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    Ancient schwannoma in phthisis bulbi: Case ReporT
    (2019) Ozcan, Mehmet; Akatli, Ayse Nur; Turkmen Samdanci, Emine; Demirel, Soner
    Abstract: Schwannoma is benign nerve sheath tumor of Schwann cells. A 41-year-old female patient presented with pain and a complaint of inability to see. A mass revealed in left eye. Mass was histopathologically evaluated as schwannoma. This lesion in a rare location is presented with the literature
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    Histopathological features of incidental appendectomy specimens obtained from living liver donors
    (Aves, 2020) Akbulut, Sami; Koc, Cemalettin; Sarici, Baris; Ozcan, Mehmet; Samdanci, Emine; Yilmaz, Sezai
    Background/Aims: To determine the histopathological features of incidental appendectomy specimens obtained from living liver donors (LLDs) Materials and Methods: Between September 2005 and November 2018, 1910 LLDs underwent living donor hepatectomy at our institute. Incidental appendectomy together with living donor hepatectomy (LDH) was performed in 170 LLDs. The decision for incidental appendectomy was made by experienced gastrointestinal surgeons. Histopathological features of the appendectomy specimens were analyzed by two pathologists, and the following parameters were retrospectively evaluated: age, sex, appendix length (mm), appendix width (mm), presence of appendicitis, and unusual histopathological findings. Results: Histopathological findings from 97 male and 73 female LLDs aged between 18 and 64 (median: 30) years were retrospectively examined. The length of the appendix vermiformis ranged from 25 to 120 (median: 70) mm, whereas its width ranged from 4 to 13 (median: 6) mm. The following histopathological findings were observed: normal appendix vermiformis (n=137), fibrous obliteration (n=13), acute appendicitis (n=5), enterobius vermicularis (n=4), lymphoid hyperplasia (n=4), low-grade appendiceal mucinous neoplasm (n=2), mucinous cystadenoma (n=1), grade 1 neuroendocrine tumor (n=1), hyperplastic polyp (n=1), enterobius vermicularis with fibrous obliteration (n=1), and acute appendicitis with eosinophilic infiltration (n=1). Conclusion: This study showed that a careful inspection of the abdominal cavity was useful, and appendectomy should be performed when required. In addition, even if the macroscopic appearance of the appendectomy specimens is normal, histopathological evaluations facilitate an early diagnosis of numerous unusual appendiceal diseases.
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    A rare reason of PSA elevation seen during intravesical BCG therapy: Granulomatous prostatitis
    (2019) Cimen, Serhan; Gunes, Ali; Oguz, Fatih; Topcu, Ibrahim; Akatli, Ayşe Nur; Ozcan, Mehmet
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    Xanthogranulomatous appendicitis: A comprehensive literature review
    (Baishideng Publishing Group Inc, 2021) Akbulut, Sami; Demyati, Khaled; Koc, Cemalettin; Tuncer, Adem; Sahin, Emrah; Ozcan, Mehmet; Samdanci, Emine
    BACKGROUND Xanthogranulomatous inflammation is characterized histologically by a collection of lipid-laden macrophages admixed with lymphocytes, plasma cells, neutrophils, and often multinucleated giant cells with or without cholesterol clefts. AIM To review the medical literature on xanthogranulomatous appendicitis (XGA). METHODS We present a patient with XGA and review published articles on XGA accessed via the PubMed, MEDLINE, Google Scholar, and Google databases. Keywords used were appendix vermiformis, appendectomy, acute appendicitis, and XGA. The search included articles published before May 2020, and the publication language was not restricted. The search included letters to the editor, case reports, review articles, original articles, and meeting presentations. Articles or abstracts containing adequate information about age, sex, clinical presentation, white blood cells, initial diagnosis, surgical approach, histopathological and immunohistochemical features of appendectomy specimens were included in the study. RESULTS A total of 29 articles involving 38 patients with XGA, were retrospectively analyzed. Twenty (52.6%) of the 38 patients, aged 3 to 78 years (median: 34; IQR: 31) were female, and the remaining 18 (47.4%) were male. Twenty-five patients were diagnosed with acute appendicitis, ruptured appendicitis, or subacute appendicitis, and the remaining 13 patients underwent surgery for tumoral lesions of the ileocecal region. Twenty-two of the patients underwent urgent or semi-urgent surgery, and the remaining 16 patients underwent interval appendectomy. CONCLUSION Xanthogranulomatous inflammation rarely affects the appendix vermiformis. It is associated with significant diagnostic and therapeutic dilemmas due to its variable presentation. It is often associated with interval appendectomies, and a significant number of patients require bowel resection due to the common presentation of a tumoral lesion. XGA is usually identified retrospectively on surgical pathology and has no unique features in preoperative diagnostic studies.