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    Anti-inflammatory Effects and Pharmacokinetics of Bupivacaine in Transversus Abdominis Plane Block for Living Liver Donors: A Prospective Randomized Clinical Trial
    (Elsevier Science Inc, 2025) Yalin, Mehmet Ridvan; Erdogan, Mehmet Ali; Ucar, Muharrem; Uremis, Muhammed Mehdi; Colak, Yusuf Ziya; Ozdemir, Emine; Ugur, Yilmaz
    Objective. Transversus abdominis plane (TAP) blocks have been reported to decrease postoperative pain and opioid use. Local anesthetics modulate the local and systemic inflammatory reaction. Our aim was to examine the effect of TAP block with bupivacaine on the antiinflammatory response in living liver donors. Methods. The randomized prospective clinical study was carried out on 72 living liver donors, aged 18 to 65 scheduled for right hepatectomy. TAP blocks were performed bilaterally with ultrasound guidance using 1.5 mg/kg of 0.5% bupivacaine for group 2. Group 1 patients were the control group. In both groups, blood samples were obtained preoperatively, 30 minutes and 2, 6, and 24 hours after the injection for cytokine measurement. In group 2, to examine the plasma bupivacaine level, blood samples were obtained preoperatively as well as 30 minutes and 1, 2, 6, 12, and 24 hours after injection. The primary outcome was to assess the effect of TAP block on the inflammatory response using cytokine levels. Results. No difference was observed between cytokine levels (tumor necrosis factor-alpha, interleukin [IL]-1 and IL-6) between groups Significant positive correlations were observed between the plasma bupivacaine concentration and IL-1 and IL-6 levels at 2, 6, and 24 hours. Conclusion. Although the TAP block did not affect the levels of cytokines significantly, a significant association was seen between the concentrations of plasma bupivacaine and the levels of IL-1 and IL-6 at 2, 6, and 24 hours. In contrast, the clinical significance of this association is still under investigation.
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    Oropharyngeal continuous positive airway pressure: An alternative to intubation for newborns not applied nasal continuous positive airway pressure
    (Wolters Kluwer Medknow Publications, 2016) Demirtas, Mehmet Semih; Turgut, Hatice; Ozdemir, Emine; Karadag, Ahmet
    [Abstract Not Available]
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    Successful difficult airway management of a child with Coffin-siris syndrome
    (Wiley, 2017) Ozkan, Ahmet Selim; Akbas, Sedat; Yalin, Mehmet Ridvan; Ozdemir, Emine; Koylu, Zeynep
    Key Clinical Message Management of airway in patients who have Coffin-Siris syndrome (CSS) is often problematic because most of these patients have difficult airway. NTI via C-MAC VL is an useful alternative to direct laryngoscope for orotracheal intubation in airway and anesthetic management in a case of CSS. Alternative airway devices should be readily available.
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    The effects of erector spinae plane block on pain scores and patient experience in unilateral breast cancer surgery: A prospective, randomized clinical trial
    (2025) Ucar, Muharrem; Sanli, Mukadder; Ozkan, Ahmet Selim; Özdeş, Oya Olcay; Ozdemir, Emine; Şanlı, Bayram
    Aim: Breast cancer incidence continues to rise, leading to increased demand for surgical interventions. Postoperative analgesia following breast operations remains an area requiring optimization. The erector spinae plane block (ESP) represents a newer regional technique that may provide advantages over alternative methods. In breast cancer surgeries, We investigated whether unilateral ESP blockade before surgery affected opioid consumption during surgery and improved postoperative pain management and patient satisfaction. Materials and Methods: The study was prospectively randomized and controlled. One hundred women scheduled for unilateral breast cancer surgery were enrolled in the study and randomly assigned to either the ESP block group (Group I, n=50) or the standard care group without block (Group II, n=50). The primary outcome was perioperative opioid consumption. Secondary outcomes included postoperative narcotic consumption, Visual Analog Scale (VAS) pain ratings, urgent analgesic requirements, and patient satisfaction. Results: Intraoperative opioid consumption was lower in Group I; postoperative pain scores, opioid consumption, and patient satisfaction scores were better compared to Group II.Conclusion: ESP block, a recently developed regional analgesia approach, improved postoperative pain outcomes and enhanced patient satisfaction following breast cancer surgery.