contribution of cavernous smooth muscle activity to the sudomotor responses prior to operation. Although corpus cavernosum sympathetic activity contributes to the penile skin recordings, these recordings are mostly the result of penile skin sudomotor sympathetic activity. Therefore, surface potentials recorded from penile skin should not be used for the evaluation of autonomic innervation of corpus cavernosum.Öğe Severe adverse skin reaction to chlorambucil in a patient with chronic lymphocytic leukemia(Rapid Science Publishers, 1997) Aydogdu, I; Ozcan, C; Harputluoglu, M; Karincaoglu, Y; Turhan, O; Ozcanu, A[Abstract Not Available]Öğe Sympathetic skin response in premenstrual syndrome(Springer Heidelberg, 2005) Ozisik, HI; Kamisli, O; Karlidag, R; Kizkin, S; Ozcan, CPremenstrual syndrome is a term which includes a broad group of emotional, behavioral and physical symptoms that occur for several days before menses and subside following the menstrual period. Many women experience premenstrual syndrome symptoms, particularly physical ones such as breast tenderness and swelling. Approximately 5-10% women suffer from severe premenstrual syndrome and another 30-40% have moderate symptoms. Premenstrual syndrome continues to be an unsolved problem. In this study, we evaluated 24 premenstrual syndrome patients and 20 healthy women in the control group. The ages of the women were 22-34 years (mean +/- SD: 25 +/- 3) for the premenstrual syndrome group and 23-34 (25 +/- 3) for the control group. The sympathetic skin response was recorded from the palms, soles and genital regions by using electrical stimuli to the median nerve at the wrist. The sympathetic skin response was recorded twice, in the follicular and late luteal phases of menstruation. The follicular and late luteal phase sympathetic skin response of the two groups were compared. The amplitudes and latency values of the late luteal and follicular phase sympathetic skin response from the premenstrual syndrome group and control group women were statistically similar. We also did not find any latency or amplitude difference in the sympathetic skin response obtained from the three regions of the premenstrual syndrome patients and the control group. We checked sympathetic skin response in the symptomatic (late luteal phase) and asymptomatic (follicular phase) periods of patients with premenstrual syndrome, a disorder known to have many autonomic symptoms, to determine whether there was sudomotor sympathetic involvement. The results of our PMS patients indicate at the very least that there is no difference with the control subjects as regards peripheral sudomotor functions.Öğe Topographic abnormalities in event-related potentials in children with monosyptomatic nocturnal enuresis(Wiley, 2004) Karlidag, R; Ozisik, HI; Soylu, A; Kizkin, S; Sipahi, B; Unal, S; Ozcan, CAims: A functional maturational delay in the central nervous system is dwelled upon in the pathogenesis of monosymptomatic nocturnal enuresis (NINE). In this study we studied whether according to controls N200 and P300, components of the event-related potential (ERP), which is related to aspects of cognitive processing, showed any difference in its topographic distribution in children within the age group 10-13 with monosymptomatic nocturnal enuresis and discussed its relation to the pathogenesis of MNE. Methods: We performed P300 in 18 patients with MNE and in 16 age-matched healthy subjects. P300 were evoked by an auditory oddball paradigm consisting of 150 tone bursts (80% 1 kHz; 20% 2 kHz). The latencies of the N200 and the P300 waves and the amplitude of the P300 wave were measured. Results: There was no statistical difference between the enuretic group and the controls in N200 and P300 latency and amplitude in the midline frontal (Fz), central (Cz), and parietal (Pz) recording site of the 10-20 International System. In the enuretic group while P300 amplitude in the Fz site was significantly less than the P300 amplitude in the Cz site, there was no statistical difference between the Fz and Pz P300 amplitude values. Conclusions: When different levels of maturational delay are considered in NINE, it may be claimed that maturational delay in children whose enuresis lasts until older ages will be different from those whose enuresis ends at an early age. The determination of P300 amplitude in parietal records being less in enuretics when compared to the controls may show that there are regional differences in stimuli processing rate/quality. (C) 2004 Wiley-Liss, Inc.
