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Öğe Anti-tumor properties of microwave-assisted synthesized 6,7-dihydroxycoumarins: An in vitro study(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Determination of antitumor properties of cyclophosphazene derivatives bearing chalcone-groups against PC-3 cell lines(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Determination of Cytotoxicity Properties of Newly Synthesized Chalcone-Cyclophosphazene Compounds against Human Prostate Cancer Cell Lines(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Investigation of Anti-Carcinogenic Properties of 2-(2,3,4-trimethoxyphenyl)-1-(substituephenyl) Acrylonitrile and 7,8-dihydroxy-1-(substituephenyl) Coumarine Compounds against Human Breast Cancer Cell Lines(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Synthesis of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell lines(Springer, 2016) Ozen, Furkan; Tekin, Suat; Koran, Kenan; Sandal, Suleyman; Gorgulu, Ahmet OrhanA series of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitrile (2-9) were designed and synthesized to develop new cancer drugs. The structures of synthesized compounds 2-9 were described by using melting point, mass (MALDI-TOF-MS), FT-IR, elemental analysis, H-1, C-13, C-13-APT and 2D NMR spectroscopy. The in vitro anticancer activities of 2-9 against human breast cancer (MCF-7), human prostate cancer (PC-3) and human ovarian cancer cells (A2780) were investigated by [3-(4,5-dimethylthiazol)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide] (MTT) assay method. Additionally, the LogIC(50) values of these compounds on A2780, MCF-7 and PC-3 cell lines were calculated by using inhibition % values by the GraphPad Prism 6 program on a computer. The results indicated that these compounds have high anticancer activity against MCF-7, PC-3 and A2780 cell lines (especially A2780 cell lines, p < 0.05).Öğe Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups(Elsevier Science Bv, 2015) Gorgulu, Ahmet Orhan; Koran, Kenan; Ozen, Furkan; Tekin, Suat; Sandal, Suleyman2,2-Dichloro-4,4,6,6-bis[spiro(2',2 ''-dioxy-1',1 ''-biphenylyl]cyclotriphosphazene (2) was synthesized from hexachlorocyclotriphosphazene (HCCP) and 2,2'-dihydroxybiphenyl. The mixed substituent chalcone/dioxybiphenyl cyclophosphazenes (2a-h) were obtained from the reactions of (2) with hydroxy chalcone compounds in K2CO3/acetone system. The chalcone-cyclophosphazene compounds were characterized by elemental analysis, FT-IR, H-1, C-13, P-31 NMR techniques. In vitro anti-carcinogenic activities of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MU) assay. Anti-carcinogenic activity of the compounds (2a-h) against androgen-dependent (LNCaP) and independent (PC-3) human prostate cancer cell lines were investigated. Our results indicate that the chalcone-phosphazene compounds (2a-h) have anti-carcinogenic activity on PC-3 and LNCaP cell lines (p < 0.05). The effective dose of the compounds was determined as 100 mu M. (C) 2015 Elsevier B.V. All rights reserved.Öğe Synthesis, structural characterization, and in vitro anti-cancer activities of new phenylacrylonitrile derivatives(Korean Soc Applied Biological Chemistry, 2016) Ozen, Furkan; Tekin, Suat; Koran, Kenan; Sandal, Suleyman; Gorgulu, Ahmet OrhanThe present study was designed to both synthesize phenylacrylonitrile compounds (1a-k) and their anti-tumor activities on human breast cancer cell line (MCF-7) were determined. The structures of all the compounds were defined by melting point, elemental analysis, FT-IR, H-1, C-13, C-13-APT, and HETCOR-NMR spectroscopy. Anti-tumor activities of these compounds on cell viability were evaluated using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay against MCF-7. The MCF-7 cell lines were treated with 1, 5, 25, 50, and 100 mu M concentrations of phenylacrylonitrile compounds for 24 h. At the end of the experiments, 1a, 1b, 1c, 1g, and 1h compounds reduced cell viability (p < 0.01). Additionally, the anti-cancer activities of these compounds on MCF-7 were investigated by comparing IC50 values. In conclusion, while some of the synthesized phenylacrylonitrile compounds (1a, 1b, 1c, 1g, and 1h) have antitumor activity, other phenylacrylonitrile compounds (1d, 1e, 1f, 1k, and 1h) have no effect on human breast cell lines.
