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    Analysis of Vitamin D Receptor Polymorphisms in Patients with Familial Multiple Sclerosis
    (2018) Yucel F.E.; Kamıslı O.; Acar C.; Sozen M.; Tecellioğlu M.; Ozcan C.
    Objective: Genetic and environmental factors are important in the development of the multiple sclerosis (MS). Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. VDR gene polymorphism has not been previously studied in patients with familial MS.Aim: We aimed to investigate the relationship between familial MS patients present in Turkish population and VDR genotypes Taq I, Apa I and Fok I polymorphisms.Methods: 29 patients with a family history of MS and 120 healthy control subjects were included in the present study. We studied present VDR genotypes Taq I, Apa I and Fok I polymorphisms.Results: We observed a significant difference between controls and patient group only in Taq I polymorphism (p: 0.025). Homozygousity of G allele was not seen in the patients whereas in controls frequency of that genotype was p:0.208. When gender was considered males show significant difference for GG genotype. There were no significant association for the Apa I and Fok I polymorphisms.Conclusion: Although our findings suggest association between VDR Taq I polymorphism and the familial MS, additional studies are needed to establish detailed relationships.
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    Insidious homonymous quadrantic visual field defect revealed after a sudden bilateral loss of vision: Report of two cases
    (2001) Evereklioglu C.; Ozcan C.; Doganay S.; Er H.
    Objective: To report two patients with sudden transient complete loss of vision in their both eyes because of cortical blindness and to emphasize the importance of close monitoring with computerized tomography (CT), magnetic resonance imaging (MRI) and perimetry. Materials and Methods: Complete ophthalmologic and neurological examinations were performed in two patients with sudden bilateral loss of vision. Perimetry, CT and MRI were carried out in both patients and the clinical significance was discussed. Results: After recovery from complete visual loss, one patient (40-years old woman) showed congruous right-side superior homonymous quadrantanopsia because of the pre-existed infarction in the left side. The quadrantanopia was accompanied by increased T2-weighted contrast intensity of bilateral regions in the occipital cortex. The second patient (28-years old woman) showed right-side superior homonymous quadrantanopia because of the subacute infarction with increased T2-weighted contrast intensity of the left parahypocampal area reaching parietoccipital sulcus. Not the sudden transient visual loss lasting 2 hours as a consequent of cortical blindness, but interestingly quadrantic right superior visual field defects were the main complaints of the patients on admission. Conclusion: Both cases are of interest because of unrecognized pre-existed quadrantanopia was present and unilateral aforementioned lesions were noticed by physicians only after sudden complete but transient bilateral loss of visions (cortical blindness). We suggest that all patients complaining transient bilateral sudden visual loss should be evaluated more carefully and have perimetry even neurological examination reveals normal results.
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    Letter to the Editor [1]
    (Blackwell Publishing Ltd, 1996) Bayramlar H.; Hepsen I.F.; Ozcan C.; Boluk A.; Er H.; Evereklioglu C.
    [No abstract available]
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    A Rare Presentation of Cranial Polyneuropathy Without Rash Caused by Varicella Zoster Virus
    (2017) Tecellioglu M.; Kamisli S.; Erbay M.F.; Kamisli O.; Ozcan C.
    INTRODUCTION: Varicella Zoster Virus (VZV) is associated with many disorders of the central and peripheral nervous systems including neuralgia, meningitis, meningoencephalitis, cerebellitis, vasculopathy, myelopathy, Ramsay-Hunt syndrome, and polyneuritis cranialis. Cranial nerves V, VI, VII, VIII, IX, X, XI, and/or XII may be affected. The neurological disorders caused by VZV usually present with rash, but may rarely present without rash.CASE REPORT: We herein present a case of polyneuritis cranialis without rash caused by VZV affecting cranial nerves VII, VIII, IX, and X. After excluding other causes of the condition, we diagnosed VZV infection based on VZV DNA in the CSF and an elevated anti-VZV IgG level in serum. The patient responded well to antiviral therapy.CONCLUSION: VZV infection should be kept in mind during the differential diagnosis of polyneuritis cranialis; it is important to note that VZV re-activation may occur without rash.