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Öğe Analysis of vitamin d receptor polymorphisms in patients with familial multiple sclerosis(2018) Yucel, F.E.; Kamıslı, O.; Acar, C.; Sozen, M.; Tecellioğlu, M.; Ozcan, C.Objective: Genetic and environmental factors are important in the development of the multiple sclerosis (MS). Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. VDR gene polymorphism has not been previously studied in patients with familial MS. Aim: We aimed to investigate the relationship between familial MS patients present in Turkish population and VDR genotypes Taq I, Apa I and Fok I polymorphisms. Methods: 29 patients with a family history of MS and 120 healthy control subjects were included in the present study. We studied present VDR genotypes Taq I, Apa I and Fok I polymorphisms. Results: We observed a significant difference between controls and patient group only in Taq I polymorphism (p: 0.025). Homozygousity of G allele was not seen in the patients whereas in controls frequency of that genotype was p:0.208. When gender was considered males show significant difference for GG genotype. There were no significant association for the Apa I and Fok I polymorphisms. Conclusion: Although our findings suggest association between VDR Taq I polymorphism and the familial MS, additional studies are needed to establish detailed relationships.Öğe Bilateral episodic paroxysmal hemicrania: a case presentation(Springer Heidelberg, 2013) Kaplan, Y.; Kamisli, O.; Kamisli, S.; Altinayar, S.; Ozcan, C.[Abstract Not Available]Öğe Comparison of three conservative treatment protocols in carpal tunnel syndrome(Wiley, 2006) Baysal, O.; Altay, Z.; Ozcan, C.; Ertem, K.; Yologlu, S.; Kayhan, A.The aim of this study was to investigate and compare the therapeutic effect of three different combinations in the conservative treatment of carpal tunnel syndrome (CTS) by means of clinical and electrophysiological studies. The combinations included tendon- and nerve-gliding exercises in combination with splinting, ultrasound treatment in combination with splinting and the combination of ultrasound, splinting, tendon- and nerve-gliding exercises. A total 28 female patients (56 wrists) with clinical and electrophysiologic evidence of bilateral CTS were studied. In all patient groups, the treatment combinations were significantly effective immediately and 8 weeks after the treatment. The results of the long-term patient satisfaction questionnaire revealed that symptomatic improvement is more prominent in the group treated with splinting, exercise and ultrasound therapy combination. Our results suggest that a combination of splinting, exercise and ultrasound therapy is a preferable and an efficacious conservative type of treatment in CTS.Öğe Evaluation of aqueduct CSF flow dynamics with cine phase contrast MRI in patients with idiopathic intracranial hypertension(Wiley-Blackwell, 2014) Akay, R.; Kamisli, O.; Kahraman, A.; Oner, S.; Ozcan, C.[Abstract Not Available]Öğe Evaluation of polymorphisms of the angiotensinogen M235T and angiotensin-converting enzyme gene insertion/deletion in patients craniocervical arterial dissection(Wiley-Blackwell, 2014) Celik, H.; Kaplan, Y.; Yesilada, E.; Gulbay, G.; Kamisli, O.; Ozcan, C.; Altinayar, S.[Abstract Not Available]Öğe Gender differences in patients with craniocervical artery dissection(Wiley-Blackwell, 2015) Kablan, Y.; Kamisli, O.; Altinayar, S.; Ozcan, C.[Abstract Not Available]Öğe Gender differences in patients with total anterior circulation infarct(Wiley-Blackwell, 2012) Inanc, Y.; Kaplan, Y.; Kamisli, O.; Kamisli, S.; Ozcan, C.[Abstract Not Available]Öğe Hemoglobin A1c-related histologic characteristics of symptomatic carotid plaques(Wolters Kluwer Medknow Publications, 2019) Tecellioglu, M.; Alan, S.; Kamisli, S.; Tecellioglu, F. S.; Kamisli, O.; Ozcan, C.Background: The aims of our study were to compare the histomorphological characteristics of carotid plaques and glycosylated hemoglobin (HbA1c), which are risk factors for ischemic stroke, in patients who underwent carotid endarterectomy for carotid artery stenosis. Moreover, we aimed to identify the structures that were histologically affected by symptomatic carotid plaques in cases with elevated HbA1c. Materials and Methods: A total of 64 patients who presented with ischemic stroke and had not previously been diagnosed with diabetes were retrospectively evaluated. All stroke risk factors were reviewed. Carotid plaques were graded separately by two different pathologists through microscopic assessment of the following parameters: plaque rupture, lipid core, fibrous cup thickness, inflammation, intraplaque hemorrhage, thrombus, calcification, necrotic core, and neovascularization. An HbA1c value <6.3% was accepted as normal or indicative of prediabetes (group 1), whereas patients with values ranging between 6.3-7.4%, 7.5-8.4%, and 8.4% were categorized into the effectively controlled (group 2), less effectively controlled (group 3), and uncontrolled (group 4) groups, respectively. Results: The mean age of the patients was 73.0 4.5 years in group 1, 69.7 2.3 years in group 2, 66.0 8.5 years in group 3, and 62.7 7.1 years in group 4. A negative correlation was present between age and HbA1c. Smoking, hypertension, low-density lipoprotein cholesterol levels, and triglyceride levels were not significantly different among the four groups. According to the HbA1c classifications, the fibrous cup thickness was 2.64 0.3 mm in group 1, 1.85 0.4 mm in group 2, 1.68 0.5 mm in group 3, and 1.45 0.6 mm in group 4. The fibrous cup became thinner as the HbA1c value increased. Other parameters of unstable carotid plaques did not differ among the HbA1c groups. Conclusions: Increased HbA1c values seem to contribute to plaque instability through the formation of a thin fibrous cup. Thus, of the carotid artery plaque parameters including fibrous cup thickness, plaque rupture, lipid core, inflammation, intraplaque hemorrhage, thrombus, calcification, necrotic core, and neovascularization, fibrous cup thickness is the only histomorphological feature that affected by HbA1c.Öğe Increased mean platelet volume in cervicocephalic artery dissections(Springer London Ltd, 2012) Kamisli, O.; Kamisli, S.; Gonullu, S.; Kaplan, Y.; Ozcan, C.We aimed to investigate the role of platelets in the pathogenesis of cervicocephalic artery dissections by measuring the mean platelet volume (MPV) and platelet count. Thirty-four patients with evidence of cervicocephalic artery dissection were included in the study. Cervicocephalic artery dissection patients were divided into two subgroups as vertebral artery dissections and carotid artery dissections. There were 30 control subjects with similar baseline characteristics. The platelet count and MPV were compared between groups. The analysis showed a significant difference between the MPV values of the cervicocephalic artery dissection group and the control group (p < 0.05). However, when we compared subgroups with controls, we found a significantly higher MPV values only in the vertebral artery dissection group. We did not find any significant difference for total platelet count between the cervicocephalic artery dissection groups and controls. MPV is a marker of platelet function and activation. Increased MPV may be a result of dissection. In addition, it may be a risk factor for dissection-related stroke. Our study supports the notion that platelet reactivity is important in the pathogenesis of the cervicocephalic artery dissections, especially in vertebral artery dissections.Öğe Neuroprotective effects of hesperidin in a C57BL/6 mouse model of multiple sclerosis(Sage Publications Ltd, 2014) Ciftci, O.; Ozcan, C.; Kamisli, O.; Cetin, A.; Basak, N.; Aytac, B.[Abstract Not Available]Öğe P50 sensory gating in hypoxemic chronic obstructive pulmonary disease patients(Verduci Publisher, 2013) Kamisli, O.; Ermis, H.; Kamisli, S.; Gulbas, G.; Kablan, Y.; Ozcan, C.PURPOSE: Chronic obstructive pulmonary disease (COPD) is a condition characterized by progressive airway obstruction and recurrent attacks. Multisystem involvement with extra-pulmonary manifestations has been seen in COPD patients. Numerous neurological involvement like cerebrovascular diseases, polyneuropathies, motor neuron diseases and cognitive impairement has been reported in COPD patients. Cognitive dysfunction is usually associated with hypoxia or hypercapnia in COPD patients. To our knowledge there is no study about sensory gating in COPD patients. We performed p50 test to COPD patients and we investigate sensory gating in COPD patients. PATIENTS AND METHODS: 25 male patients with COPD and 17 healthy male subjects for controls included to this study. The patients were diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. p50 amplitude and latency, percentage of P50 suppression, N100 amplitude and latency and the N100 suppression percentage of the COPD patients and controls presented were measured and compared. RESULTS: We found that the conditioning amplitudes (S1) did not differ between COPD patients and controls (p > 0.05) but (S2) amplitude was significantly increased in COPD patients (p < 0.05). COPD patients showed significantly lower P50 and N100 suppression percentage than controls (p < 0.05). CONCLUSIONS: COPD patients showed a disturbance cognitive function such as attention with p50 suppression rate decrease. P50 sensory gating test can be useful to analyze the pre-attention period of cognitive impairment in the early phase of COPD patients.Öğe Peduncular hallucinosis related with multiple sclerosis: a case report(Springer Heidelberg, 2012) Kamisli, O.; Kaplan, Y.; Kamisli, S.; Ozcan, C.[Abstract Not Available]Öğe Relationships of total leukocyte, neutrophil and lymphocyte levels with the menstrual cycle in patients receiving fingolimod treatment(Verduci Publisher, 2021) Ekmekyapar, T.; Ozcan, C.; Ciftci, O.OBJECTIVE: Multiple sclerosis (MS) is a demyelinating, chronic, and progressive autoimmune disease of the central nervous system that causes the loss of axons and grey matter, and has a high prevalence in young female patients. Fingolimod is an oral treatment agent that acts by blocking the passage of the T lymphocytes responsible for the pathogenesis of MS from lymphoid tissue into the peripheral blood. We aimed to research the effects of menstrual cycles on leukocytes and lymphocyte levels in RRMS (relapsing-remitting MS) patients who received fingolimod treatment. PATIENTS AND METHODS: This study was performed to determine the most suitable phase of the menstrual cycle in patients with RRMS for follow-up assessment of lymphopaenia levels after fingolimod treatment. The study population consisted of 41 RRMS patients receiving fingolimod therapy and 33 healthy women of reproductive age. Complete blood counts were performed in three different phases of the menstrual cycle, and the two groups were compared. Variability in the total leukocyte, lymphocyte, and neutrophil immune cell numbers between cycles was examined. RESULTS: The results indicated that total leukocyte, neutrophil. and lymphocyte levels were decreased in RRMS patients receiving fingolimod treatment, but these changes were not related to the phase of the menstrual cycle. In our study, leukocyte levels in healthy individuals were significantly lower in the proliferative phase than in other phases. CONCLUSIONS: The results indicated that lymphocyte monitoring in RRMS patients receiving fingolimod treatment can be performed at any stage of the menstrual cycle.Öğe Resveratrol prevents the experimental autoimmune encephalomyelitis (EAE) in C57BL/J6 mouse model(Sage Publications Ltd, 2016) Ciftci, O.; Ozcan, C.; Cetin, A.; Basak, N.; Kamisli, O.[Abstract Not Available]Öğe Serum Gamma-glutamyltransferase Levels in Ischemic Stroke Subtypes(Karger, 2013) Kamisli, O.; Gonullu, S.; Kaplan, Y.; Kamisli, S.; Altinayar, S.; Ozcan, C.[Abstract Not Available]
